Recombinant human bone morphogenetic protein-type 2 (rhBMP-2) enhances local bone formation in the lumbar spine of osteoporotic sheep

ABSTRACT The failure of orthopedic implants in osteoporotic patients is attributed to the lack of sufficient bone stock and regenerative capacity but most treatments for osteoporosis fail to address this issue. rhBMP‐2 is known to promote bone formation under normal conditions but has not been used...

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Veröffentlicht in:	Journal of orthopaedic research 2013-09, Vol.31 (9), p.1390-1397
Hauptverfasser:	Zarrinkalam, Mohammad Reza, Schultz, Christopher G, Ardern, David W, Vernon-Roberts, Barrie, Moore, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptiometry, Photon Animals Bone Density - drug effects Bone Morphogenetic Protein 2 - pharmacology Calcium - deficiency Calcium, Dietary - administration & dosage Delayed-Action Preparations - administration & dosage Disease Models, Animal Female Glucocorticoids - pharmacology Humans lumbar spine Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - drug effects Lumbar Vertebrae - pathology Osteogenesis - drug effects Osteoporosis - drug therapy Osteoporosis - etiology Osteoporosis - pathology osteoporotic sheep Ovariectomy Recombinant Proteins - pharmacology rhBMP-2 Sheep - physiology Tomography, X-Ray Computed trabecular bone Transforming Growth Factor beta - pharmacology
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