Regulation of the cardiac Na+ /H+ exchanger in health and disease

Abstract The Na+ gradient produced across the cardiac sarcolemma by the ATP-dependent Na+ -pump is a constant source of energy for Na+ -dependent transporters. The plasma membrane Na+ /H+ exchanger (NHE) is one such secondary active transporter, regulating intracellular pH, Na+ concentration, and ce...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2013-08, Vol.61, p.68-76
Hauptverfasser:	Wakabayashi, Shigeo, Hisamitsu, Takashi, Nakamura, Tomoe Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Calcineurin Calcineurin - metabolism Calcineurin B homologous protein Calmodulin Calmodulin - metabolism Cardiac hypertrophy Cardiomegaly - metabolism Cardiovascular Cation Transport Proteins - chemistry Cation Transport Proteins - metabolism Heart Failure - metabolism Hormonal regulation Humans Lipid Metabolism Na+/H+ exchanger Protein Structure, Secondary Protein Structure, Tertiary Signal Transduction Sodium-Hydrogen Exchanger 1 Sodium-Hydrogen Exchangers - chemistry Sodium-Hydrogen Exchangers - metabolism
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