Overexpressed nuclear BAG-1 in human hepatocellular carcinoma is associated with poor prognosis and resistance to doxorubicin

Bcl‐2‐associated athanogene‐1 (BAG‐1) is a multifunctional anti‐apoptotic protein which regulates an array of cellular processes, including apoptosis, signaling, proliferation, transcription, and cell motility and has been reported to be over‐expressed in a number of human malignancies. To investiga...

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Veröffentlicht in:	Journal of cellular biochemistry 2013-09, Vol.114 (9), p.2120-2130
Hauptverfasser:	Ni, Wenkai, Chen, Buyou, Zhou, Guoxiong, Lu, Cuihua, Xiao, Mingbing, Guan, Chengqi, Zhang, Yixing, He, Song, Shen, Aiguo, Ni, Runzhou
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects BCL-2-ASSOCIATED ATHANOGENE-1 (BAG-1) Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Cell Cycle - drug effects Cell Cycle - genetics CHEMORESISTANCE DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Doxorubicin - pharmacology Doxorubicin - therapeutic use Drug Resistance, Neoplasm - genetics Female Hep G2 Cells HEPATOCELLULAR CARCINOMA (HCC) Humans Immunohistochemistry In Vitro Techniques Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Male Middle Aged NUCLEAR FACTOR-κB (NF-κB) PROGNOSIS RNA, Small Interfering - genetics Transcription Factors - genetics Transcription Factors - metabolism Young Adult
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