Value of D-dimer and C reactive protein in predicting inhospital death in acute aortic dissection
Objective To evaluate the role of D-dimer and C reactive protein (CRP) in predicting inhospital death in acute aortic dissection (AD). Design A single-centre prospective study. Setting University hospital in China. Patients 114 patients with acute AD. Intervention Admission D-dimer and CRP concentra...
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| Veröffentlicht in: | Heart (British Cardiac Society) 2013-08, Vol.99 (16), p.1192-1197 |
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| creator | Wen, Dan Du, Xin Dong, Jian-Zeng Zhou, Xian-Liang Ma, Chang-Sheng |
| description | Objective To evaluate the role of D-dimer and C reactive protein (CRP) in predicting inhospital death in acute aortic dissection (AD). Design A single-centre prospective study. Setting University hospital in China. Patients 114 patients with acute AD. Intervention Admission D-dimer and CRP concentrations were assayed. Main outcome measures To observe the association of D-dimer and CRP with inhospital death. Results Increased levels of plasma D-dimer (9.84±3.53 vs 4.28±1.99, P |
| doi_str_mv | 10.1136/heartjnl-2013-304158 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1411627857</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4021080071</sourcerecordid><originalsourceid>FETCH-LOGICAL-b479t-ded49609d243c2ebbbfd1eb12d3040dcd23454634c03689d4eb2117217033f113</originalsourceid><addsrcrecordid>eNqNkU1v1DAQhi0Eoh_wDxCyxIVLqMd2bOeItrQgFTgUqt4sJ56wXvKxtR0E_x6v0vbACcmSPTPPjF7PS8grYO8AhDrboot5Nw0VZyAqwSTU5gk5BqnMIXX7tLxFXVeKCX1ETlLaMcZkY9RzcsSFAWFqdkzcjRsWpHNPzysfRozUTZ5uaETX5fAL6T7OGcNEy9lH9KFkpx8l2s5pH7IbqEeXt4ey65aM1M0xh476kBIWdp5ekGe9GxK-vL9PyfeLD982H6urr5efNu-vqlbqJlcevWwUazyXouPYtm3vAVvgvnyN-c5zIWuphOyYUKbxElsOoDloJkRfNnJK3q5zi-K7BVO2Y0gdDoObcF6SBQmguDa1Luibf9DdvMSpqLOgDdNcq1oUSq5UF-eUIvZ2H8Po4h8LzB4ssA8W2IMFdrWgtL2-H760I_rHpoedF6BagZAy_n6su_jTKi10bb_cbCx8vlDX57fGXhf-bOXbcfd_Ev4CJ0ihbw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1780727653</pqid></control><display><type>article</type><title>Value of D-dimer and C reactive protein in predicting inhospital death in acute aortic dissection</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Wen, Dan ; Du, Xin ; Dong, Jian-Zeng ; Zhou, Xian-Liang ; Ma, Chang-Sheng</creator><creatorcontrib>Wen, Dan ; Du, Xin ; Dong, Jian-Zeng ; Zhou, Xian-Liang ; Ma, Chang-Sheng</creatorcontrib><description>Objective To evaluate the role of D-dimer and C reactive protein (CRP) in predicting inhospital death in acute aortic dissection (AD). Design A single-centre prospective study. Setting University hospital in China. Patients 114 patients with acute AD. Intervention Admission D-dimer and CRP concentrations were assayed. Main outcome measures To observe the association of D-dimer and CRP with inhospital death. Results Increased levels of plasma D-dimer (9.84±3.53 vs 4.28±1.99, P < 0.001), CRP (14.08±2.81 vs 11.18±1.85, P < 0.001) and aortic diameter (45.2±9.5 vs 40.3±6.0, p = 0.007) were found in dead patients compared with those survived. Moreover, plasma D-dimer concentrations in type A were higher than that in type B (6.51±4.11 vs 4.87±2.29, p = 0.013). Plasma D-dimer concentrations had positive correlations with CRP levels (r=0.527, P < 0.001) and aortic diameter (r=0.227, p = 0.015), and had negative correlations with the type of AD (r=−0.232, p = 0.013) and the time from onset (r=−0.264, p = 0.005). D-dimer and CRP levels and the type of AD were strongly associated with inhospital mortality. The OR and 95% CI were 3.272, 1.638 to 6.535; 2.322, 1.134 to 4.757; and 0.126, 0.019 to 0.853, respectively. Furthermore, the sensitivity and specificity of D-dimer ≥5.67 μg/mL in predicting inhospital death in acute AD were 90.3% and 75.9% (95% CI 0.85 to 0.96), respectively. Moreover, the sensitivity and specificity of CRP levels ≥11.21 mg/L were 100% and 54.2%, respectively (95% CI 0.74 to 0.89). Conclusions D-dimer ≥5.67 μg/mL, CRP ≥11.21 mg/L and type A acute AD were important risk factors and independently associated with acute AD inhospital death.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/heartjnl-2013-304158</identifier><identifier>PMID: 23813850</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Acute Disease ; Adult ; Aneurysm, Dissecting - blood ; Aneurysm, Dissecting - diagnosis ; Aneurysm, Dissecting - mortality ; Aortic Aneurysm - blood ; Aortic Aneurysm - diagnosis ; Aortic Aneurysm - mortality ; Biomarkers - blood ; C-Reactive Protein - analysis ; Cardiovascular disease ; Chi-Square Distribution ; China ; Cholesterol ; Diabetes ; Dissection ; Female ; Fibrin Fibrinogen Degradation Products - analysis ; Hospital Mortality ; Hospitalization ; Hospitals, University ; Humans ; Hypertension ; Logistic Models ; Low density lipoprotein ; Male ; Marfan syndrome ; Medical prognosis ; Middle Aged ; Mortality ; Multivariate Analysis ; Odds Ratio ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Proteins ; Risk Assessment ; Risk Factors ; Surgery ; Up-Regulation ; Variables</subject><ispartof>Heart (British Cardiac Society), 2013-08, Vol.99 (16), p.1192-1197</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2013 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b479t-ded49609d243c2ebbbfd1eb12d3040dcd23454634c03689d4eb2117217033f113</citedby><cites>FETCH-LOGICAL-b479t-ded49609d243c2ebbbfd1eb12d3040dcd23454634c03689d4eb2117217033f113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://heart.bmj.com/content/99/16/1192.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://heart.bmj.com/content/99/16/1192.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3183,23550,27901,27902,77342,77373</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23813850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wen, Dan</creatorcontrib><creatorcontrib>Du, Xin</creatorcontrib><creatorcontrib>Dong, Jian-Zeng</creatorcontrib><creatorcontrib>Zhou, Xian-Liang</creatorcontrib><creatorcontrib>Ma, Chang-Sheng</creatorcontrib><title>Value of D-dimer and C reactive protein in predicting inhospital death in acute aortic dissection</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><description>Objective To evaluate the role of D-dimer and C reactive protein (CRP) in predicting inhospital death in acute aortic dissection (AD). Design A single-centre prospective study. Setting University hospital in China. Patients 114 patients with acute AD. Intervention Admission D-dimer and CRP concentrations were assayed. Main outcome measures To observe the association of D-dimer and CRP with inhospital death. Results Increased levels of plasma D-dimer (9.84±3.53 vs 4.28±1.99, P < 0.001), CRP (14.08±2.81 vs 11.18±1.85, P < 0.001) and aortic diameter (45.2±9.5 vs 40.3±6.0, p = 0.007) were found in dead patients compared with those survived. Moreover, plasma D-dimer concentrations in type A were higher than that in type B (6.51±4.11 vs 4.87±2.29, p = 0.013). Plasma D-dimer concentrations had positive correlations with CRP levels (r=0.527, P < 0.001) and aortic diameter (r=0.227, p = 0.015), and had negative correlations with the type of AD (r=−0.232, p = 0.013) and the time from onset (r=−0.264, p = 0.005). D-dimer and CRP levels and the type of AD were strongly associated with inhospital mortality. The OR and 95% CI were 3.272, 1.638 to 6.535; 2.322, 1.134 to 4.757; and 0.126, 0.019 to 0.853, respectively. Furthermore, the sensitivity and specificity of D-dimer ≥5.67 μg/mL in predicting inhospital death in acute AD were 90.3% and 75.9% (95% CI 0.85 to 0.96), respectively. Moreover, the sensitivity and specificity of CRP levels ≥11.21 mg/L were 100% and 54.2%, respectively (95% CI 0.74 to 0.89). Conclusions D-dimer ≥5.67 μg/mL, CRP ≥11.21 mg/L and type A acute AD were important risk factors and independently associated with acute AD inhospital death.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aneurysm, Dissecting - blood</subject><subject>Aneurysm, Dissecting - diagnosis</subject><subject>Aneurysm, Dissecting - mortality</subject><subject>Aortic Aneurysm - blood</subject><subject>Aortic Aneurysm - diagnosis</subject><subject>Aortic Aneurysm - mortality</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiovascular disease</subject><subject>Chi-Square Distribution</subject><subject>China</subject><subject>Cholesterol</subject><subject>Diabetes</subject><subject>Dissection</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products - analysis</subject><subject>Hospital Mortality</subject><subject>Hospitalization</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Logistic Models</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Marfan syndrome</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Up-Regulation</subject><subject>Variables</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU1v1DAQhi0Eoh_wDxCyxIVLqMd2bOeItrQgFTgUqt4sJ56wXvKxtR0E_x6v0vbACcmSPTPPjF7PS8grYO8AhDrboot5Nw0VZyAqwSTU5gk5BqnMIXX7tLxFXVeKCX1ETlLaMcZkY9RzcsSFAWFqdkzcjRsWpHNPzysfRozUTZ5uaETX5fAL6T7OGcNEy9lH9KFkpx8l2s5pH7IbqEeXt4ey65aM1M0xh476kBIWdp5ekGe9GxK-vL9PyfeLD982H6urr5efNu-vqlbqJlcevWwUazyXouPYtm3vAVvgvnyN-c5zIWuphOyYUKbxElsOoDloJkRfNnJK3q5zi-K7BVO2Y0gdDoObcF6SBQmguDa1Luibf9DdvMSpqLOgDdNcq1oUSq5UF-eUIvZ2H8Po4h8LzB4ssA8W2IMFdrWgtL2-H760I_rHpoedF6BagZAy_n6su_jTKi10bb_cbCx8vlDX57fGXhf-bOXbcfd_Ev4CJ0ihbw</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Wen, Dan</creator><creator>Du, Xin</creator><creator>Dong, Jian-Zeng</creator><creator>Zhou, Xian-Liang</creator><creator>Ma, Chang-Sheng</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201308</creationdate><title>Value of D-dimer and C reactive protein in predicting inhospital death in acute aortic dissection</title><author>Wen, Dan ; Du, Xin ; Dong, Jian-Zeng ; Zhou, Xian-Liang ; Ma, Chang-Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b479t-ded49609d243c2ebbbfd1eb12d3040dcd23454634c03689d4eb2117217033f113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Aneurysm, Dissecting - blood</topic><topic>Aneurysm, Dissecting - diagnosis</topic><topic>Aneurysm, Dissecting - mortality</topic><topic>Aortic Aneurysm - blood</topic><topic>Aortic Aneurysm - diagnosis</topic><topic>Aortic Aneurysm - mortality</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiovascular disease</topic><topic>Chi-Square Distribution</topic><topic>China</topic><topic>Cholesterol</topic><topic>Diabetes</topic><topic>Dissection</topic><topic>Female</topic><topic>Fibrin Fibrinogen Degradation Products - analysis</topic><topic>Hospital Mortality</topic><topic>Hospitalization</topic><topic>Hospitals, University</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Logistic Models</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Marfan syndrome</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Up-Regulation</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wen, Dan</creatorcontrib><creatorcontrib>Du, Xin</creatorcontrib><creatorcontrib>Dong, Jian-Zeng</creatorcontrib><creatorcontrib>Zhou, Xian-Liang</creatorcontrib><creatorcontrib>Ma, Chang-Sheng</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wen, Dan</au><au>Du, Xin</au><au>Dong, Jian-Zeng</au><au>Zhou, Xian-Liang</au><au>Ma, Chang-Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of D-dimer and C reactive protein in predicting inhospital death in acute aortic dissection</atitle><jtitle>Heart (British Cardiac Society)</jtitle><addtitle>Heart</addtitle><date>2013-08</date><risdate>2013</risdate><volume>99</volume><issue>16</issue><spage>1192</spage><epage>1197</epage><pages>1192-1197</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>Objective To evaluate the role of D-dimer and C reactive protein (CRP) in predicting inhospital death in acute aortic dissection (AD). Design A single-centre prospective study. Setting University hospital in China. Patients 114 patients with acute AD. Intervention Admission D-dimer and CRP concentrations were assayed. Main outcome measures To observe the association of D-dimer and CRP with inhospital death. Results Increased levels of plasma D-dimer (9.84±3.53 vs 4.28±1.99, P < 0.001), CRP (14.08±2.81 vs 11.18±1.85, P < 0.001) and aortic diameter (45.2±9.5 vs 40.3±6.0, p = 0.007) were found in dead patients compared with those survived. Moreover, plasma D-dimer concentrations in type A were higher than that in type B (6.51±4.11 vs 4.87±2.29, p = 0.013). Plasma D-dimer concentrations had positive correlations with CRP levels (r=0.527, P < 0.001) and aortic diameter (r=0.227, p = 0.015), and had negative correlations with the type of AD (r=−0.232, p = 0.013) and the time from onset (r=−0.264, p = 0.005). D-dimer and CRP levels and the type of AD were strongly associated with inhospital mortality. The OR and 95% CI were 3.272, 1.638 to 6.535; 2.322, 1.134 to 4.757; and 0.126, 0.019 to 0.853, respectively. Furthermore, the sensitivity and specificity of D-dimer ≥5.67 μg/mL in predicting inhospital death in acute AD were 90.3% and 75.9% (95% CI 0.85 to 0.96), respectively. Moreover, the sensitivity and specificity of CRP levels ≥11.21 mg/L were 100% and 54.2%, respectively (95% CI 0.74 to 0.89). Conclusions D-dimer ≥5.67 μg/mL, CRP ≥11.21 mg/L and type A acute AD were important risk factors and independently associated with acute AD inhospital death.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>23813850</pmid><doi>10.1136/heartjnl-2013-304158</doi><tpages>6</tpages></addata></record> |
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| subjects | Acute Disease Adult Aneurysm, Dissecting - blood Aneurysm, Dissecting - diagnosis Aneurysm, Dissecting - mortality Aortic Aneurysm - blood Aortic Aneurysm - diagnosis Aortic Aneurysm - mortality Biomarkers - blood C-Reactive Protein - analysis Cardiovascular disease Chi-Square Distribution China Cholesterol Diabetes Dissection Female Fibrin Fibrinogen Degradation Products - analysis Hospital Mortality Hospitalization Hospitals, University Humans Hypertension Logistic Models Low density lipoprotein Male Marfan syndrome Medical prognosis Middle Aged Mortality Multivariate Analysis Odds Ratio Predictive Value of Tests Prognosis Prospective Studies Proteins Risk Assessment Risk Factors Surgery Up-Regulation Variables |
| title | Value of D-dimer and C reactive protein in predicting inhospital death in acute aortic dissection |
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