Preweaning Growth Hormone Treatment Ameliorates Adipose Tissue Insulin Resistance and Inflammation in Adult Male Offspring Following Maternal Undernutrition

It is well established that early-life nutritional alterations lead to increased risk of obesity and metabolic disorders in adult life. Although it is clear that obesity gives rise to chronic low-grade inflammation, there is little evidence regarding the role of inflammation in the adipose tissue of...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2013-08, Vol.154 (8), p.2676-2686
Hauptverfasser:	Reynolds, C. M, Li, M, Gray, C, Vickers, M. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Adipose Tissue - physiopathology Animals Animals, Newborn Anti-inflammatory agents Biological and medical sciences Blood Glucose - metabolism Body fat Body Weight - drug effects Critical period Cytokines - blood Developmental plasticity Diet Diet, High-Fat Explants Female Fundamental and applied biological sciences. Psychology Gene expression Gene Expression - drug effects Glucose Glucose transporter Glucose Transporter Type 4 - genetics Growth Hormone - administration & dosage Growth Hormone - pharmacology Growth hormones High fat diet Inflammation Inflammation - genetics Inflammation - physiopathology Inflammation - prevention & control Insulin Insulin - blood Insulin receptor substrate 1 Insulin Receptor Substrate Proteins - genetics Insulin receptors Insulin Resistance Macrophages Male Males Malnutrition Maternal Nutritional Physiological Phenomena Medical sciences Metabolic diseases Metabolic disorders Metabolism Obesity Offspring Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Pregnancy Random Allocation Rats Rats, Sprague-Dawley Receptor, Insulin - genetics Receptors Reverse Transcriptase Polymerase Chain Reaction Undernutrition Vertebrates: endocrinology Weaning
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