Impact of Divergent Effects of Astaxanthin on Insulin Signaling in L6 Cells

Because oxidative stress promotes insulin resistance in obesity and type 2 diabetes, it is crucial to find effective antioxidant for the purpose of decreasing this threat. In this study, we explored the effect of astaxanthin, a carotenoid antioxidant, on insulin signaling and investigated whether as...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2013-08, Vol.154 (8), p.2600-2612
Hauptverfasser:	Ishiki, Manabu, Nishida, Yasuhiro, Ishibashi, Hiroshi, Wada, Tsutomu, Fujisaka, Shiho, Takikawa, Akiko, Urakaze, Masaharu, Sasaoka, Toshiyasu, Usui, Isao, Tobe, Kazuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid resistance AKT protein alpha-Tocopherol - pharmacology Animals Antioxidants Antioxidants - pharmacology Astaxanthin Biological and medical sciences Blotting, Western c-Jun protein Cell Line Deoxyglucose Deoxyglucose - metabolism Deoxyglucose - pharmacokinetics Diabetes mellitus (non-insulin dependent) Extracellular signal-regulated kinase Fundamental and applied biological sciences. Psychology Glucose Glucose transporter Glucose Transporter Type 4 - metabolism Hypoglycemic Agents - pharmacology Impact resistance Insulin Insulin - pharmacology Insulin Receptor Substrate Proteins - metabolism Insulin receptors Insulin resistance Insulin Resistance - physiology JNK Mitogen-Activated Protein Kinases - metabolism JNK protein Kinases Lipoic acid Myoblasts - cytology Myoblasts - drug effects Myoblasts - metabolism Oxidation resistance Oxidative stress Oxygen Palmitic acid Phosphorylation Phosphorylation - drug effects Protein Transport - drug effects Proto-Oncogene Proteins c-akt - metabolism Rats Reactive oxygen species Reactive Oxygen Species - metabolism Receptors Signal Transduction - drug effects Thioctic Acid - pharmacology Tocopherol Transcription factors Translocation Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-α Tyrosine Vertebrates: endocrinology Xanthophylls - pharmacology
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