Ecto-5′-Nucleotidase on Immune Cells Protects From Adverse Cardiac Remodeling

RATIONALE:Ecto-5′-nucleotidase (CD73) on immune cells is emerging as a critical pathway and therapeutic target in cardiovascular and autoimmune disorders. OBJECTIVE:Here, we investigated the role of CD73 in postinfarction inflammation, cardiac repair, and remodeling in mice after reperfused myocardi...

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Veröffentlicht in:	Circulation research 2013-07, Vol.113 (3), p.301-312
Hauptverfasser:	Bönner, Florian, Borg, Nadine, Jacoby, Christoph, Temme, Sebastian, Ding, Zhaoping, Flögel, Ulrich, Schrader, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	5'-Nucleotidase - biosynthesis 5'-Nucleotidase - genetics Animals Immunity, Cellular - physiology Male Mice Mice, Inbred C57BL Mice, Knockout Myocardial Reperfusion Injury - enzymology Myocardial Reperfusion Injury - pathology Ventricular Remodeling - physiology
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