Nonrelapse Mortality and Mycophenolic Acid Exposure in Nonmyeloablative Hematopoietic Cell Transplantation

Abstract We evaluated the pharmacodynamic relationships between mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), and outcomes in 308 patients after nonmyeloablative hematopoietic cell transplantation. Patients were conditioned with total body irradiation ± fludarabine,...

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Veröffentlicht in:	Biology of blood and marrow transplantation 2013-08, Vol.19 (8), p.1159-1166
Hauptverfasser:	McDermott, Cara L, Sandmaier, Brenda M, Storer, Barry, Li, Hong, Mager, Donald E, Boeckh, Michael J, Bemer, Meagan J, Knutson, Jennifer, McCune, Jeannine S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Bayes Theorem Bayesian Cohort Studies Female Graft versus host disease Graft vs Host Disease - chemically induced Graft vs Host Disease - etiology Graft vs Host Disease - mortality Hematology, Oncology and Palliative Medicine Hematopoietic cell transplant Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cell Transplantation - mortality Humans Male Middle Aged Mycophenolic acid Mycophenolic Acid - administration & dosage Mycophenolic Acid - adverse effects Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - metabolism Mycophenolic Acid - pharmacokinetics Pharmacokinetics Retrospective Studies Transplantation Conditioning - methods Young Adult
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