Correlation of Echocardiographic Left Atrial Abnormality With Myocardial Ischemia During Myocardial Perfusion Assessment in the Presence of Known Left Ventricular Hypertrophy
Left atrial (LA) abnormality, an easily quantifiable parameter of left ventricular (LV) diastolic dysfunction, has been associated with cardiovascular risk similar to that of LV hypertrophy. The correlation between LV hypertrophy and LA abnormality among patients undergoing myocardial perfusion (MP)...
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| Veröffentlicht in: | The American journal of cardiology 2013-08, Vol.112 (3), p.416-419 |
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| creator | Nawathe, Amar, MD Ariyarajah, Vignendra, MD Apiyasawat, Sirin, MD Barac, Ivan, MD Spodick, David H., MD, DSc |
| description | Left atrial (LA) abnormality, an easily quantifiable parameter of left ventricular (LV) diastolic dysfunction, has been associated with cardiovascular risk similar to that of LV hypertrophy. The correlation between LV hypertrophy and LA abnormality among patients undergoing myocardial perfusion (MP) study has not been described. We prospectively studied 78 consecutive patients with LV hypertrophy who underwent MP study after screening for electrocardiographic and echocardiographic LA abnormality over a 6-month period. Of those, 48 had a positive MP imaging result, and 30 did not. LA size (p = 0.002) and P-wave duration (p = 0.017) were significantly increased in the former. The differential change in LA size (no defect = 35 ± 4, mild = 36 ± 5, moderate = 38 ± 5, severe = 44 ± 5 mm; p |
| doi_str_mv | 10.1016/j.amjcard.2013.03.047 |
| format | Article |
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The correlation between LV hypertrophy and LA abnormality among patients undergoing myocardial perfusion (MP) study has not been described. We prospectively studied 78 consecutive patients with LV hypertrophy who underwent MP study after screening for electrocardiographic and echocardiographic LA abnormality over a 6-month period. Of those, 48 had a positive MP imaging result, and 30 did not. LA size (p = 0.002) and P-wave duration (p = 0.017) were significantly increased in the former. The differential change in LA size (no defect = 35 ± 4, mild = 36 ± 5, moderate = 38 ± 5, severe = 44 ± 5 mm; p <0.0001) and P-wave duration (no defect = 107 ± 14, mild = 110 ± 17, moderate = 113 ± 15, severe = 127 ± 22 ms; p = 0.003) was greatest when the MP study defect exceeded moderate severity. In conclusion, the presence of LA abnormality could assist during MP study interpretation among patients with LV hypertrophy when such markers appear to be correlated with the severity of the MP study defect.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2013.03.047</identifier><identifier>PMID: 23870178</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Cardiovascular ; Cardiovascular disease ; Chronic obstructive pulmonary disease ; Comorbidity ; Confidence intervals ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - physiopathology ; Coronary Circulation - physiology ; Defects ; Diastole - physiology ; Dipyridamole ; Echocardiography ; Electrocardiography ; Exercise Test ; Female ; Heart Atria - diagnostic imaging ; Heart Atria - physiopathology ; Heart attacks ; Humans ; Hypertension - diagnostic imaging ; Hypertension - physiopathology ; Hypertrophy, Left Ventricular - diagnostic imaging ; Hypertrophy, Left Ventricular - physiopathology ; Ischemia ; Male ; Middle Aged ; Morbidity ; Myocardial Ischemia - diagnostic imaging ; Myocardial Ischemia - physiopathology ; Prospective Studies ; Signal Processing, Computer-Assisted ; Statistics as Topic ; Tomography, Emission-Computed, Single-Photon ; Variables ; Vasodilator Agents ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>The American journal of cardiology, 2013-08, Vol.112 (3), p.416-419</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Aug 1, 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-293458472f5b9d2bc95139b7db05d1c0d24e745adcf48be33ae8b752bb8fdfcb3</citedby><cites>FETCH-LOGICAL-c448t-293458472f5b9d2bc95139b7db05d1c0d24e745adcf48be33ae8b752bb8fdfcb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002914913009089$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23870178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nawathe, Amar, MD</creatorcontrib><creatorcontrib>Ariyarajah, Vignendra, MD</creatorcontrib><creatorcontrib>Apiyasawat, Sirin, MD</creatorcontrib><creatorcontrib>Barac, Ivan, MD</creatorcontrib><creatorcontrib>Spodick, David H., MD, DSc</creatorcontrib><title>Correlation of Echocardiographic Left Atrial Abnormality With Myocardial Ischemia During Myocardial Perfusion Assessment in the Presence of Known Left Ventricular Hypertrophy</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>Left atrial (LA) abnormality, an easily quantifiable parameter of left ventricular (LV) diastolic dysfunction, has been associated with cardiovascular risk similar to that of LV hypertrophy. The correlation between LV hypertrophy and LA abnormality among patients undergoing myocardial perfusion (MP) study has not been described. We prospectively studied 78 consecutive patients with LV hypertrophy who underwent MP study after screening for electrocardiographic and echocardiographic LA abnormality over a 6-month period. Of those, 48 had a positive MP imaging result, and 30 did not. LA size (p = 0.002) and P-wave duration (p = 0.017) were significantly increased in the former. The differential change in LA size (no defect = 35 ± 4, mild = 36 ± 5, moderate = 38 ± 5, severe = 44 ± 5 mm; p <0.0001) and P-wave duration (no defect = 107 ± 14, mild = 110 ± 17, moderate = 113 ± 15, severe = 127 ± 22 ms; p = 0.003) was greatest when the MP study defect exceeded moderate severity. In conclusion, the presence of LA abnormality could assist during MP study interpretation among patients with LV hypertrophy when such markers appear to be correlated with the severity of the MP study defect.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Comorbidity</subject><subject>Confidence intervals</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Coronary Circulation - physiology</subject><subject>Defects</subject><subject>Diastole - physiology</subject><subject>Dipyridamole</subject><subject>Echocardiography</subject><subject>Electrocardiography</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Heart Atria - diagnostic imaging</subject><subject>Heart Atria - physiopathology</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Hypertension - diagnostic imaging</subject><subject>Hypertension - physiopathology</subject><subject>Hypertrophy, Left Ventricular - diagnostic imaging</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>Ischemia</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Myocardial Ischemia - diagnostic imaging</subject><subject>Myocardial Ischemia - physiopathology</subject><subject>Prospective Studies</subject><subject>Signal Processing, Computer-Assisted</subject><subject>Statistics as Topic</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>Variables</subject><subject>Vasodilator Agents</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFktuKFDEQhhtR3HH1EZSAN97MmKTTh9wow7i6iyMueLoMSbp6O2N3MiZppV_KZzRNjwf2RigIob6qP6m_suwxwRuCSfn8sJHDQUvfbCgm-QanYNWdbEXqiq8JJ_ndbIUxpmtOGD_LHoRwSFdCivJ-dkbzusKkqlfZz53zHnoZjbPItehCd27uatyNl8fOaLSHNqJt9Eb2aKus84PsTZzQFxM79G5a6JS7CrqDwUj0avTG3vybugbfjmFW2IYAIQxgIzIWxQ7QtYcAVsMs_ta6H3YR_JwQb_TYS48upyP46N2xmx5m91rZB3h0Os-zT68vPu4u1_v3b6522_1aM1bHNeU5K2pW0bZQvKFK84LkXFWNwkVDNG4og4oVstEtqxXkuYRaVQVVqm6bVqv8PHu29D16922EEMVggoa-lxbcGARhhJS0JHWR0Ke30IMbvU2vSxTGrGC8pIkqFkp7F4KHVhy9GaSfBMFiNlQcxMlQMRsqcApWpbonp-6jGqD5U_XbwQS8XABI4_huwIugzTzQxnjQUTTO_Ffixa0OujfWaNl_hQnC39-IQAUWH-atmpeK5BhzXPP8F7F4zMM</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Nawathe, Amar, MD</creator><creator>Ariyarajah, Vignendra, MD</creator><creator>Apiyasawat, Sirin, MD</creator><creator>Barac, Ivan, MD</creator><creator>Spodick, David H., MD, DSc</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20130801</creationdate><title>Correlation of Echocardiographic Left Atrial Abnormality With Myocardial Ischemia During Myocardial Perfusion Assessment in the Presence of Known Left Ventricular Hypertrophy</title><author>Nawathe, Amar, MD ; Ariyarajah, Vignendra, MD ; Apiyasawat, Sirin, MD ; Barac, Ivan, MD ; Spodick, David H., MD, DSc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-293458472f5b9d2bc95139b7db05d1c0d24e745adcf48be33ae8b752bb8fdfcb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Comorbidity</topic><topic>Confidence intervals</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Coronary Circulation - physiology</topic><topic>Defects</topic><topic>Diastole - physiology</topic><topic>Dipyridamole</topic><topic>Echocardiography</topic><topic>Electrocardiography</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Heart Atria - diagnostic imaging</topic><topic>Heart Atria - physiopathology</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Hypertension - diagnostic imaging</topic><topic>Hypertension - physiopathology</topic><topic>Hypertrophy, Left Ventricular - diagnostic imaging</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>Ischemia</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Myocardial Ischemia - diagnostic imaging</topic><topic>Myocardial Ischemia - physiopathology</topic><topic>Prospective Studies</topic><topic>Signal Processing, Computer-Assisted</topic><topic>Statistics as Topic</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>Variables</topic><topic>Vasodilator Agents</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nawathe, Amar, MD</creatorcontrib><creatorcontrib>Ariyarajah, Vignendra, MD</creatorcontrib><creatorcontrib>Apiyasawat, Sirin, MD</creatorcontrib><creatorcontrib>Barac, Ivan, MD</creatorcontrib><creatorcontrib>Spodick, David H., MD, DSc</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biochemistry Abstracts 1</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nawathe, Amar, MD</au><au>Ariyarajah, Vignendra, MD</au><au>Apiyasawat, Sirin, MD</au><au>Barac, Ivan, MD</au><au>Spodick, David H., MD, DSc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of Echocardiographic Left Atrial Abnormality With Myocardial Ischemia During Myocardial Perfusion Assessment in the Presence of Known Left Ventricular Hypertrophy</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>112</volume><issue>3</issue><spage>416</spage><epage>419</epage><pages>416-419</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Left atrial (LA) abnormality, an easily quantifiable parameter of left ventricular (LV) diastolic dysfunction, has been associated with cardiovascular risk similar to that of LV hypertrophy. The correlation between LV hypertrophy and LA abnormality among patients undergoing myocardial perfusion (MP) study has not been described. We prospectively studied 78 consecutive patients with LV hypertrophy who underwent MP study after screening for electrocardiographic and echocardiographic LA abnormality over a 6-month period. Of those, 48 had a positive MP imaging result, and 30 did not. LA size (p = 0.002) and P-wave duration (p = 0.017) were significantly increased in the former. The differential change in LA size (no defect = 35 ± 4, mild = 36 ± 5, moderate = 38 ± 5, severe = 44 ± 5 mm; p <0.0001) and P-wave duration (no defect = 107 ± 14, mild = 110 ± 17, moderate = 113 ± 15, severe = 127 ± 22 ms; p = 0.003) was greatest when the MP study defect exceeded moderate severity. In conclusion, the presence of LA abnormality could assist during MP study interpretation among patients with LV hypertrophy when such markers appear to be correlated with the severity of the MP study defect.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23870178</pmid><doi>10.1016/j.amjcard.2013.03.047</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Cardiovascular Cardiovascular disease Chronic obstructive pulmonary disease Comorbidity Confidence intervals Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - physiopathology Coronary Circulation - physiology Defects Diastole - physiology Dipyridamole Echocardiography Electrocardiography Exercise Test Female Heart Atria - diagnostic imaging Heart Atria - physiopathology Heart attacks Humans Hypertension - diagnostic imaging Hypertension - physiopathology Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - physiopathology Ischemia Male Middle Aged Morbidity Myocardial Ischemia - diagnostic imaging Myocardial Ischemia - physiopathology Prospective Studies Signal Processing, Computer-Assisted Statistics as Topic Tomography, Emission-Computed, Single-Photon Variables Vasodilator Agents Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - physiopathology |
| title | Correlation of Echocardiographic Left Atrial Abnormality With Myocardial Ischemia During Myocardial Perfusion Assessment in the Presence of Known Left Ventricular Hypertrophy |
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