Interaction of sea cucumber saponins with multilamellar liposomes
The effect of three sea cucumber saponins, echinoside A, bivittoside D and holothurin A, on multilamellar liposomes was investigated. An ideal osmotic behavior of liposomes was described as a linear relationship between the reciprocal 3 2 s power of absorbance at 450 nm and the osmotic gradient acro...
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| Veröffentlicht in: | Chemico-biological interactions 1984-01, Vol.52 (2), p.185-202 |
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| container_title | Chemico-biological interactions |
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| creator | Yu, Byung Sul Jo, In-Ho |
| description | The effect of three sea cucumber saponins, echinoside A, bivittoside D and holothurin A, on multilamellar liposomes was investigated. An ideal osmotic behavior of liposomes was described as a linear relationship between the reciprocal
3
2
s
power of absorbance at 450 nm and the osmotic gradient across the membrane. Sea cucumber saponins at concentrations below critical micelle concentration (CMC) disturbed this linear relationship in liposomes composed of egg phosphatidylcholine, phosphatidic acid and cholesterol. Cholesterol-free liposomes were not susceptible to these saponins. Results of optical measurements were consistent with those of transmission electron microscopy, which showed saponin-induced changes in liposomal structure. The lytic activity of sea cucumber saponins on liposomes depended on their chemical structure.
These results suggest that sea cucumber saponins as monomers can interact with liposomes and that cholesterol serve as a principal binding site for the sea cucumber saponins. |
| doi_str_mv | 10.1016/0009-2797(84)90072-3 |
| format | Article |
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3
2
s
power of absorbance at 450 nm and the osmotic gradient across the membrane. Sea cucumber saponins at concentrations below critical micelle concentration (CMC) disturbed this linear relationship in liposomes composed of egg phosphatidylcholine, phosphatidic acid and cholesterol. Cholesterol-free liposomes were not susceptible to these saponins. Results of optical measurements were consistent with those of transmission electron microscopy, which showed saponin-induced changes in liposomal structure. The lytic activity of sea cucumber saponins on liposomes depended on their chemical structure.
These results suggest that sea cucumber saponins as monomers can interact with liposomes and that cholesterol serve as a principal binding site for the sea cucumber saponins.</description><identifier>ISSN: 0009-2797</identifier><identifier>EISSN: 1872-7786</identifier><identifier>DOI: 10.1016/0009-2797(84)90072-3</identifier><identifier>PMID: 6509686</identifier><identifier>CODEN: CBINA8</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Cell membranes. Ionic channels. Membrane pores ; Cell structures and functions ; Cholesterol ; Fundamental and applied biological sciences. Psychology ; Holothurin - analogs & derivatives ; Holothuroidea ; Kinetics ; Liposomes ; Marine ; Microscopy, Electron ; Molecular and cellular biology ; Molecular Conformation ; Multilamellar liposomes - Osmotic behavior - Sea cucumber saponins ; Phosphatidic Acids ; Phosphatidylcholines ; Saponins ; Sea Cucumbers ; Structure-Activity Relationship</subject><ispartof>Chemico-biological interactions, 1984-01, Vol.52 (2), p.185-202</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-58d6af6a517d48de47a8f9b602ce9c9fa78b1b4c615a47ec1d5141d37d328af3</citedby><cites>FETCH-LOGICAL-c446t-58d6af6a517d48de47a8f9b602ce9c9fa78b1b4c615a47ec1d5141d37d328af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0009-2797(84)90072-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8946131$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6509686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Byung Sul</creatorcontrib><creatorcontrib>Jo, In-Ho</creatorcontrib><title>Interaction of sea cucumber saponins with multilamellar liposomes</title><title>Chemico-biological interactions</title><addtitle>Chem Biol Interact</addtitle><description>The effect of three sea cucumber saponins, echinoside A, bivittoside D and holothurin A, on multilamellar liposomes was investigated. An ideal osmotic behavior of liposomes was described as a linear relationship between the reciprocal
3
2
s
power of absorbance at 450 nm and the osmotic gradient across the membrane. Sea cucumber saponins at concentrations below critical micelle concentration (CMC) disturbed this linear relationship in liposomes composed of egg phosphatidylcholine, phosphatidic acid and cholesterol. Cholesterol-free liposomes were not susceptible to these saponins. Results of optical measurements were consistent with those of transmission electron microscopy, which showed saponin-induced changes in liposomal structure. The lytic activity of sea cucumber saponins on liposomes depended on their chemical structure.
These results suggest that sea cucumber saponins as monomers can interact with liposomes and that cholesterol serve as a principal binding site for the sea cucumber saponins.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell membranes. Ionic channels. Membrane pores</subject><subject>Cell structures and functions</subject><subject>Cholesterol</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Holothurin - analogs & derivatives</subject><subject>Holothuroidea</subject><subject>Kinetics</subject><subject>Liposomes</subject><subject>Marine</subject><subject>Microscopy, Electron</subject><subject>Molecular and cellular biology</subject><subject>Molecular Conformation</subject><subject>Multilamellar liposomes - Osmotic behavior - Sea cucumber saponins</subject><subject>Phosphatidic Acids</subject><subject>Phosphatidylcholines</subject><subject>Saponins</subject><subject>Sea Cucumbers</subject><subject>Structure-Activity Relationship</subject><issn>0009-2797</issn><issn>1872-7786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo67r6DxR6ENFDNWnTJL0Iy-LHwoKXvYc0mWCkbdakVfz3tm7Zo6eZYZ4ZXh6ELgm-J5iwB4xxmWa85LeC3pUY8yzNj9CciKHhXLBjND8gp-gsxo9hxBnFMzRjBS6ZYHO0XLcdBKU759vE2ySCSnSv-6aCkES1861rY_Ltuvek6evO1aqBulYhqd3OR99APEcnVtURLqa6QNvnp-3qNd28vaxXy02qKWVdWgjDlGWqINxQYYByJWxZMZxpKHVpFRcVqahmpFCUgyamIJSYnJs8E8rmC3Szf7sL_rOH2MnGRT1macH3UQ4wKQrCBpDuQR18jAGs3AXXqPAjCZajODlakaMVKaj8Eyfz4exq-t9XDZjD0WRq2F9PexW1qm1QrXbxgImSMpKTAXvcYzCo-HIQZNQOWg3GBdCdNN79n-MXieuKEw</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Yu, Byung Sul</creator><creator>Jo, In-Ho</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope></search><sort><creationdate>19840101</creationdate><title>Interaction of sea cucumber saponins with multilamellar liposomes</title><author>Yu, Byung Sul ; Jo, In-Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-58d6af6a517d48de47a8f9b602ce9c9fa78b1b4c615a47ec1d5141d37d328af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell membranes. Ionic channels. Membrane pores</topic><topic>Cell structures and functions</topic><topic>Cholesterol</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Holothurin - analogs & derivatives</topic><topic>Holothuroidea</topic><topic>Kinetics</topic><topic>Liposomes</topic><topic>Marine</topic><topic>Microscopy, Electron</topic><topic>Molecular and cellular biology</topic><topic>Molecular Conformation</topic><topic>Multilamellar liposomes - Osmotic behavior - Sea cucumber saponins</topic><topic>Phosphatidic Acids</topic><topic>Phosphatidylcholines</topic><topic>Saponins</topic><topic>Sea Cucumbers</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Byung Sul</creatorcontrib><creatorcontrib>Jo, In-Ho</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Chemico-biological interactions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Byung Sul</au><au>Jo, In-Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction of sea cucumber saponins with multilamellar liposomes</atitle><jtitle>Chemico-biological interactions</jtitle><addtitle>Chem Biol Interact</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>52</volume><issue>2</issue><spage>185</spage><epage>202</epage><pages>185-202</pages><issn>0009-2797</issn><eissn>1872-7786</eissn><coden>CBINA8</coden><abstract>The effect of three sea cucumber saponins, echinoside A, bivittoside D and holothurin A, on multilamellar liposomes was investigated. An ideal osmotic behavior of liposomes was described as a linear relationship between the reciprocal
3
2
s
power of absorbance at 450 nm and the osmotic gradient across the membrane. Sea cucumber saponins at concentrations below critical micelle concentration (CMC) disturbed this linear relationship in liposomes composed of egg phosphatidylcholine, phosphatidic acid and cholesterol. Cholesterol-free liposomes were not susceptible to these saponins. Results of optical measurements were consistent with those of transmission electron microscopy, which showed saponin-induced changes in liposomal structure. The lytic activity of sea cucumber saponins on liposomes depended on their chemical structure.
These results suggest that sea cucumber saponins as monomers can interact with liposomes and that cholesterol serve as a principal binding site for the sea cucumber saponins.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>6509686</pmid><doi>10.1016/0009-2797(84)90072-3</doi><tpages>18</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-2797 |
| ispartof | Chemico-biological interactions, 1984-01, Vol.52 (2), p.185-202 |
| issn | 0009-2797 1872-7786 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Cell membranes. Ionic channels. Membrane pores Cell structures and functions Cholesterol Fundamental and applied biological sciences. Psychology Holothurin - analogs & derivatives Holothuroidea Kinetics Liposomes Marine Microscopy, Electron Molecular and cellular biology Molecular Conformation Multilamellar liposomes - Osmotic behavior - Sea cucumber saponins Phosphatidic Acids Phosphatidylcholines Saponins Sea Cucumbers Structure-Activity Relationship |
| title | Interaction of sea cucumber saponins with multilamellar liposomes |
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