5-Azacytidine potentiates initiation induced by carcinogens in rat liver

To test the validity of the hypothesis that hypomethylation of DNA plays an important role in the initiation of carcinogenic process, 5-azacytidine (5-AzC) (10 mg/kg), an inhibitor of DNA methylation, was given to rats during the phase of repair synthesis induced by the three carcinogens, benzo[a]-p...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Carcinogenesis (New York) 1985-01, Vol.6 (1), p.145-146
Hauptverfasser:	Denda, A., Rao, Prema M., Rajalakshmi, S., Sarma, D.S.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azacitidine - toxicity Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogens Chemical agents Cocarcinogenesis DNA - metabolism gamma-Glutamyltransferase - analysis Liver - enzymology Liver Neoplasms, Experimental - chemically induced Medical sciences Methylation Rats Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!