Absence of a promoting or sequential syncarcinogenic effect in rat liver by the carcinogenic hypolipidemic drug nafenopin given after N-2-fluorenylacetamide

The hypolipidemic agent nafenopin, (NF), has been reported to be carcinogenic to rat liver. To determine whether nafenopin exerts a promoting or syncarcinogenic effect in rat liver, its effect on liver carcinogenesis induced by N-2-fluorenylacetamide (FAA) was studied. In two separate experiments, m...

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Veröffentlicht in:	Toxicology and applied pharmacology 1985, Vol.77 (1), p.76-85
Hauptverfasser:	Numoto, Satoshi, Mori, Hideki, Furuya, Keizo, Levine, Walter G., Williams, Gary M.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Acetylaminofluorene - toxicity Administration, Oral Animals Biological and medical sciences Body Weight - drug effects Carcinogens Drug Synergism Drug toxicity and drugs side effects treatment Liver Neoplasms - chemically induced Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Nafenopin - toxicity Neoplasms, Experimental - chemically induced Pharmacology. Drug treatments Phenobarbital - toxicity Propionates - toxicity Rats Rats, Inbred F344
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