Fluorescence polarization analysis, lipid composition, and Na super(+), K super(+)-ATPase kinetics of synaptosomal membranes in feline GM sub(1) and GM sub(2) gangliosidosis

Neurochemical studies were performed on synaptosomal membranes from cats with GM sub(1) or GM sub(2) gangliosidosis to examine possible mechanisms of neuronal dysfunction in these disorders. The basic hypothesis tested was that deficient ganglioside catabolism causes increased ganglioside content of...

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Veröffentlicht in:	Journal of neurochemistry 1985-01, Vol.44 (3), p.947-956
Hauptverfasser:	Wood, P A, McBride, M R, Baker, HJ, Christian, ST
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Sprache:	eng
Schlagworte:	adenosinetriphosphatase brain cats ganglioside GM1 ganglioside GM2
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creator	Wood, P A McBride, M R Baker, HJ Christian, ST
description	Neurochemical studies were performed on synaptosomal membranes from cats with GM sub(1) or GM sub(2) gangliosidosis to examine possible mechanisms of neuronal dysfunction in these disorders. The basic hypothesis tested was that deficient ganglioside catabolism causes increased ganglioside content of synaptosomal plasma membrane which in turn disrupts normal function. The observations provide evidence for a pathogenetic mechanism of neuronal dysfunction in the gangliosidoses while demonstrating protection of certain vital functional components, such as Na super(+), K super(+)-ATPase.
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identifier	ISSN: 0022-3042
ispartof	Journal of neurochemistry, 1985-01, Vol.44 (3), p.947-956
issn	0022-3042
language	eng
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source	Wiley Online Library Journals Frontfile Complete
subjects	adenosinetriphosphatase brain cats ganglioside GM1 ganglioside GM2
title	Fluorescence polarization analysis, lipid composition, and Na super(+), K super(+)-ATPase kinetics of synaptosomal membranes in feline GM sub(1) and GM sub(2) gangliosidosis
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