Biochemical indices of cyclophosphamide-induced lung toxicity

Cyclophosphamide (CP) requires metabolic activation for its therapeutic action, and this metabolism results in the formation of two toxic metabolites, acrolein (ACR) and phosphoramide mustard (PM). To determine which metabolite is responsible for CP-induced lung injury, biochemical indices of toxici...

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Veröffentlicht in:	Toxicology and applied pharmacology 1984-10, Vol.76 (1), p.128-138
Hauptverfasser:	Patel, J.M., Block, E.R., Hood, C.I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Hydroxylase - metabolism Animals Biological and medical sciences Cyclophosphamide - pharmacology Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Glutathione - analysis Lipid Peroxides - biosynthesis Lung - analysis Lung - drug effects Male Medical sciences Microsomes - drug effects Mixed Function Oxygenases - metabolism NADPH-Ferrihemoprotein Reductase - metabolism Pharmacology. Drug treatments Phenobarbital - pharmacology Rats Toxicity: respiratory system, ent, stomatology
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