Response of Rats to Repeated Oral Administration of Endosulfan
Male and female albino rats given different oral doses (0.75, 2.5, 5.0 and 0.25, 0.75, 1.5 mg/kg/D) of endosulfan respectively for a period of 30 days elicited signs of toxicity such as hyperexcitability, tremor, dyspnea and salivation for a brief period. At the tested dose levels, endosulfan produc...
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| Veröffentlicht in: | Industrial Health 1984, Vol.22(4), pp.295-304 |
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| creator | DIKSHITH, T.S.S. RAIZADA, R.B. SRIVASTAVA, M.K. KAPHALIA, B.S. |
| description | Male and female albino rats given different oral doses (0.75, 2.5, 5.0 and 0.25, 0.75, 1.5 mg/kg/D) of endosulfan respectively for a period of 30 days elicited signs of toxicity such as hyperexcitability, tremor, dyspnea and salivation for a brief period. At the tested dose levels, endosulfan produced no significant change in the organ body weight ratio, biochemical, histological, haematological and fertility indices. Residue analysis using GLC techniques of different organs revealed a higher level of α isomer in the fatty tissue of male and female rats, than in other organs. There was no significant accumulation of the α and β iso-mers of endosulfan in the vital organs inspite of repeated exposure which seems to be the reason for the absence of a severe toxicological response in the rats. The lower doses of endosulfan, however, showed none of the toxicological effects in male (0.75 and 2.5 mg/kg/D) and female (0.25 and 0.75 mg/kg/D) rats. |
| doi_str_mv | 10.2486/indhealth.22.295 |
| format | Article |
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At the tested dose levels, endosulfan produced no significant change in the organ body weight ratio, biochemical, histological, haematological and fertility indices. Residue analysis using GLC techniques of different organs revealed a higher level of α isomer in the fatty tissue of male and female rats, than in other organs. There was no significant accumulation of the α and β iso-mers of endosulfan in the vital organs inspite of repeated exposure which seems to be the reason for the absence of a severe toxicological response in the rats. The lower doses of endosulfan, however, showed none of the toxicological effects in male (0.75 and 2.5 mg/kg/D) and female (0.25 and 0.75 mg/kg/D) rats.</description><identifier>ISSN: 0019-8366</identifier><identifier>EISSN: 1880-8026</identifier><identifier>DOI: 10.2486/indhealth.22.295</identifier><identifier>PMID: 6526703</identifier><language>eng</language><publisher>Japan: National Institute of Occupational Safety and Health</publisher><subject>Administration, Oral ; Animals ; Body Weight - drug effects ; Chemical Phenomena ; Chemistry ; Endosulfan ; Endosulfan - administration & dosage ; Endosulfan - toxicity ; Female ; Fertility ; Fertility - drug effects ; Male ; Male and female rat ; Oral toxicity ; Organ Size - drug effects ; Rats ; Rats, Inbred Strains ; Residue</subject><ispartof>Industrial Health, 1984, Vol.22(4), pp.295-304</ispartof><rights>National Institute of Occupational Safety and Health</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4715-e7529df45cb0b284fa4b56f13233daa9fc51ea1b367e3dc97f45e5565b2659a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6526703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DIKSHITH, T.S.S.</creatorcontrib><creatorcontrib>RAIZADA, R.B.</creatorcontrib><creatorcontrib>SRIVASTAVA, M.K.</creatorcontrib><creatorcontrib>KAPHALIA, B.S.</creatorcontrib><title>Response of Rats to Repeated Oral Administration of Endosulfan</title><title>Industrial Health</title><addtitle>Ind Health</addtitle><description>Male and female albino rats given different oral doses (0.75, 2.5, 5.0 and 0.25, 0.75, 1.5 mg/kg/D) of endosulfan respectively for a period of 30 days elicited signs of toxicity such as hyperexcitability, tremor, dyspnea and salivation for a brief period. At the tested dose levels, endosulfan produced no significant change in the organ body weight ratio, biochemical, histological, haematological and fertility indices. Residue analysis using GLC techniques of different organs revealed a higher level of α isomer in the fatty tissue of male and female rats, than in other organs. There was no significant accumulation of the α and β iso-mers of endosulfan in the vital organs inspite of repeated exposure which seems to be the reason for the absence of a severe toxicological response in the rats. The lower doses of endosulfan, however, showed none of the toxicological effects in male (0.75 and 2.5 mg/kg/D) and female (0.25 and 0.75 mg/kg/D) rats.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Body Weight - drug effects</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Endosulfan</subject><subject>Endosulfan - administration & dosage</subject><subject>Endosulfan - toxicity</subject><subject>Female</subject><subject>Fertility</subject><subject>Fertility - drug effects</subject><subject>Male</subject><subject>Male and female rat</subject><subject>Oral toxicity</subject><subject>Organ Size - drug effects</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Residue</subject><issn>0019-8366</issn><issn>1880-8026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AQhhdRaq3evQg5eUvdj-wmexFKqVooFErvyySZ2JR8ubs5-O9NaYiXmcP7zMvwEPLM6JJHiXorm_yEUPnTkvMl1_KGzFmS0DChXN2SOaVMh4lQ6p48OHemVCipxYzMlOQqpmJO3g_ourZxGLRFcADvAt8GB-wQPObB3kIVrPK6bErnLfiybS7cpslb11cFNI_kroDK4dO4F-T4sTmuv8Ld_nO7Xu3CLIqZDDGWXOdFJLOUpjyJCohSqQomuBA5gC4yyRBYKlSMIs90PKAopZIpHx4GsSCv19rOtj89Om_q0mVYVdBg2zvDIkY5S-gA0iuY2dY5i4XpbFmD_TWMmosxMxkznJvB2HDyMnb3aY35dDAqGvLtNT87D9845WB9mVX4X8i0EpfSaBxaTkx2AmuwEX8ZjoMn</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>DIKSHITH, T.S.S.</creator><creator>RAIZADA, R.B.</creator><creator>SRIVASTAVA, M.K.</creator><creator>KAPHALIA, B.S.</creator><general>National Institute of Occupational Safety and Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1984</creationdate><title>Response of Rats to Repeated Oral Administration of Endosulfan</title><author>DIKSHITH, T.S.S. ; RAIZADA, R.B. ; SRIVASTAVA, M.K. ; KAPHALIA, B.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4715-e7529df45cb0b284fa4b56f13233daa9fc51ea1b367e3dc97f45e5565b2659a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Body Weight - drug effects</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Endosulfan</topic><topic>Endosulfan - administration & dosage</topic><topic>Endosulfan - toxicity</topic><topic>Female</topic><topic>Fertility</topic><topic>Fertility - drug effects</topic><topic>Male</topic><topic>Male and female rat</topic><topic>Oral toxicity</topic><topic>Organ Size - drug effects</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Residue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DIKSHITH, T.S.S.</creatorcontrib><creatorcontrib>RAIZADA, R.B.</creatorcontrib><creatorcontrib>SRIVASTAVA, M.K.</creatorcontrib><creatorcontrib>KAPHALIA, B.S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Industrial Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DIKSHITH, T.S.S.</au><au>RAIZADA, R.B.</au><au>SRIVASTAVA, M.K.</au><au>KAPHALIA, B.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response of Rats to Repeated Oral Administration of Endosulfan</atitle><jtitle>Industrial Health</jtitle><addtitle>Ind Health</addtitle><date>1984</date><risdate>1984</risdate><volume>22</volume><issue>4</issue><spage>295</spage><epage>304</epage><pages>295-304</pages><issn>0019-8366</issn><eissn>1880-8026</eissn><abstract>Male and female albino rats given different oral doses (0.75, 2.5, 5.0 and 0.25, 0.75, 1.5 mg/kg/D) of endosulfan respectively for a period of 30 days elicited signs of toxicity such as hyperexcitability, tremor, dyspnea and salivation for a brief period. At the tested dose levels, endosulfan produced no significant change in the organ body weight ratio, biochemical, histological, haematological and fertility indices. Residue analysis using GLC techniques of different organs revealed a higher level of α isomer in the fatty tissue of male and female rats, than in other organs. There was no significant accumulation of the α and β iso-mers of endosulfan in the vital organs inspite of repeated exposure which seems to be the reason for the absence of a severe toxicological response in the rats. The lower doses of endosulfan, however, showed none of the toxicological effects in male (0.75 and 2.5 mg/kg/D) and female (0.25 and 0.75 mg/kg/D) rats.</abstract><cop>Japan</cop><pub>National Institute of Occupational Safety and Health</pub><pmid>6526703</pmid><doi>10.2486/indhealth.22.295</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Industrial Health, 1984, Vol.22(4), pp.295-304 |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Administration, Oral Animals Body Weight - drug effects Chemical Phenomena Chemistry Endosulfan Endosulfan - administration & dosage Endosulfan - toxicity Female Fertility Fertility - drug effects Male Male and female rat Oral toxicity Organ Size - drug effects Rats Rats, Inbred Strains Residue |
| title | Response of Rats to Repeated Oral Administration of Endosulfan |
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