Activation of nadph oxidase of human neutrophils. Potentiation of chemotactic peptide by a diacylglycerol

Formyl-methionyl-leucyl-phenylalanine (fMLP) and 1-oleoyl-2-acetyl-glycerol (OAG) are synergistic stimuli of the respiratory burst of neutrophils. Simultaneous exposure to both agents greatly enhanced superoxide production, both in rate and extent. OAG potentiated the response to fMLP also in Ca ++-...

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Veröffentlicht in:	Biochemical and biophysical research communications 1984-11, Vol.125 (1), p.367-373
Hauptverfasser:	Dewald, Beatrice, Payne, Trevor G., Baggiolini, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied sciences Cytochrome c Group - blood Diglycerides - pharmacology Drug Synergism Enzyme Activation Exact sciences and technology Glycerides - pharmacology Humans N-Formylmethionine Leucyl-Phenylalanine - pharmacology NADH, NADPH Oxidoreductases - blood NADPH Oxidases Neutrophils - enzymology Other techniques and industries Protein Kinase C Protein Kinases - blood Superoxides - blood Time Factors
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