Humoral immunity in mice following oral administration of selected pesticides
Five pesticides (carbaryl, DDT, parathion, chlordimeform, and ametryne) were tested for their effects on the immunocompetence of Balb/c mice. All five of the test pesticides were observed to induce statistically significant suppression of the humoral immune response if administered orally, at near l...
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| Veröffentlicht in: | Bulletin of environmental contamination and toxicology 1978-09, Vol.20 (3), p.423-431 |
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| container_title | Bulletin of environmental contamination and toxicology |
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| creator | Wiltrout, R W Ercegovich, C D Ceglowski, W S |
| description | Five pesticides (carbaryl, DDT, parathion, chlordimeform, and ametryne) were tested for their effects on the immunocompetence of Balb/c mice. All five of the test pesticides were observed to induce statistically significant suppression of the humoral immune response if administered orally, at near lethal doses, during an ongoing immune response. Ametryne and chlordimeform were also observed to have a suppressive effect on humoral immune competence if orally administered in a sufficiently large quantity, 1 LD50, at the time of, or prior to, immunization. Administration of 0.1 LD50 parathion per day, over an extended period of time, resulted in a statistically significant suppression of the humoral immune response. |
| doi_str_mv | 10.1007/BF01683542 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0007-4861 |
| ispartof | Bulletin of environmental contamination and toxicology, 1978-09, Vol.20 (3), p.423-431 |
| issn | 0007-4861 1432-0800 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14097105 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Antibody Formation - drug effects Female Lethal Dose 50 Mice Mice, Inbred BALB C Pesticides - pharmacology Pesticides - toxicity |
| title | Humoral immunity in mice following oral administration of selected pesticides |
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