Skin Absorption as a Source of Error in Biological Monitoring
Concentrations of toluene, tetrachloroethylene, and 1,1,1-trichloroethane were determined in blood collected from both forearms of subjects after one of their hands was soaked for 5 min in the corresponding solvent or in a thinner containing toluene, as a simulation of the washing of hands with solv...
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| Veröffentlicht in: | Scandinavian Journal of Work, Environment ＆ Health Environment ＆ Health, 1984-10, Vol.10 (5), p.317-320 |
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| container_end_page | 320 |
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| container_issue | 5 |
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| container_title | Scandinavian Journal of Work, Environment ＆ Health |
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| creator | Aitio, A Pekari, K Järvisalo, J |
| description | Concentrations of toluene, tetrachloroethylene, and 1,1,1-trichloroethane were determined in blood collected from both forearms of subjects after one of their hands was soaked for 5 min in the corresponding solvent or in a thinner containing toluene, as a simulation of the washing of hands with solvent after work. The concentrations of toluene, tetrachloroethylene, and 1,1,1-trichloroethane on the soaked side were high, maximally 5.4, 9.0, and 4.0 μmol/l, respectively, and 20-, 130-, and 35-fold, respectively, compared to the contralateral side. Intraindividual differences were very marked, and dramatic changes were detected within a short period of time. It was not until after 3 h with toluene and 5 h with the chlorinated solvents that the difference between the two arms vanished. It is concluded that analyses of solvents in blood specimens drawn during or immediately after the workday may lead to markedly erroneous estimations of exposure. |
| doi_str_mv | 10.5271/sjweh.2323 |
| format | Article |
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The concentrations of toluene, tetrachloroethylene, and 1,1,1-trichloroethane on the soaked side were high, maximally 5.4, 9.0, and 4.0 μmol/l, respectively, and 20-, 130-, and 35-fold, respectively, compared to the contralateral side. Intraindividual differences were very marked, and dramatic changes were detected within a short period of time. It was not until after 3 h with toluene and 5 h with the chlorinated solvents that the difference between the two arms vanished. It is concluded that analyses of solvents in blood specimens drawn during or immediately after the workday may lead to markedly erroneous estimations of exposure.</description><identifier>ISSN: 0355-3140</identifier><identifier>EISSN: 1795-990X</identifier><identifier>DOI: 10.5271/sjweh.2323</identifier><identifier>PMID: 6523096</identifier><language>eng</language><publisher>Finland: Scandinavian Journal of Work, Environment ＆ Health</publisher><subject>Arm ; Blood ; Chemical hazards ; Environmental assessment ; Environmental Exposure ; Hands ; Humans ; Skin Absorption ; Solvents ; Solvents - blood ; Tetrachloroethylene - blood ; Toluene - blood ; Trichloroethanes - blood ; Volunteerism</subject><ispartof>Scandinavian Journal of Work, Environment ＆ Health, 1984-10, Vol.10 (5), p.317-320</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a502t-ddefe8947ad7c0b51fc45155676a6bf2b714758d88415c90fe96373921247f4e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40965087$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40965087$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6523096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aitio, A</creatorcontrib><creatorcontrib>Pekari, K</creatorcontrib><creatorcontrib>Järvisalo, J</creatorcontrib><title>Skin Absorption as a Source of Error in Biological Monitoring</title><title>Scandinavian Journal of Work, Environment ＆ Health</title><addtitle>Scand J Work Environ Health</addtitle><description>Concentrations of toluene, tetrachloroethylene, and 1,1,1-trichloroethane were determined in blood collected from both forearms of subjects after one of their hands was soaked for 5 min in the corresponding solvent or in a thinner containing toluene, as a simulation of the washing of hands with solvent after work. The concentrations of toluene, tetrachloroethylene, and 1,1,1-trichloroethane on the soaked side were high, maximally 5.4, 9.0, and 4.0 μmol/l, respectively, and 20-, 130-, and 35-fold, respectively, compared to the contralateral side. Intraindividual differences were very marked, and dramatic changes were detected within a short period of time. It was not until after 3 h with toluene and 5 h with the chlorinated solvents that the difference between the two arms vanished. It is concluded that analyses of solvents in blood specimens drawn during or immediately after the workday may lead to markedly erroneous estimations of exposure.</description><subject>Arm</subject><subject>Blood</subject><subject>Chemical hazards</subject><subject>Environmental assessment</subject><subject>Environmental Exposure</subject><subject>Hands</subject><subject>Humans</subject><subject>Skin Absorption</subject><subject>Solvents</subject><subject>Solvents - blood</subject><subject>Tetrachloroethylene - blood</subject><subject>Toluene - blood</subject><subject>Trichloroethanes - blood</subject><subject>Volunteerism</subject><issn>0355-3140</issn><issn>1795-990X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEFLAzEQRoMotVYv3oU9eRC2ZpJNsjl4qKVaQfFQBW8hu5utqdtNTbaI_97UlgqehuF7M8M8hM4BDxkRcB0WX-Z9SCihB6gPQrJUSvx2iPqYMpZSyPAxOglhgTGRcaCHepwRiiXvo5vZh22TURGcX3XWtYkOiU5mbu1Lk7g6mXjvfBKRW-saN7elbpIn19rOedvOT9FRrZtgznZ1gF7vJi_jafr4fP8wHj2mmmHSpVVlapPLTOhKlLhgUJcZA8a44JoXNSkEZILlVZ5nwEqJayM5FVQSIJmoM0MH6HK7d-Xd59qETi1tKE3T6Na4dVDxQwmSQwSvtmDpXQje1Grl7VL7bwVYbVypX1dq4yrCF7ut62Jpqj26k_OXL0J8dx_HW5zhXMR8us219bazahGttVGD2mjfWFcg80grggEDAI_lX0NBKEow_QGpzIDY</recordid><startdate>198410</startdate><enddate>198410</enddate><creator>Aitio, A</creator><creator>Pekari, K</creator><creator>Järvisalo, J</creator><general>Scandinavian Journal of Work, Environment ＆ Health</general><general>National Board of Occupational Safety and Health</general><general>The Working Environment Fund</general><general>Swedish Medical Society, Section for Environmental Health</general><general>Work Research Institutes</general><general>Institute of Occupational Health</general><scope>188</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>198410</creationdate><title>Skin Absorption as a Source of Error in Biological Monitoring</title><author>Aitio, A ; Pekari, K ; Järvisalo, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a502t-ddefe8947ad7c0b51fc45155676a6bf2b714758d88415c90fe96373921247f4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Arm</topic><topic>Blood</topic><topic>Chemical hazards</topic><topic>Environmental assessment</topic><topic>Environmental Exposure</topic><topic>Hands</topic><topic>Humans</topic><topic>Skin Absorption</topic><topic>Solvents</topic><topic>Solvents - blood</topic><topic>Tetrachloroethylene - blood</topic><topic>Toluene - blood</topic><topic>Trichloroethanes - blood</topic><topic>Volunteerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aitio, A</creatorcontrib><creatorcontrib>Pekari, K</creatorcontrib><creatorcontrib>Järvisalo, J</creatorcontrib><collection>Airiti Library</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Scandinavian Journal of Work, Environment ＆ Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aitio, A</au><au>Pekari, K</au><au>Järvisalo, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skin Absorption as a Source of Error in Biological Monitoring</atitle><jtitle>Scandinavian Journal of Work, Environment ＆ Health</jtitle><addtitle>Scand J Work Environ Health</addtitle><date>1984-10</date><risdate>1984</risdate><volume>10</volume><issue>5</issue><spage>317</spage><epage>320</epage><pages>317-320</pages><issn>0355-3140</issn><eissn>1795-990X</eissn><abstract>Concentrations of toluene, tetrachloroethylene, and 1,1,1-trichloroethane were determined in blood collected from both forearms of subjects after one of their hands was soaked for 5 min in the corresponding solvent or in a thinner containing toluene, as a simulation of the washing of hands with solvent after work. 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| identifier | ISSN: 0355-3140 |
| ispartof | Scandinavian Journal of Work, Environment ＆ Health, 1984-10, Vol.10 (5), p.317-320 |
| issn | 0355-3140 1795-990X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14091961 |
| source | Jstor Complete Legacy; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Arm Blood Chemical hazards Environmental assessment Environmental Exposure Hands Humans Skin Absorption Solvents Solvents - blood Tetrachloroethylene - blood Toluene - blood Trichloroethanes - blood Volunteerism |
| title | Skin Absorption as a Source of Error in Biological Monitoring |
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