Decreased NADH-oxidoreductase activities as an early response in rat liver to the carcinogen 2-acetylaminofluorene

Reduced nicotinamide adenine dinucleotide (NADH):ferricyanide reductase and DT-diaphorase specific activity in total homogenates of rat liver are markedly decreased as a very early biochemical event of hepatocarcinogenesis induced by the carcinogen 2-acetylaminofluorene (AAF). A 50 to 75% decrease i...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1985, Vol.45 (1), p.157-163
Hauptverfasser:	SUN, I, MACKELLAR, W. C, CRANE, F. L, BARR, W. L, ELLIOTT, W. L, LEM, N, VARNOLD, R. L, HEINSTEIN, P. F, MORRE, D. J
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Acetylaminofluorene - toxicity Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Kinetics Liver - drug effects Liver - enzymology Liver - pathology Liver Neoplasms - enzymology Liver Neoplasms - pathology Male Medical sciences NAD - analysis NADH, NADPH Oxidoreductases - metabolism Oxidation-Reduction Oxidoreductases - metabolism Precancerous Conditions - enzymology Precancerous Conditions - pathology Rats Rats, Inbred F344 Tumors
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