Perivascular Delivery of Encapsulated Mesenchymal Stem Cells Improves Postischemic Angiogenesis Via Paracrine Activation of VEGF-A

OBJECTIVE—To test the therapeutic activity of perivascular transplantation of encapsulated human mesenchymal stem cells (MSCs) in an immunocompetent mouse model of limb ischemia. APPROACH AND RESULTS—CD1 mice underwent unilateral limb ischemia, followed by randomized treatment with vehicle, alginate...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2013-08, Vol.33 (8), p.1872-1880
Hauptverfasser:	Katare, Rajesh, Riu, Federica, Rowlinson, Jonathan, Lewis, Andrew, Holden, Rachel, Meloni, Marco, Reni, Carlotta, Wallrapp, Christine, Emanueli, Costanza, Madeddu, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Feasibility Studies Female Femoral Artery - physiology Hindlimb - blood supply Humans Ischemia - metabolism Ischemia - physiopathology Ischemia - therapy Laser-Doppler Flowmetry Limb Salvage - methods Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - physiology Mice Neovascularization, Physiologic - physiology Paracrine Communication - physiology Random Allocation Regional Blood Flow - physiology Transplantation, Heterologous Vascular Endothelial Growth Factor A - metabolism
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