Barbiturate potentiation in mercury poisoning
Barbiturate potentiation was observed in Japanese quail fed dietary levels of 4, 21, and 24 ppm Hg as methyl mercuric chloride. Gross symptoms of mercury poisoning were not observed until after BP was observed. After the initial increase in BP time was observed in the birds receiving 4 and 12 ppm me...
Gespeichert in:
| Veröffentlicht in: | Bull. Environ. Contam. Toxicol.; (United States) 1975-06, Vol.13 (6), p.737-740 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 740 |
|---|---|
| container_issue | 6 |
| container_start_page | 737 |
| container_title | Bull. Environ. Contam. Toxicol.; (United States) |
| container_volume | 13 |
| creator | Goldsmith, R.H Soares, J.H. Jr |
| description | Barbiturate potentiation was observed in Japanese quail fed dietary levels of 4, 21, and 24 ppm Hg as methyl mercuric chloride. Gross symptoms of mercury poisoning were not observed until after BP was observed. After the initial increase in BP time was observed in the birds receiving 4 and 12 ppm mercury, there followed a plateau in response until those birds receiving 24 ppm Hg began to show gross symptoms of toxicity and the BP time markedly rose again. Pronounced BP persisted 7 weeks after removal of mercury from the diet reflecting the long biological half-life of mercury as the methyl derivative. Selenium effectively prevented BP after 7 days exposure to toxic levels of methyl mercury chloride. Therefore, results suggest that early toxic effects of mercury can be observed readily by BP and that this environmental contaminant may influence drug activity or increase the sensitivity of the nervous system to sodium pentobarbital. |
| doi_str_mv | 10.1007/BF01721945 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_proquest_miscellaneous_14052320</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>14052320</sourcerecordid><originalsourceid>FETCH-LOGICAL-c364t-de47be4f7cc3aeaf983f713817c7f729434a006727010a3261624c4698a570d73</originalsourceid><addsrcrecordid>eNpFkLFLAzEUh4MotVYXd7E4OAin7yW55G60xapQcNDOIU1zNdImNckN_e89uUKnB-_7-A0fIdcIjwggnyYzQEmx5uUJGSJntIAK4JQMoaMFrwSek4uUfgCwrCgdkAEiq6EUQ1JMdFy63Ead7XgXsvXZ6eyCHzs_3tpo2rjv_i4F7_z6kpw1epPs1eGOyGL28jV9K-Yfr-_T53lhmOC5WFkul5Y30himrW7qijUSWYXSyEbSmjOuAYSkEhA0owIF5YaLutKlhJVkI3LX74aUnUrGZWu-TfDemqy6gbrkvJPue2kXw29rU1Zbl4zdbLS3oU0KOZSUUejEh140MaQUbaN20W113CsE9R9QHQN28s1htV1u7eqo9sU6ftvzRgel19EltfikgAyo5JUUjP0BVrRxNA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14052320</pqid></control><display><type>article</type><title>Barbiturate potentiation in mercury poisoning</title><source>MEDLINE</source><source>SpringerLink_现刊</source><creator>Goldsmith, R.H ; Soares, J.H. Jr</creator><creatorcontrib>Goldsmith, R.H ; Soares, J.H. Jr ; Univ. of Maryland, College Park</creatorcontrib><description>Barbiturate potentiation was observed in Japanese quail fed dietary levels of 4, 21, and 24 ppm Hg as methyl mercuric chloride. Gross symptoms of mercury poisoning were not observed until after BP was observed. After the initial increase in BP time was observed in the birds receiving 4 and 12 ppm mercury, there followed a plateau in response until those birds receiving 24 ppm Hg began to show gross symptoms of toxicity and the BP time markedly rose again. Pronounced BP persisted 7 weeks after removal of mercury from the diet reflecting the long biological half-life of mercury as the methyl derivative. Selenium effectively prevented BP after 7 days exposure to toxic levels of methyl mercury chloride. Therefore, results suggest that early toxic effects of mercury can be observed readily by BP and that this environmental contaminant may influence drug activity or increase the sensitivity of the nervous system to sodium pentobarbital.</description><identifier>ISSN: 0007-4861</identifier><identifier>EISSN: 1432-0800</identifier><identifier>DOI: 10.1007/BF01721945</identifier><identifier>PMID: 1139056</identifier><language>eng</language><publisher>United States</publisher><subject>560300 - Chemicals Metabolism & Toxicology ; ALKYL RADICALS ; ANIMALS ; AZINES ; BARBITURATES ; Barbiturates - pharmacology ; BIOLOGICAL EFFECTS ; BIOLOGICAL HALF-LIFE ; BIRDS ; BODY ; BRAIN ; Brain Chemistry ; CENTRAL NERVOUS SYSTEM ; Drug Synergism ; DRUGS ; ELEMENTS ; HETEROCYCLIC COMPOUNDS ; HYPNOTICS AND SEDATIVES ; INGESTION ; INTAKE ; Liver - metabolism ; Male ; MERCURY ; Mercury - metabolism ; Mercury Poisoning - physiopathology ; METALS ; METHYL RADICALS ; NERVOUS SYSTEM ; ORGANIC COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; ORGANIC OXYGEN COMPOUNDS ; ORGANS ; PYRIMIDINES ; Quail - physiology ; quails ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADICALS ; SELENIUM ; Selenium - poisoning ; SEMIMETALS ; SLEEP ; Sleep - drug effects ; Time Factors ; TOXICITY ; VERTEBRATES</subject><ispartof>Bull. Environ. Contam. Toxicol.; (United States), 1975-06, Vol.13 (6), p.737-740</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-de47be4f7cc3aeaf983f713817c7f729434a006727010a3261624c4698a570d73</citedby><cites>FETCH-LOGICAL-c364t-de47be4f7cc3aeaf983f713817c7f729434a006727010a3261624c4698a570d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1139056$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/7299544$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Goldsmith, R.H</creatorcontrib><creatorcontrib>Soares, J.H. Jr</creatorcontrib><creatorcontrib>Univ. of Maryland, College Park</creatorcontrib><title>Barbiturate potentiation in mercury poisoning</title><title>Bull. Environ. Contam. Toxicol.; (United States)</title><addtitle>Bull Environ Contam Toxicol</addtitle><description>Barbiturate potentiation was observed in Japanese quail fed dietary levels of 4, 21, and 24 ppm Hg as methyl mercuric chloride. Gross symptoms of mercury poisoning were not observed until after BP was observed. After the initial increase in BP time was observed in the birds receiving 4 and 12 ppm mercury, there followed a plateau in response until those birds receiving 24 ppm Hg began to show gross symptoms of toxicity and the BP time markedly rose again. Pronounced BP persisted 7 weeks after removal of mercury from the diet reflecting the long biological half-life of mercury as the methyl derivative. Selenium effectively prevented BP after 7 days exposure to toxic levels of methyl mercury chloride. Therefore, results suggest that early toxic effects of mercury can be observed readily by BP and that this environmental contaminant may influence drug activity or increase the sensitivity of the nervous system to sodium pentobarbital.</description><subject>560300 - Chemicals Metabolism & Toxicology</subject><subject>ALKYL RADICALS</subject><subject>ANIMALS</subject><subject>AZINES</subject><subject>BARBITURATES</subject><subject>Barbiturates - pharmacology</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BIOLOGICAL HALF-LIFE</subject><subject>BIRDS</subject><subject>BODY</subject><subject>BRAIN</subject><subject>Brain Chemistry</subject><subject>CENTRAL NERVOUS SYSTEM</subject><subject>Drug Synergism</subject><subject>DRUGS</subject><subject>ELEMENTS</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HYPNOTICS AND SEDATIVES</subject><subject>INGESTION</subject><subject>INTAKE</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>MERCURY</subject><subject>Mercury - metabolism</subject><subject>Mercury Poisoning - physiopathology</subject><subject>METALS</subject><subject>METHYL RADICALS</subject><subject>NERVOUS SYSTEM</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>ORGANIC OXYGEN COMPOUNDS</subject><subject>ORGANS</subject><subject>PYRIMIDINES</subject><subject>Quail - physiology</subject><subject>quails</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADICALS</subject><subject>SELENIUM</subject><subject>Selenium - poisoning</subject><subject>SEMIMETALS</subject><subject>SLEEP</subject><subject>Sleep - drug effects</subject><subject>Time Factors</subject><subject>TOXICITY</subject><subject>VERTEBRATES</subject><issn>0007-4861</issn><issn>1432-0800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkLFLAzEUh4MotVYXd7E4OAin7yW55G60xapQcNDOIU1zNdImNckN_e89uUKnB-_7-A0fIdcIjwggnyYzQEmx5uUJGSJntIAK4JQMoaMFrwSek4uUfgCwrCgdkAEiq6EUQ1JMdFy63Ead7XgXsvXZ6eyCHzs_3tpo2rjv_i4F7_z6kpw1epPs1eGOyGL28jV9K-Yfr-_T53lhmOC5WFkul5Y30himrW7qijUSWYXSyEbSmjOuAYSkEhA0owIF5YaLutKlhJVkI3LX74aUnUrGZWu-TfDemqy6gbrkvJPue2kXw29rU1Zbl4zdbLS3oU0KOZSUUejEh140MaQUbaN20W113CsE9R9QHQN28s1htV1u7eqo9sU6ftvzRgel19EltfikgAyo5JUUjP0BVrRxNA</recordid><startdate>197506</startdate><enddate>197506</enddate><creator>Goldsmith, R.H</creator><creator>Soares, J.H. Jr</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>OTOTI</scope></search><sort><creationdate>197506</creationdate><title>Barbiturate potentiation in mercury poisoning</title><author>Goldsmith, R.H ; Soares, J.H. Jr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-de47be4f7cc3aeaf983f713817c7f729434a006727010a3261624c4698a570d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>560300 - Chemicals Metabolism & Toxicology</topic><topic>ALKYL RADICALS</topic><topic>ANIMALS</topic><topic>AZINES</topic><topic>BARBITURATES</topic><topic>Barbiturates - pharmacology</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BIOLOGICAL HALF-LIFE</topic><topic>BIRDS</topic><topic>BODY</topic><topic>BRAIN</topic><topic>Brain Chemistry</topic><topic>CENTRAL NERVOUS SYSTEM</topic><topic>Drug Synergism</topic><topic>DRUGS</topic><topic>ELEMENTS</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HYPNOTICS AND SEDATIVES</topic><topic>INGESTION</topic><topic>INTAKE</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>MERCURY</topic><topic>Mercury - metabolism</topic><topic>Mercury Poisoning - physiopathology</topic><topic>METALS</topic><topic>METHYL RADICALS</topic><topic>NERVOUS SYSTEM</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>ORGANIC OXYGEN COMPOUNDS</topic><topic>ORGANS</topic><topic>PYRIMIDINES</topic><topic>Quail - physiology</topic><topic>quails</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADICALS</topic><topic>SELENIUM</topic><topic>Selenium - poisoning</topic><topic>SEMIMETALS</topic><topic>SLEEP</topic><topic>Sleep - drug effects</topic><topic>Time Factors</topic><topic>TOXICITY</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goldsmith, R.H</creatorcontrib><creatorcontrib>Soares, J.H. Jr</creatorcontrib><creatorcontrib>Univ. of Maryland, College Park</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>OSTI.GOV</collection><jtitle>Bull. Environ. Contam. Toxicol.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goldsmith, R.H</au><au>Soares, J.H. Jr</au><aucorp>Univ. of Maryland, College Park</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Barbiturate potentiation in mercury poisoning</atitle><jtitle>Bull. Environ. Contam. Toxicol.; (United States)</jtitle><addtitle>Bull Environ Contam Toxicol</addtitle><date>1975-06</date><risdate>1975</risdate><volume>13</volume><issue>6</issue><spage>737</spage><epage>740</epage><pages>737-740</pages><issn>0007-4861</issn><eissn>1432-0800</eissn><abstract>Barbiturate potentiation was observed in Japanese quail fed dietary levels of 4, 21, and 24 ppm Hg as methyl mercuric chloride. Gross symptoms of mercury poisoning were not observed until after BP was observed. After the initial increase in BP time was observed in the birds receiving 4 and 12 ppm mercury, there followed a plateau in response until those birds receiving 24 ppm Hg began to show gross symptoms of toxicity and the BP time markedly rose again. Pronounced BP persisted 7 weeks after removal of mercury from the diet reflecting the long biological half-life of mercury as the methyl derivative. Selenium effectively prevented BP after 7 days exposure to toxic levels of methyl mercury chloride. Therefore, results suggest that early toxic effects of mercury can be observed readily by BP and that this environmental contaminant may influence drug activity or increase the sensitivity of the nervous system to sodium pentobarbital.</abstract><cop>United States</cop><pmid>1139056</pmid><doi>10.1007/BF01721945</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-4861 |
| ispartof | Bull. Environ. Contam. Toxicol.; (United States), 1975-06, Vol.13 (6), p.737-740 |
| issn | 0007-4861 1432-0800 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14052320 |
| source | MEDLINE; SpringerLink_现刊 |
| subjects | 560300 - Chemicals Metabolism & Toxicology ALKYL RADICALS ANIMALS AZINES BARBITURATES Barbiturates - pharmacology BIOLOGICAL EFFECTS BIOLOGICAL HALF-LIFE BIRDS BODY BRAIN Brain Chemistry CENTRAL NERVOUS SYSTEM Drug Synergism DRUGS ELEMENTS HETEROCYCLIC COMPOUNDS HYPNOTICS AND SEDATIVES INGESTION INTAKE Liver - metabolism Male MERCURY Mercury - metabolism Mercury Poisoning - physiopathology METALS METHYL RADICALS NERVOUS SYSTEM ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC OXYGEN COMPOUNDS ORGANS PYRIMIDINES Quail - physiology quails RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADICALS SELENIUM Selenium - poisoning SEMIMETALS SLEEP Sleep - drug effects Time Factors TOXICITY VERTEBRATES |
| title | Barbiturate potentiation in mercury poisoning |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T05%3A58%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Barbiturate%20potentiation%20in%20mercury%20poisoning&rft.jtitle=Bull.%20Environ.%20Contam.%20Toxicol.;%20(United%20States)&rft.au=Goldsmith,%20R.H&rft.aucorp=Univ.%20of%20Maryland,%20College%20Park&rft.date=1975-06&rft.volume=13&rft.issue=6&rft.spage=737&rft.epage=740&rft.pages=737-740&rft.issn=0007-4861&rft.eissn=1432-0800&rft_id=info:doi/10.1007/BF01721945&rft_dat=%3Cproquest_osti_%3E14052320%3C/proquest_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14052320&rft_id=info:pmid/1139056&rfr_iscdi=true |