Template properties of DNA alkylated with N-methyl- N-nitrosourea and N-ethyl- N-nitrosourea

Alkylation of DNA with N-methyl- N-nitrosourea (MeNU) and N-ethyl- N-itrosourea (EtNU) reduces its ability to support RNA synthesis catalyzed by exogenously added RNA polymerase. It is likely that 7-alkylguanine and alkyl phosphotriester in DNA are mainly responsible for the inhibition of RNA synthe...

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Bibliographische Detailangaben
Veröffentlicht in:	Chemico-biological interactions 1983-09, Vol.46 (2), p.179-188
Hauptverfasser:	Marushige, Keiji, Marushige, Yasuko
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cattle Chemical agents DNA - genetics DNA — Chromatin — RNA synthesis — N-Methyl- N-nitrosourea — N-Ethyl- N-nitrosourea DNA-Directed RNA Polymerases - metabolism Escherichia coli - enzymology Ethylnitrosourea - metabolism Ethylnitrosourea - toxicity Kinetics Medical sciences Methylnitrosourea - metabolism Methylnitrosourea - toxicity Nitrosourea Compounds - toxicity Structure-Activity Relationship Templates, Genetic Thymus Gland - metabolism Transcription, Genetic - drug effects Tumors
Online-Zugang:	Volltext
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