L-pyroglutamate: An alternate neurotoxin for a rodent model of Huntington's disease
Intrastriatal injections of L-Pyroglutamate (L-PGA) in mice produced behavioral and neuropathological effects that resemble in part the kainate-injected rat striatal model of Huntington's Disease (HD). The behavioral responses induced after unilateral injections of L-PGA included circling, post...
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| Veröffentlicht in: | Brain research bulletin 1984-01, Vol.13 (3), p.443-456 |
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| creator | Rieke, Garl K. Scarfe, A.David Hunter, Jon F. |
| description | Intrastriatal injections of L-Pyroglutamate (L-PGA) in mice produced behavioral and neuropathological effects that resemble in part the kainate-injected rat striatal model of Huntington's Disease (HD). The behavioral responses induced after unilateral injections of L-PGA included circling, postural asymmetry of head and trunk and possible dyskinesias. The neuropil in the injected striatum contained dilated profiles, degenerating neurons and oligodendroglia, and numerous phagocytic microglial-like cells. A dose response relation existed. The size of the lesion (expressed as a percent volume of the striatum destroyed) ranged from 1±0.18% at 0.02 μmoles to 20.2±3.97% at 200 μmoles L-PGA (pH=7.3). L-PGA is a weak neurotoxin when compared to kainic acid. Several factors raise interest in the possible role of L-PGA in HD, including the recently reported elevated plasma levels of L-PGA in some HD patients [51,52], and these are considered in the discussion. |
| doi_str_mv | 10.1016/0361-9230(84)90096-0 |
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The behavioral responses induced after unilateral injections of L-PGA included circling, postural asymmetry of head and trunk and possible dyskinesias. The neuropil in the injected striatum contained dilated profiles, degenerating neurons and oligodendroglia, and numerous phagocytic microglial-like cells. A dose response relation existed. The size of the lesion (expressed as a percent volume of the striatum destroyed) ranged from 1±0.18% at 0.02 μmoles to 20.2±3.97% at 200 μmoles L-PGA (pH=7.3). L-PGA is a weak neurotoxin when compared to kainic acid. Several factors raise interest in the possible role of L-PGA in HD, including the recently reported elevated plasma levels of L-PGA in some HD patients [51,52], and these are considered in the discussion.</description><identifier>ISSN: 0361-9230</identifier><identifier>EISSN: 1873-2747</identifier><identifier>DOI: 10.1016/0361-9230(84)90096-0</identifier><identifier>PMID: 6238648</identifier><identifier>CODEN: BRBUDU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animal model of Huntington's disease ; Animals ; Basal ganglia ; Basal Ganglia - pathology ; Basal Ganglia Diseases - chemically induced ; Basal Ganglia Diseases - pathology ; Biological and medical sciences ; Caudatoputamen ; Corpus Striatum - drug effects ; Disease Models, Animal ; Huntington Disease - chemically induced ; Huntington Disease - pathology ; Kainic Acid ; L-Pyroglutamic acid ; Male ; Medical sciences ; Mice ; Microscopy, Electron ; Movement disorders ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Neurotoxic hypothesis of Huntington's disease ; Neurotoxin ; Pyrrolidinones - toxicity ; Pyrrolidonecarboxylic Acid - toxicity</subject><ispartof>Brain research bulletin, 1984-01, Vol.13 (3), p.443-456</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-7224ff98b534169afda398c608c96fa5ce2cb06887e102b421e3fa212ae932893</citedby><cites>FETCH-LOGICAL-c417t-7224ff98b534169afda398c608c96fa5ce2cb06887e102b421e3fa212ae932893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0361-9230(84)90096-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8924916$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6238648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rieke, Garl K.</creatorcontrib><creatorcontrib>Scarfe, A.David</creatorcontrib><creatorcontrib>Hunter, Jon F.</creatorcontrib><title>L-pyroglutamate: An alternate neurotoxin for a rodent model of Huntington's disease</title><title>Brain research bulletin</title><addtitle>Brain Res Bull</addtitle><description>Intrastriatal injections of L-Pyroglutamate (L-PGA) in mice produced behavioral and neuropathological effects that resemble in part the kainate-injected rat striatal model of Huntington's Disease (HD). The behavioral responses induced after unilateral injections of L-PGA included circling, postural asymmetry of head and trunk and possible dyskinesias. The neuropil in the injected striatum contained dilated profiles, degenerating neurons and oligodendroglia, and numerous phagocytic microglial-like cells. A dose response relation existed. The size of the lesion (expressed as a percent volume of the striatum destroyed) ranged from 1±0.18% at 0.02 μmoles to 20.2±3.97% at 200 μmoles L-PGA (pH=7.3). L-PGA is a weak neurotoxin when compared to kainic acid. Several factors raise interest in the possible role of L-PGA in HD, including the recently reported elevated plasma levels of L-PGA in some HD patients [51,52], and these are considered in the discussion.</description><subject>Animal model of Huntington's disease</subject><subject>Animals</subject><subject>Basal ganglia</subject><subject>Basal Ganglia - pathology</subject><subject>Basal Ganglia Diseases - chemically induced</subject><subject>Basal Ganglia Diseases - pathology</subject><subject>Biological and medical sciences</subject><subject>Caudatoputamen</subject><subject>Corpus Striatum - drug effects</subject><subject>Disease Models, Animal</subject><subject>Huntington Disease - chemically induced</subject><subject>Huntington Disease - pathology</subject><subject>Kainic Acid</subject><subject>L-Pyroglutamic acid</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microscopy, Electron</subject><subject>Movement disorders</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Neurotoxic hypothesis of Huntington's disease</subject><subject>Neurotoxin</subject><subject>Pyrrolidinones - toxicity</subject><subject>Pyrrolidonecarboxylic Acid - toxicity</subject><issn>0361-9230</issn><issn>1873-2747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVJSBy3_6AFHULbHLbVl7VSDoUQmg8w5ND2LGTtKCjsSo6kDfG_7zo2PuY0zMwzw8uD0GdKflBC5U_CJW004-S7EheaEC0b8gHNqGp5w1rRHqHZATlFZ6U8EUKkWsgTdCIZV1KoGfqzbNabnB77sdrBVrjEVxHbvkKOU4cjjDnV9Boi9ilji3PqIFY8TKXHyeO7MdYQH2uK3wruQgFb4CM69rYv8Glf5-jfze-_13fN8uH2_vpq2ThB29q0jAnvtVotuKBSW99ZrpWTRDktvV04YG41BVYtUMJWglHg3jLKLGjOlOZz9HX3d53T8wilmiEUB31vI6SxGCoIoy1rJ1DsQJdTKRm8Wecw2LwxlJitS7MVZbaijBLmzeU0mqMv-__jaoDucLSXN-3P93tbnO19ttGFcsCUZkJTOWG_dhhMLl4CZFNcgOigCxlcNV0K7-f4D7kfj1Q</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Rieke, Garl K.</creator><creator>Scarfe, A.David</creator><creator>Hunter, Jon F.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19840101</creationdate><title>L-pyroglutamate: An alternate neurotoxin for a rodent model of Huntington's disease</title><author>Rieke, Garl K. ; Scarfe, A.David ; Hunter, Jon F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-7224ff98b534169afda398c608c96fa5ce2cb06887e102b421e3fa212ae932893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animal model of Huntington's disease</topic><topic>Animals</topic><topic>Basal ganglia</topic><topic>Basal Ganglia - pathology</topic><topic>Basal Ganglia Diseases - chemically induced</topic><topic>Basal Ganglia Diseases - pathology</topic><topic>Biological and medical sciences</topic><topic>Caudatoputamen</topic><topic>Corpus Striatum - drug effects</topic><topic>Disease Models, Animal</topic><topic>Huntington Disease - chemically induced</topic><topic>Huntington Disease - pathology</topic><topic>Kainic Acid</topic><topic>L-Pyroglutamic acid</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microscopy, Electron</topic><topic>Movement disorders</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Neurotoxic hypothesis of Huntington's disease</topic><topic>Neurotoxin</topic><topic>Pyrrolidinones - toxicity</topic><topic>Pyrrolidonecarboxylic Acid - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rieke, Garl K.</creatorcontrib><creatorcontrib>Scarfe, A.David</creatorcontrib><creatorcontrib>Hunter, Jon F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rieke, Garl K.</au><au>Scarfe, A.David</au><au>Hunter, Jon F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>L-pyroglutamate: An alternate neurotoxin for a rodent model of Huntington's disease</atitle><jtitle>Brain research bulletin</jtitle><addtitle>Brain Res Bull</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>13</volume><issue>3</issue><spage>443</spage><epage>456</epage><pages>443-456</pages><issn>0361-9230</issn><eissn>1873-2747</eissn><coden>BRBUDU</coden><abstract>Intrastriatal injections of L-Pyroglutamate (L-PGA) in mice produced behavioral and neuropathological effects that resemble in part the kainate-injected rat striatal model of Huntington's Disease (HD). The behavioral responses induced after unilateral injections of L-PGA included circling, postural asymmetry of head and trunk and possible dyskinesias. The neuropil in the injected striatum contained dilated profiles, degenerating neurons and oligodendroglia, and numerous phagocytic microglial-like cells. A dose response relation existed. The size of the lesion (expressed as a percent volume of the striatum destroyed) ranged from 1±0.18% at 0.02 μmoles to 20.2±3.97% at 200 μmoles L-PGA (pH=7.3). L-PGA is a weak neurotoxin when compared to kainic acid. Several factors raise interest in the possible role of L-PGA in HD, including the recently reported elevated plasma levels of L-PGA in some HD patients [51,52], and these are considered in the discussion.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6238648</pmid><doi>10.1016/0361-9230(84)90096-0</doi><tpages>14</tpages></addata></record> |
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| subjects | Animal model of Huntington's disease Animals Basal ganglia Basal Ganglia - pathology Basal Ganglia Diseases - chemically induced Basal Ganglia Diseases - pathology Biological and medical sciences Caudatoputamen Corpus Striatum - drug effects Disease Models, Animal Huntington Disease - chemically induced Huntington Disease - pathology Kainic Acid L-Pyroglutamic acid Male Medical sciences Mice Microscopy, Electron Movement disorders Nervous system involvement in other diseases. Miscellaneous Neurology Neurotoxic hypothesis of Huntington's disease Neurotoxin Pyrrolidinones - toxicity Pyrrolidonecarboxylic Acid - toxicity |
| title | L-pyroglutamate: An alternate neurotoxin for a rodent model of Huntington's disease |
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