Many faces of mitochondrial uncoupling during age: damage or defense?

An increased mitochondrial proton leak occurs in aging, but the origin of such modification remains unclear. This study defined the cause of mitochondrial uncoupling in mitotic (liver) and postmitotic (heart) rat tissues during aging and its effects on energy homeostasis and free radical production....

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Veröffentlicht in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2013-08, Vol.68 (8), p.892-902
Hauptverfasser:	Bellanti, Francesco, Romano, Antonino Davide, Giudetti, Anna Maria, Rollo, Tiziana, Blonda, Maria, Tamborra, Rosanna, Vendemiale, Gianluigi, Serviddio, Gaetano
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Nucleotide Translocator 1 - genetics Adenine Nucleotide Translocator 1 - metabolism Adenine Nucleotide Translocator 2 - genetics Adenine Nucleotide Translocator 2 - metabolism Adenosine Triphosphate - metabolism Aging Aging - genetics Aging - metabolism Animals Biosynthesis Energy Metabolism Fatty Acids - metabolism Free radicals Free Radicals - metabolism Glycolysis Homeostasis Ion Channels - genetics Ion Channels - metabolism Male Membrane Potential, Mitochondrial Mitochondria, Heart - metabolism Mitochondria, Liver - metabolism Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Oxidative Stress Proteins Protons Rats Rats, Wistar RNA, Messenger - genetics RNA, Messenger - metabolism Studies Uncoupling Protein 2 Uncoupling Protein 3
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