Stereoselective syntheses of functionalized spirocyclopenteneoxindoles via triphenylphosphine-catalyzed [3+2] cycloaddition reactions
Spirocyclopenteneoxindole derivatives were obtained by stereoselective triphenylphosphine-catalyzed [3+2] cycloadditions of ynones and alkylidene oxindole derivatives. This approach is based on the Michael addition of ynones to alkylidene oxindole derivatives, followed by intermolecular α -addition...
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| Veröffentlicht in: | Molecular diversity 2013-08, Vol.17 (3), p.563-571 |
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| container_title | Molecular diversity |
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| creator | Zhou, Qing-Fa Chu, Xue-Ping Ge, Fei-Fei Li, Cheng Lu, Tao |
| description | Spirocyclopenteneoxindole derivatives were obtained by stereoselective triphenylphosphine-catalyzed [3+2] cycloadditions of ynones and alkylidene oxindole derivatives. This approach is based on the Michael addition of ynones to alkylidene oxindole derivatives, followed by intermolecular
α
-addition using 50 mol% triphenylphosphine as catalyst.
Graphical Abstract |
| doi_str_mv | 10.1007/s11030-013-9456-8 |
| format | Article |
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α
-addition using 50 mol% triphenylphosphine as catalyst.
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α
-addition using 50 mol% triphenylphosphine as catalyst.
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This approach is based on the Michael addition of ynones to alkylidene oxindole derivatives, followed by intermolecular
α
-addition using 50 mol% triphenylphosphine as catalyst.
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| subjects | Biochemistry Biomedical and Life Sciences Catalysis Cycloaddition Reaction Cyclopentanes - chemical synthesis Drug Design Full-Length Paper Indoles - chemical synthesis Indoles - chemistry Life Sciences Organic Chemistry Organophosphorus Compounds - chemistry Pharmacy Polymer Sciences Spiro Compounds - chemical synthesis Stereoisomerism |
| title | Stereoselective syntheses of functionalized spirocyclopenteneoxindoles via triphenylphosphine-catalyzed [3+2] cycloaddition reactions |
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