High expression of JMJD6 predicts unfavorable survival in lung adenocarcinoma
The upregulated expression of JMJD6 was observed in various human cancers. However, little was known about JMJD6 expression and its clinicopathological significance in lung adenocarcinoma. The aim of this study was to investigate the expression and significance of JMJD6 in lung adenocarcinoma progre...
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| Veröffentlicht in: | Tumor biology 2013-08, Vol.34 (4), p.2397-2401 |
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| creator | Zhang, Ji Ni, Shuang-Shuang Zhao, Wei-Li Dong, Xiao-Chun Wang, Jin-Lin |
| description | The upregulated expression of JMJD6 was observed in various human cancers. However, little was known about JMJD6 expression and its clinicopathological significance in lung adenocarcinoma. The aim of this study was to investigate the expression and significance of JMJD6 in lung adenocarcinoma progression and prognosis. The levels of JMJD6 mRNA and protein in lung adenocarcinoma specimens and corresponding non-tumorous lung tissues were evaluated by quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) and Western blot. In order to investigate the correlations between JMJD6 and the clinicopathological features of lung adenocarcinoma, the expression of JMJD6 in 154 patients with lung adenocarcinoma was detected by immunohistochemistry. By qRT-PCR and Western blot, the relative expression levels of JMJD6 mRNA and protein were significantly higher in lung adenocarcinoma tissues than in corresponding non-tumorous lung tissues (
P
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| doi_str_mv | 10.1007/s13277-013-0789-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1401092152</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3020911591</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-a2589b86d195e52699191400a1b91ad1d3af197e508f8d9f840fa0f260f5426c3</originalsourceid><addsrcrecordid>eNp1kD1PwzAQhi0EoqXwA1iQJRaWwJ0TJ_GIykepWrHAbLmJXVKldrGbCv49rloQQmLy2ffce9ZDyDnCNQIUNwFTVhQJYJpAUYpEHJA-Zize0hIOYw0IScbKtEdOQlgAIBciPyY9lnLBGcM-mY6a-RvVHyuvQ2icpc7Q8XR8l9P4UjfVOtDOGrVxXs1aTUPnN81GtbSxtO3snKpaW1cpXzXWLdUpOTKqDfpsfw7I68P9y3CUTJ4fn4a3k6RKC7ZOFOOlmJV5jYJrznIhUGAGoHAmUNVYp8qgKDSH0pS1MGUGRoFhORiesbxKB-Rql7vy7r3TYS2XTah02yqrXRdkDEMQDDmL6OUfdOE6b-PvtlQUlTHMIoU7qvIuBK-NXPlmqfynRJBb13LnWkbXcutaijhzsU_uZktd_0x8y40A2wEhtuxc-1-r_039Aq6Ih6I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1400384214</pqid></control><display><type>article</type><title>High expression of JMJD6 predicts unfavorable survival in lung adenocarcinoma</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Zhang, Ji ; Ni, Shuang-Shuang ; Zhao, Wei-Li ; Dong, Xiao-Chun ; Wang, Jin-Lin</creator><creatorcontrib>Zhang, Ji ; Ni, Shuang-Shuang ; Zhao, Wei-Li ; Dong, Xiao-Chun ; Wang, Jin-Lin</creatorcontrib><description>The upregulated expression of JMJD6 was observed in various human cancers. However, little was known about JMJD6 expression and its clinicopathological significance in lung adenocarcinoma. The aim of this study was to investigate the expression and significance of JMJD6 in lung adenocarcinoma progression and prognosis. The levels of JMJD6 mRNA and protein in lung adenocarcinoma specimens and corresponding non-tumorous lung tissues were evaluated by quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) and Western blot. In order to investigate the correlations between JMJD6 and the clinicopathological features of lung adenocarcinoma, the expression of JMJD6 in 154 patients with lung adenocarcinoma was detected by immunohistochemistry. By qRT-PCR and Western blot, the relative expression levels of JMJD6 mRNA and protein were significantly higher in lung adenocarcinoma tissues than in corresponding non-tumorous lung tissues (
P
< 0.001). Immunohistochemical staining revealed that high JMJD6 expression was closely correlated with tumor size (
P
= 0.005), pathological grade (
P
= 0.003), pT status (
P
= 0.012), pN status (
P
= 0.003), and pleural invasion (
P
< 0.001). Moreover, the results of Kaplan–Meier analysis indicated that a high expression level of JMJD6 resulted in a significantly poor prognosis of lung adenocarcinoma patients. Multivariate analysis showed that the status of JMJD6 expression was an independent prognostic factor for lung adenocarcinoma patients. Our results showed that JMJD6 plays a key role in lung adenocarcinoma and therefore may provide an opportunity for developing a novel therapeutic target as well as a prognostic marker in lung adenocarcinoma.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-013-0789-9</identifier><identifier>PMID: 23595221</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - metabolism ; Adenocarcinoma - mortality ; Adenocarcinoma of Lung ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Disease Progression ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic ; Genetic Association Studies ; Humans ; Jumonji Domain-Containing Histone Demethylases - genetics ; Jumonji Domain-Containing Histone Demethylases - metabolism ; Lung cancer ; Lung Neoplasms - genetics ; Lung Neoplasms - metabolism ; Lung Neoplasms - mortality ; Male ; Medical prognosis ; Middle Aged ; Prognosis ; Research Article ; RNA, Messenger - metabolism</subject><ispartof>Tumor biology, 2013-08, Vol.34 (4), p.2397-2401</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-a2589b86d195e52699191400a1b91ad1d3af197e508f8d9f840fa0f260f5426c3</citedby><cites>FETCH-LOGICAL-c372t-a2589b86d195e52699191400a1b91ad1d3af197e508f8d9f840fa0f260f5426c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13277-013-0789-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13277-013-0789-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23595221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Ji</creatorcontrib><creatorcontrib>Ni, Shuang-Shuang</creatorcontrib><creatorcontrib>Zhao, Wei-Li</creatorcontrib><creatorcontrib>Dong, Xiao-Chun</creatorcontrib><creatorcontrib>Wang, Jin-Lin</creatorcontrib><title>High expression of JMJD6 predicts unfavorable survival in lung adenocarcinoma</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><addtitle>Tumour Biol</addtitle><description>The upregulated expression of JMJD6 was observed in various human cancers. However, little was known about JMJD6 expression and its clinicopathological significance in lung adenocarcinoma. The aim of this study was to investigate the expression and significance of JMJD6 in lung adenocarcinoma progression and prognosis. The levels of JMJD6 mRNA and protein in lung adenocarcinoma specimens and corresponding non-tumorous lung tissues were evaluated by quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) and Western blot. In order to investigate the correlations between JMJD6 and the clinicopathological features of lung adenocarcinoma, the expression of JMJD6 in 154 patients with lung adenocarcinoma was detected by immunohistochemistry. By qRT-PCR and Western blot, the relative expression levels of JMJD6 mRNA and protein were significantly higher in lung adenocarcinoma tissues than in corresponding non-tumorous lung tissues (
P
< 0.001). Immunohistochemical staining revealed that high JMJD6 expression was closely correlated with tumor size (
P
= 0.005), pathological grade (
P
= 0.003), pT status (
P
= 0.012), pN status (
P
= 0.003), and pleural invasion (
P
< 0.001). Moreover, the results of Kaplan–Meier analysis indicated that a high expression level of JMJD6 resulted in a significantly poor prognosis of lung adenocarcinoma patients. Multivariate analysis showed that the status of JMJD6 expression was an independent prognostic factor for lung adenocarcinoma patients. Our results showed that JMJD6 plays a key role in lung adenocarcinoma and therefore may provide an opportunity for developing a novel therapeutic target as well as a prognostic marker in lung adenocarcinoma.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma of Lung</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genetic Association Studies</subject><subject>Humans</subject><subject>Jumonji Domain-Containing Histone Demethylases - genetics</subject><subject>Jumonji Domain-Containing Histone Demethylases - metabolism</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - mortality</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Research Article</subject><subject>RNA, Messenger - metabolism</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kD1PwzAQhi0EoqXwA1iQJRaWwJ0TJ_GIykepWrHAbLmJXVKldrGbCv49rloQQmLy2ffce9ZDyDnCNQIUNwFTVhQJYJpAUYpEHJA-Zize0hIOYw0IScbKtEdOQlgAIBciPyY9lnLBGcM-mY6a-RvVHyuvQ2icpc7Q8XR8l9P4UjfVOtDOGrVxXs1aTUPnN81GtbSxtO3snKpaW1cpXzXWLdUpOTKqDfpsfw7I68P9y3CUTJ4fn4a3k6RKC7ZOFOOlmJV5jYJrznIhUGAGoHAmUNVYp8qgKDSH0pS1MGUGRoFhORiesbxKB-Rql7vy7r3TYS2XTah02yqrXRdkDEMQDDmL6OUfdOE6b-PvtlQUlTHMIoU7qvIuBK-NXPlmqfynRJBb13LnWkbXcutaijhzsU_uZktd_0x8y40A2wEhtuxc-1-r_039Aq6Ih6I</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>Zhang, Ji</creator><creator>Ni, Shuang-Shuang</creator><creator>Zhao, Wei-Li</creator><creator>Dong, Xiao-Chun</creator><creator>Wang, Jin-Lin</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20130801</creationdate><title>High expression of JMJD6 predicts unfavorable survival in lung adenocarcinoma</title><author>Zhang, Ji ; Ni, Shuang-Shuang ; Zhao, Wei-Li ; Dong, Xiao-Chun ; Wang, Jin-Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-a2589b86d195e52699191400a1b91ad1d3af197e508f8d9f840fa0f260f5426c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma of Lung</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genetic Association Studies</topic><topic>Humans</topic><topic>Jumonji Domain-Containing Histone Demethylases - genetics</topic><topic>Jumonji Domain-Containing Histone Demethylases - metabolism</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - mortality</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Research Article</topic><topic>RNA, Messenger - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Ji</creatorcontrib><creatorcontrib>Ni, Shuang-Shuang</creatorcontrib><creatorcontrib>Zhao, Wei-Li</creatorcontrib><creatorcontrib>Dong, Xiao-Chun</creatorcontrib><creatorcontrib>Wang, Jin-Lin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Research Library</collection><collection>ProQuest Biological Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Ji</au><au>Ni, Shuang-Shuang</au><au>Zhao, Wei-Li</au><au>Dong, Xiao-Chun</au><au>Wang, Jin-Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High expression of JMJD6 predicts unfavorable survival in lung adenocarcinoma</atitle><jtitle>Tumor biology</jtitle><stitle>Tumor Biol</stitle><addtitle>Tumour Biol</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>34</volume><issue>4</issue><spage>2397</spage><epage>2401</epage><pages>2397-2401</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract>The upregulated expression of JMJD6 was observed in various human cancers. However, little was known about JMJD6 expression and its clinicopathological significance in lung adenocarcinoma. The aim of this study was to investigate the expression and significance of JMJD6 in lung adenocarcinoma progression and prognosis. The levels of JMJD6 mRNA and protein in lung adenocarcinoma specimens and corresponding non-tumorous lung tissues were evaluated by quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) and Western blot. In order to investigate the correlations between JMJD6 and the clinicopathological features of lung adenocarcinoma, the expression of JMJD6 in 154 patients with lung adenocarcinoma was detected by immunohistochemistry. By qRT-PCR and Western blot, the relative expression levels of JMJD6 mRNA and protein were significantly higher in lung adenocarcinoma tissues than in corresponding non-tumorous lung tissues (
P
< 0.001). Immunohistochemical staining revealed that high JMJD6 expression was closely correlated with tumor size (
P
= 0.005), pathological grade (
P
= 0.003), pT status (
P
= 0.012), pN status (
P
= 0.003), and pleural invasion (
P
< 0.001). Moreover, the results of Kaplan–Meier analysis indicated that a high expression level of JMJD6 resulted in a significantly poor prognosis of lung adenocarcinoma patients. Multivariate analysis showed that the status of JMJD6 expression was an independent prognostic factor for lung adenocarcinoma patients. Our results showed that JMJD6 plays a key role in lung adenocarcinoma and therefore may provide an opportunity for developing a novel therapeutic target as well as a prognostic marker in lung adenocarcinoma.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>23595221</pmid><doi>10.1007/s13277-013-0789-9</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Tumor biology, 2013-08, Vol.34 (4), p.2397-2401 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma of Lung Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Cancer Research Disease Progression Female Gene expression Gene Expression Regulation, Neoplastic Genetic Association Studies Humans Jumonji Domain-Containing Histone Demethylases - genetics Jumonji Domain-Containing Histone Demethylases - metabolism Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - mortality Male Medical prognosis Middle Aged Prognosis Research Article RNA, Messenger - metabolism |
| title | High expression of JMJD6 predicts unfavorable survival in lung adenocarcinoma |
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