In vitro metabolism and bioavailability tests for endocrine active substances: what is needed next for regulatory purposes?

Legislation and prospective legislative proposals internationally (may) require that chemicals be tested for their ability to disrupt the hormonal systems of mammals. Chemicals found to test positive in vitro are considered to be endocrine active substances (EAS) and may be putative endocrine disrup...

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Veröffentlicht in:	ALTEX, alternatives to animal experimentation alternatives to animal experimentation, 2013, Vol.30 (3), p.331-351
Hauptverfasser:	Jacobs, Miriam N, Laws, Susan C, Willett, Kate, Schmieder, Pat, Odum, Jenny, Bovee, Toine F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Testing Alternatives Animals Biological Availability Endocrine Disruptors - metabolism Endocrine Disruptors - pharmacokinetics Environmental Pollutants - toxicity Environmental Pollution - legislation & jurisprudence Humans International Cooperation Toxicity Tests
Online-Zugang:	Volltext
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