Integration of High-Resolution Methylome and Transcriptome Analyses to Dissect Epigenomic Changes in Childhood Acute Lymphoblastic Leukemia

B-cell precursor acute lymphoblastic leukemia (pre-B ALL) is the most common pediatric cancer. Although the genetic determinants underlying disease onset remain unclear, epigenetic modifications including DNA methylation are suggested to contribute significantly to leukemogenesis. Using the Illumina...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2013-07, Vol.73 (14), p.4323-4336
Hauptverfasser:	BUSCHE, Stephan, BING GE, PASTINEN, Tomi, VIDAL, Ramon, SPINELLA, Jean-François, SAILLOUR, Virginie, RICHER, Chantal, HEALY, Jasmine, CHEN, Shu-Huang, DROIT, Arnaud, SINNETT, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antineoplastic agents Biological and medical sciences Child Child, Preschool Core Binding Factor Alpha 2 Subunit - genetics CpG Islands DNA Methylation Epigenesis, Genetic Epigenomics - methods ETS Translocation Variant 6 Protein Female Gene Expression Gene Expression Profiling - methods Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences MicroRNAs - genetics Pharmacology. Drug treatments Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Proto-Oncogene Proteins c-ets - genetics Repressor Proteins - genetics Transcription Initiation Site Transcriptome Tumors
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