PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancer

Phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway activation is often associated with altered expression or mutations of PIK3CA, TP53/p73, PTEN, and TGF-β receptors (TGFBR) in head and neck squamous cell carcinomas (HNSCC). However, little is known about how these alterat...

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Veröffentlicht in:	Clinical cancer research 2013-07, Vol.19 (14), p.3808-3819
Hauptverfasser:	Herzog, Amanda, Bian, Yansong, Vander Broek, Robert, Hall, Bradford, Coupar, Jamie, Cheng, Hui, Sowers, Anastasia L, Cook, John D, Mitchell, James B, Chen, Zhong, Kulkarni, Ashok B, Van Waes, Carter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Benzothiazoles - pharmacology Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Combined Modality Therapy Female Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Head and Neck Neoplasms - therapy Humans Mice Mice, Inbred BALB C Mice, Knockout Mice, Nude Mice, SCID Phosphatidylinositol 3-Kinases - metabolism Phosphoinositide-3 Kinase Inhibitors Pyridones - pharmacology Pyrimidines - pharmacology Signal Transduction Toluene - analogs & derivatives Toluene - pharmacology TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Transcriptional Activation Tumor Burden - drug effects Tumor Suppressor Protein p53 - antagonists & inhibitors Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Xenograft Model Antitumor Assays
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