Oxidative stress response elicited by mitochondrial dysfunction: Implication in the pathophysiology of aging

Under normal physiological conditions, reactive oxygen species (ROS) serve as ‘redox messengers’ in the regulation of intracellular signalling, whereas excess ROS may induce irreversible damage to cellular components and lead to cell death by promoting the intrinsic apoptotic pathway through mitocho...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2013-05, Vol.238 (5), p.450-460
Hauptverfasser:	Wang, Chih-Hao, Wu, Shi-Bei, Wu, Yu-Ting, Wei, Yau-Huei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Autophagy - genetics DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Humans Longevity Mitochondria - genetics Mitochondria - metabolism Mitochondria - pathology Mitochondrial Degradation - genetics Mutation Oxidative Stress Protein Processing, Post-Translational Reactive Oxygen Species - metabolism
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