Non-invasively measured aortic wave reflection and pulse pressure amplification are related to the severity of coronary artery disease
Abstract Background Augmentation index (AIx) and pulse pressure amplification (PPA, here the aortic/brachial pulse pressure ratio) are an age-related emerging risk factor for cardiovascular disease. However, it has not been clearly shown that AIx and PPA predict a high risk of coronary artery diseas...
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| Veröffentlicht in: | Journal of cardiology 2013-08, Vol.62 (2), p.131-137 |
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| creator | Cho, Sung Woo, MD Kim, Byung Kyu, MD Kim, Jeong Hoon, MD Byun, Young Sup, MD Goh, Choong Won, MD Rhee, Kun Joo, MD Ahn, Hyo Seung, MD Lee, Byoung Kwon, MD Kim, Byung Ok, MD |
| description | Abstract Background Augmentation index (AIx) and pulse pressure amplification (PPA, here the aortic/brachial pulse pressure ratio) are an age-related emerging risk factor for cardiovascular disease. However, it has not been clearly shown that AIx and PPA predict a high risk of coronary artery disease (CAD). Objectives The aim of the study was to investigate the association between non-invasively measured aortic wave reflection (AWR) and PPA and CAD. Methods The study group consisted of 80 patients who were admitted to our institute for elective coronary angiography. We non-invasively measured augmentation pressure (AP), AIx, and PPA using radial applanation tonometry. Results When the extent of CAD was divided by no or minimal CAD, 1- or 2- and 3-vessel disease (VD), there was a significant association between the extent of CAD and AIx and PPA in patients aged |
| doi_str_mv | 10.1016/j.jjcc.2013.03.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1400401011</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S091450871300124X</els_id><sourcerecordid>1400401011</sourcerecordid><originalsourceid>FETCH-LOGICAL-c545t-1cd6a29d2c1b0747e20422320458684125cc6a030f40c7c58c084d29cec1474d3</originalsourceid><addsrcrecordid>eNp9ksuKFTEQhoMoznH0BVxIlm76WEmnbyCCDN5g0IUK7kKmUo1puzttku7hvIDPbZozunAhFKnNV3-Sj2LsqYCjAFG_GI7DgHiUIMoj5BLqHjuItqkL1ZTtfXaATqiigra5YI9iHABq6Nr6IbuQZVOKTlYH9uujnws3bya6jcYTn8jENZDlxofkkN-ajXigfiRMzs_czJYv6xiJL4HijnIzLaPrHZozEHZ-NClnJM_Td-KRNgounbjvOfrgZxNOmUuUm3Ux30iP2YPe5NQnd_2SfX375svV--L607sPV6-vC6xUlQqBtjaysxLFDTSqIQlKyjKfVVu3SsgKsTZQQq8AG6xahFZZ2SGhUI2y5SV7fs5dgv-5Ukx6chFpHM1Mfo1aKAAF2a7IqDyjGHyMWYFegpvy07UAvfvXg979692_hlxC5aFnd_nrzUT278gf4Rl4eQYo_3JzFHRERzOSdSEr1ta7_-e_-mccRzdn9-MPOlEc_Brm7E8LHaUG_XnfgH0BRAkgpPpW_ga9Ta16</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1400401011</pqid></control><display><type>article</type><title>Non-invasively measured aortic wave reflection and pulse pressure amplification are related to the severity of coronary artery disease</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Cho, Sung Woo, MD ; Kim, Byung Kyu, MD ; Kim, Jeong Hoon, MD ; Byun, Young Sup, MD ; Goh, Choong Won, MD ; Rhee, Kun Joo, MD ; Ahn, Hyo Seung, MD ; Lee, Byoung Kwon, MD ; Kim, Byung Ok, MD</creator><creatorcontrib>Cho, Sung Woo, MD ; Kim, Byung Kyu, MD ; Kim, Jeong Hoon, MD ; Byun, Young Sup, MD ; Goh, Choong Won, MD ; Rhee, Kun Joo, MD ; Ahn, Hyo Seung, MD ; Lee, Byoung Kwon, MD ; Kim, Byung Ok, MD</creatorcontrib><description>Abstract Background Augmentation index (AIx) and pulse pressure amplification (PPA, here the aortic/brachial pulse pressure ratio) are an age-related emerging risk factor for cardiovascular disease. However, it has not been clearly shown that AIx and PPA predict a high risk of coronary artery disease (CAD). Objectives The aim of the study was to investigate the association between non-invasively measured aortic wave reflection (AWR) and PPA and CAD. Methods The study group consisted of 80 patients who were admitted to our institute for elective coronary angiography. We non-invasively measured augmentation pressure (AP), AIx, and PPA using radial applanation tonometry. Results When the extent of CAD was divided by no or minimal CAD, 1- or 2- and 3-vessel disease (VD), there was a significant association between the extent of CAD and AIx and PPA in patients aged <65 years, but not in patients aged ≥65 years. In multivariate regression analysis after controlling the traditional risk factors, the odds ratio of having 3VD was significant in patients aged <65 years: 2.15 (1.04–4.44; p = 0.039) per 5% increase of AIx and 2.02 (1.15–3.55; p = 0.015) per 0.05 increase of PPA, but not in patients aged ≥65 years. The severity of CAD expressed as a Gensini score showed a significant correlation with AP, AIx, and PPA in patients aged <65 years, but not in patients aged ≥65 years. Conclusion Increasing of non-invasively measured AWR and PPA is related to the severity of CAD, particularly in younger patients up to 65 years of age.</description><identifier>ISSN: 0914-5087</identifier><identifier>EISSN: 1876-4738</identifier><identifier>DOI: 10.1016/j.jjcc.2013.03.014</identifier><identifier>PMID: 23731925</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Age Factors ; Aged ; Aorta - physiopathology ; Aortic wave reflection ; Arterial Pressure - physiology ; Arterial stiffness ; Biomarkers ; Brachial Artery - physiopathology ; Cardiovascular ; Coronary artery disease ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - physiopathology ; Female ; Humans ; Male ; Middle Aged ; Pulse pressure amplification ; Pulse Wave Analysis ; Radial applanation tonometry ; Risk ; Severity of Illness Index</subject><ispartof>Journal of cardiology, 2013-08, Vol.62 (2), p.131-137</ispartof><rights>2013</rights><rights>Copyright © 2013. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-1cd6a29d2c1b0747e20422320458684125cc6a030f40c7c58c084d29cec1474d3</citedby><cites>FETCH-LOGICAL-c545t-1cd6a29d2c1b0747e20422320458684125cc6a030f40c7c58c084d29cec1474d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S091450871300124X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23731925$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cho, Sung Woo, MD</creatorcontrib><creatorcontrib>Kim, Byung Kyu, MD</creatorcontrib><creatorcontrib>Kim, Jeong Hoon, MD</creatorcontrib><creatorcontrib>Byun, Young Sup, MD</creatorcontrib><creatorcontrib>Goh, Choong Won, MD</creatorcontrib><creatorcontrib>Rhee, Kun Joo, MD</creatorcontrib><creatorcontrib>Ahn, Hyo Seung, MD</creatorcontrib><creatorcontrib>Lee, Byoung Kwon, MD</creatorcontrib><creatorcontrib>Kim, Byung Ok, MD</creatorcontrib><title>Non-invasively measured aortic wave reflection and pulse pressure amplification are related to the severity of coronary artery disease</title><title>Journal of cardiology</title><addtitle>J Cardiol</addtitle><description>Abstract Background Augmentation index (AIx) and pulse pressure amplification (PPA, here the aortic/brachial pulse pressure ratio) are an age-related emerging risk factor for cardiovascular disease. However, it has not been clearly shown that AIx and PPA predict a high risk of coronary artery disease (CAD). Objectives The aim of the study was to investigate the association between non-invasively measured aortic wave reflection (AWR) and PPA and CAD. Methods The study group consisted of 80 patients who were admitted to our institute for elective coronary angiography. We non-invasively measured augmentation pressure (AP), AIx, and PPA using radial applanation tonometry. Results When the extent of CAD was divided by no or minimal CAD, 1- or 2- and 3-vessel disease (VD), there was a significant association between the extent of CAD and AIx and PPA in patients aged <65 years, but not in patients aged ≥65 years. In multivariate regression analysis after controlling the traditional risk factors, the odds ratio of having 3VD was significant in patients aged <65 years: 2.15 (1.04–4.44; p = 0.039) per 5% increase of AIx and 2.02 (1.15–3.55; p = 0.015) per 0.05 increase of PPA, but not in patients aged ≥65 years. The severity of CAD expressed as a Gensini score showed a significant correlation with AP, AIx, and PPA in patients aged <65 years, but not in patients aged ≥65 years. Conclusion Increasing of non-invasively measured AWR and PPA is related to the severity of CAD, particularly in younger patients up to 65 years of age.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aorta - physiopathology</subject><subject>Aortic wave reflection</subject><subject>Arterial Pressure - physiology</subject><subject>Arterial stiffness</subject><subject>Biomarkers</subject><subject>Brachial Artery - physiopathology</subject><subject>Cardiovascular</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pulse pressure amplification</subject><subject>Pulse Wave Analysis</subject><subject>Radial applanation tonometry</subject><subject>Risk</subject><subject>Severity of Illness Index</subject><issn>0914-5087</issn><issn>1876-4738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ksuKFTEQhoMoznH0BVxIlm76WEmnbyCCDN5g0IUK7kKmUo1puzttku7hvIDPbZozunAhFKnNV3-Sj2LsqYCjAFG_GI7DgHiUIMoj5BLqHjuItqkL1ZTtfXaATqiigra5YI9iHABq6Nr6IbuQZVOKTlYH9uujnws3bya6jcYTn8jENZDlxofkkN-ajXigfiRMzs_czJYv6xiJL4HijnIzLaPrHZozEHZ-NClnJM_Td-KRNgounbjvOfrgZxNOmUuUm3Ux30iP2YPe5NQnd_2SfX375svV--L607sPV6-vC6xUlQqBtjaysxLFDTSqIQlKyjKfVVu3SsgKsTZQQq8AG6xahFZZ2SGhUI2y5SV7fs5dgv-5Ukx6chFpHM1Mfo1aKAAF2a7IqDyjGHyMWYFegpvy07UAvfvXg979692_hlxC5aFnd_nrzUT278gf4Rl4eQYo_3JzFHRERzOSdSEr1ta7_-e_-mccRzdn9-MPOlEc_Brm7E8LHaUG_XnfgH0BRAkgpPpW_ga9Ta16</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Cho, Sung Woo, MD</creator><creator>Kim, Byung Kyu, MD</creator><creator>Kim, Jeong Hoon, MD</creator><creator>Byun, Young Sup, MD</creator><creator>Goh, Choong Won, MD</creator><creator>Rhee, Kun Joo, MD</creator><creator>Ahn, Hyo Seung, MD</creator><creator>Lee, Byoung Kwon, MD</creator><creator>Kim, Byung Ok, MD</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201308</creationdate><title>Non-invasively measured aortic wave reflection and pulse pressure amplification are related to the severity of coronary artery disease</title><author>Cho, Sung Woo, MD ; Kim, Byung Kyu, MD ; Kim, Jeong Hoon, MD ; Byun, Young Sup, MD ; Goh, Choong Won, MD ; Rhee, Kun Joo, MD ; Ahn, Hyo Seung, MD ; Lee, Byoung Kwon, MD ; Kim, Byung Ok, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-1cd6a29d2c1b0747e20422320458684125cc6a030f40c7c58c084d29cec1474d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aorta - physiopathology</topic><topic>Aortic wave reflection</topic><topic>Arterial Pressure - physiology</topic><topic>Arterial stiffness</topic><topic>Biomarkers</topic><topic>Brachial Artery - physiopathology</topic><topic>Cardiovascular</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pulse pressure amplification</topic><topic>Pulse Wave Analysis</topic><topic>Radial applanation tonometry</topic><topic>Risk</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cho, Sung Woo, MD</creatorcontrib><creatorcontrib>Kim, Byung Kyu, MD</creatorcontrib><creatorcontrib>Kim, Jeong Hoon, MD</creatorcontrib><creatorcontrib>Byun, Young Sup, MD</creatorcontrib><creatorcontrib>Goh, Choong Won, MD</creatorcontrib><creatorcontrib>Rhee, Kun Joo, MD</creatorcontrib><creatorcontrib>Ahn, Hyo Seung, MD</creatorcontrib><creatorcontrib>Lee, Byoung Kwon, MD</creatorcontrib><creatorcontrib>Kim, Byung Ok, MD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cho, Sung Woo, MD</au><au>Kim, Byung Kyu, MD</au><au>Kim, Jeong Hoon, MD</au><au>Byun, Young Sup, MD</au><au>Goh, Choong Won, MD</au><au>Rhee, Kun Joo, MD</au><au>Ahn, Hyo Seung, MD</au><au>Lee, Byoung Kwon, MD</au><au>Kim, Byung Ok, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-invasively measured aortic wave reflection and pulse pressure amplification are related to the severity of coronary artery disease</atitle><jtitle>Journal of cardiology</jtitle><addtitle>J Cardiol</addtitle><date>2013-08</date><risdate>2013</risdate><volume>62</volume><issue>2</issue><spage>131</spage><epage>137</epage><pages>131-137</pages><issn>0914-5087</issn><eissn>1876-4738</eissn><abstract>Abstract Background Augmentation index (AIx) and pulse pressure amplification (PPA, here the aortic/brachial pulse pressure ratio) are an age-related emerging risk factor for cardiovascular disease. However, it has not been clearly shown that AIx and PPA predict a high risk of coronary artery disease (CAD). Objectives The aim of the study was to investigate the association between non-invasively measured aortic wave reflection (AWR) and PPA and CAD. Methods The study group consisted of 80 patients who were admitted to our institute for elective coronary angiography. We non-invasively measured augmentation pressure (AP), AIx, and PPA using radial applanation tonometry. Results When the extent of CAD was divided by no or minimal CAD, 1- or 2- and 3-vessel disease (VD), there was a significant association between the extent of CAD and AIx and PPA in patients aged <65 years, but not in patients aged ≥65 years. In multivariate regression analysis after controlling the traditional risk factors, the odds ratio of having 3VD was significant in patients aged <65 years: 2.15 (1.04–4.44; p = 0.039) per 5% increase of AIx and 2.02 (1.15–3.55; p = 0.015) per 0.05 increase of PPA, but not in patients aged ≥65 years. The severity of CAD expressed as a Gensini score showed a significant correlation with AP, AIx, and PPA in patients aged <65 years, but not in patients aged ≥65 years. Conclusion Increasing of non-invasively measured AWR and PPA is related to the severity of CAD, particularly in younger patients up to 65 years of age.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>23731925</pmid><doi>10.1016/j.jjcc.2013.03.014</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors Aged Aorta - physiopathology Aortic wave reflection Arterial Pressure - physiology Arterial stiffness Biomarkers Brachial Artery - physiopathology Cardiovascular Coronary artery disease Coronary Artery Disease - diagnosis Coronary Artery Disease - physiopathology Female Humans Male Middle Aged Pulse pressure amplification Pulse Wave Analysis Radial applanation tonometry Risk Severity of Illness Index |
| title | Non-invasively measured aortic wave reflection and pulse pressure amplification are related to the severity of coronary artery disease |
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