Abnormal lymphocyte function following long-term PUVA therapy for psoriasis
SUMMARY The surface markers and function of peripheral blood lymphocytes were examined in patients on long‐term therapy with methoxsalen and UV‐A radiation (PUVA). Ten patients with psoriasis were selected because they had received a high exposure to PUVA therapy, i.e., more than 200 treatments over...
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| Veröffentlicht in: | British journal of dermatology (1951) 1983-04, Vol.108 (4), p.445-450 |
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| container_end_page | 450 |
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| container_issue | 4 |
| container_start_page | 445 |
| container_title | British journal of dermatology (1951) |
| container_volume | 108 |
| creator | MORISON, W.L. WIMBERLY, J. PARRISH, J.A. BLOCH, K.J. |
| description | SUMMARY
The surface markers and function of peripheral blood lymphocytes were examined in patients on long‐term therapy with methoxsalen and UV‐A radiation (PUVA). Ten patients with psoriasis were selected because they had received a high exposure to PUVA therapy, i.e., more than 200 treatments over 2–6 years with cumulative exposure doses of 1700–6000 J/cm2 UV‐A radiation. Results were compared to those obtained with lymphocytes from untreated patients and UV‐B treated patients with psoriasis. The PUVA‐treated patients had low levels of E rosette‐forming cells in the peripheral blood and markedly impaired lymphocyte responses following stimulation with optimal and suboptimal doses of mitogens. The sensitivity of lymphocytes to in vitro treatment with PUVA was similar in the three groups of patients. The results of this study indicate that long‐term PUVA therapy alters the function and cell‐surface markers or distribution of lymphocytes. |
| doi_str_mv | 10.1111/j.1365-2133.1983.tb04597.x |
| format | Article |
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The surface markers and function of peripheral blood lymphocytes were examined in patients on long‐term therapy with methoxsalen and UV‐A radiation (PUVA). Ten patients with psoriasis were selected because they had received a high exposure to PUVA therapy, i.e., more than 200 treatments over 2–6 years with cumulative exposure doses of 1700–6000 J/cm2 UV‐A radiation. Results were compared to those obtained with lymphocytes from untreated patients and UV‐B treated patients with psoriasis. The PUVA‐treated patients had low levels of E rosette‐forming cells in the peripheral blood and markedly impaired lymphocyte responses following stimulation with optimal and suboptimal doses of mitogens. The sensitivity of lymphocytes to in vitro treatment with PUVA was similar in the three groups of patients. The results of this study indicate that long‐term PUVA therapy alters the function and cell‐surface markers or distribution of lymphocytes.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.1983.tb04597.x</identifier><identifier>PMID: 6838768</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Humans ; Leukocyte Count ; Lymphocyte Activation ; Lymphocytes - drug effects ; Lymphocytes - radiation effects ; Middle Aged ; Photochemotherapy - adverse effects ; Psoriasis - drug therapy ; Psoriasis - immunology ; Psoriasis - radiotherapy ; PUVA Therapy - adverse effects ; Ultraviolet Therapy</subject><ispartof>British journal of dermatology (1951), 1983-04, Vol.108 (4), p.445-450</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4385-8d0514a458c5227b73e81487deed99a4205f98aad25c84a9d46cf97e989b67f03</citedby><cites>FETCH-LOGICAL-c4385-8d0514a458c5227b73e81487deed99a4205f98aad25c84a9d46cf97e989b67f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.1983.tb04597.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.1983.tb04597.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6838768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MORISON, W.L.</creatorcontrib><creatorcontrib>WIMBERLY, J.</creatorcontrib><creatorcontrib>PARRISH, J.A.</creatorcontrib><creatorcontrib>BLOCH, K.J.</creatorcontrib><title>Abnormal lymphocyte function following long-term PUVA therapy for psoriasis</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>SUMMARY
The surface markers and function of peripheral blood lymphocytes were examined in patients on long‐term therapy with methoxsalen and UV‐A radiation (PUVA). Ten patients with psoriasis were selected because they had received a high exposure to PUVA therapy, i.e., more than 200 treatments over 2–6 years with cumulative exposure doses of 1700–6000 J/cm2 UV‐A radiation. Results were compared to those obtained with lymphocytes from untreated patients and UV‐B treated patients with psoriasis. The PUVA‐treated patients had low levels of E rosette‐forming cells in the peripheral blood and markedly impaired lymphocyte responses following stimulation with optimal and suboptimal doses of mitogens. The sensitivity of lymphocytes to in vitro treatment with PUVA was similar in the three groups of patients. The results of this study indicate that long‐term PUVA therapy alters the function and cell‐surface markers or distribution of lymphocytes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Lymphocyte Activation</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - radiation effects</subject><subject>Middle Aged</subject><subject>Photochemotherapy - adverse effects</subject><subject>Psoriasis - drug therapy</subject><subject>Psoriasis - immunology</subject><subject>Psoriasis - radiotherapy</subject><subject>PUVA Therapy - adverse effects</subject><subject>Ultraviolet Therapy</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMlOwzAURS0EgjJ8AlLEgl2CHduxzQKpLVCGChBiWFpO4kCKEwc7VZu_J1Wr7nkbL-5958kHgDMEI9TPxSxCOKFhjDCOkOA4alNIqGDRcgcMttEuGEAIWQhFgg_AofczCBGGFO6D_YRjzhI-AI_DtLauUiYwXdV826xrdVDM66wtbR0U1hi7KOuvwNj6K2y1q4KX949h0H5rp5quL7ig8daVypf-GOwVynh9snmPwPvtzdv4Lpw-T-7Hw2mYEcxpyHNIEVGE8ozGMUsZ1hwRznKtcyEUiSEtBFcqj2nGiRI5SbJCMC24SBNWQHwEztfcxtnfufatrEqfaWNUre3cS0T6f8cY98XLdTFz1nunC9m4slKukwjKlUk5kytdcqVLrkzKjUm57JdPN1fmaaXz7epGXZ9frfNFaXT3D7IcPVwTQntAuAaUvtXLLUC5H5kwzKj8fJrIpylJCHsdSYb_AD4Kknw</recordid><startdate>198304</startdate><enddate>198304</enddate><creator>MORISON, W.L.</creator><creator>WIMBERLY, J.</creator><creator>PARRISH, J.A.</creator><creator>BLOCH, K.J.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>198304</creationdate><title>Abnormal lymphocyte function following long-term PUVA therapy for psoriasis</title><author>MORISON, W.L. ; WIMBERLY, J. ; PARRISH, J.A. ; BLOCH, K.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4385-8d0514a458c5227b73e81487deed99a4205f98aad25c84a9d46cf97e989b67f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Lymphocyte Activation</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - radiation effects</topic><topic>Middle Aged</topic><topic>Photochemotherapy - adverse effects</topic><topic>Psoriasis - drug therapy</topic><topic>Psoriasis - immunology</topic><topic>Psoriasis - radiotherapy</topic><topic>PUVA Therapy - adverse effects</topic><topic>Ultraviolet Therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MORISON, W.L.</creatorcontrib><creatorcontrib>WIMBERLY, J.</creatorcontrib><creatorcontrib>PARRISH, J.A.</creatorcontrib><creatorcontrib>BLOCH, K.J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MORISON, W.L.</au><au>WIMBERLY, J.</au><au>PARRISH, J.A.</au><au>BLOCH, K.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal lymphocyte function following long-term PUVA therapy for psoriasis</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>1983-04</date><risdate>1983</risdate><volume>108</volume><issue>4</issue><spage>445</spage><epage>450</epage><pages>445-450</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><abstract>SUMMARY
The surface markers and function of peripheral blood lymphocytes were examined in patients on long‐term therapy with methoxsalen and UV‐A radiation (PUVA). Ten patients with psoriasis were selected because they had received a high exposure to PUVA therapy, i.e., more than 200 treatments over 2–6 years with cumulative exposure doses of 1700–6000 J/cm2 UV‐A radiation. Results were compared to those obtained with lymphocytes from untreated patients and UV‐B treated patients with psoriasis. The PUVA‐treated patients had low levels of E rosette‐forming cells in the peripheral blood and markedly impaired lymphocyte responses following stimulation with optimal and suboptimal doses of mitogens. The sensitivity of lymphocytes to in vitro treatment with PUVA was similar in the three groups of patients. The results of this study indicate that long‐term PUVA therapy alters the function and cell‐surface markers or distribution of lymphocytes.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6838768</pmid><doi>10.1111/j.1365-2133.1983.tb04597.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | British journal of dermatology (1951), 1983-04, Vol.108 (4), p.445-450 |
| issn | 0007-0963 1365-2133 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14000233 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adolescent Adult Aged Humans Leukocyte Count Lymphocyte Activation Lymphocytes - drug effects Lymphocytes - radiation effects Middle Aged Photochemotherapy - adverse effects Psoriasis - drug therapy Psoriasis - immunology Psoriasis - radiotherapy PUVA Therapy - adverse effects Ultraviolet Therapy |
| title | Abnormal lymphocyte function following long-term PUVA therapy for psoriasis |
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