Continuous Inhibition of Poly(ADP-ribose) Polymerase Does Not Reduce Reperfusion Injury in Isolated Rat Heart

Poly(ADP-ribose) polymerase (PARP), an enzyme that is important to the regulation of nuclear function, is activated by DNA strand breakage. In massive DNA damage, PARP is overactivated, exhausting nicotinamide adenine dinucleotide and leading to cell death. Recent studies have succeeded in reducing...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2013-07, Vol.62 (1), p.99-105
Hauptverfasser:	Nishizawa, Kenya, Yanagida, Shigeki, Yamagishi, Tadashi, Takayama, Eiichi, Bessho, Motoaki, Kusuhara, Masatoshi, Adachi, Takeshi, Ohsuzu, Fumitaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - physiology Benzamides - therapeutic use Biological and medical sciences Blotting, Western Cardiotonic Agents - therapeutic use Cardiovascular system Enzyme Inhibitors - therapeutic use In Vitro Techniques Magnetic Resonance Spectroscopy Male Medical sciences Myocardial Infarction - pathology Myocardial Reperfusion Injury - prevention & control Myocardium - enzymology NAD - metabolism Oncogene Protein v-akt - metabolism Pharmacology. Drug treatments Phosphocreatine - metabolism Phosphorus - metabolism Phosphorylation Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - metabolism Rats Rats, Wistar Sodium - metabolism Sodium Radioisotopes Treatment Failure Ventricular Function, Left - physiology
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