Relationship between serum adiponectin levels and age in healthy subjects and patients with type 2 diabetes
Summary Objective Serum adiponectin levels are affected by gender, body fat mass, several pathological factors or therapeutic interventions and it might be also affected by age. This study aimed to investigate the relationship between serum adiponectin levels and age in several physiological states....
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2013-08, Vol.79 (2), p.204-210 |
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| container_title | Clinical endocrinology (Oxford) |
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| creator | Obata, Yoshinari Yamada, Yuya Takahi, Yasumitsu Baden, Megu Y. Saisho, Kenji Tamba, Sachiko Yamamoto, Koji Umeda, Miyuki Furubayashi, Aiko Matsuzawa, Yuji |
| description | Summary
Objective
Serum adiponectin levels are affected by gender, body fat mass, several pathological factors or therapeutic interventions and it might be also affected by age. This study aimed to investigate the relationship between serum adiponectin levels and age in several physiological states.
Design, Patients and Measurements
The study was carried out in 21 100 healthy subjects (12 363 men and 8737 women) and 1833 patients with type 2 diabetes (1233 men and 600 women). Physical and demographic characteristics were recorded, and blood samples were collected to measure serum adiponectin levels. Using these data, we determined the relationships between serum adiponectin levels and various parameters, including age.
Results
Serum adiponectin levels increased with increasing age of healthy subjects and in patients with diabetes, in both men and women. Serum adiponectin levels were positively correlated with age in healthy subjects and patients with diabetes, in both men and women. In stepwise multiple regression analysis with serum adiponectin levels as the dependent variable and physiological characteristics as explanatory variables, age was significantly and independently associated with serum adiponectin levels in each of these groups of subjects.
Conclusions
Serum adiponectin levels are significantly and positively associated with age in healthy subjects and in patients with diabetes. This association is independent of renal function, body fat status, glucose metabolism and lipid profiles. |
| doi_str_mv | 10.1111/cen.12041 |
| format | Article |
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Objective
Serum adiponectin levels are affected by gender, body fat mass, several pathological factors or therapeutic interventions and it might be also affected by age. This study aimed to investigate the relationship between serum adiponectin levels and age in several physiological states.
Design, Patients and Measurements
The study was carried out in 21 100 healthy subjects (12 363 men and 8737 women) and 1833 patients with type 2 diabetes (1233 men and 600 women). Physical and demographic characteristics were recorded, and blood samples were collected to measure serum adiponectin levels. Using these data, we determined the relationships between serum adiponectin levels and various parameters, including age.
Results
Serum adiponectin levels increased with increasing age of healthy subjects and in patients with diabetes, in both men and women. Serum adiponectin levels were positively correlated with age in healthy subjects and patients with diabetes, in both men and women. In stepwise multiple regression analysis with serum adiponectin levels as the dependent variable and physiological characteristics as explanatory variables, age was significantly and independently associated with serum adiponectin levels in each of these groups of subjects.
Conclusions
Serum adiponectin levels are significantly and positively associated with age in healthy subjects and in patients with diabetes. This association is independent of renal function, body fat status, glucose metabolism and lipid profiles.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.12041</identifier><identifier>PMID: 22963459</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Adiponectin - blood ; Adult ; Age Factors ; Aged ; Asian Continental Ancestry Group ; Biological and medical sciences ; Diabetes Mellitus, Type 2 - blood ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Medical sciences ; Middle Aged ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2013-08, Vol.79 (2), p.204-210</ispartof><rights>2012 John Wiley & Sons Ltd</rights><rights>2014 INIST-CNRS</rights><rights>2012 John Wiley & Sons Ltd.</rights><rights>Copyright © 2013 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4211-ca0507c771151242ef3d2904e73a01b69cb0bf53c598ef6247f0cd6aea7b1ccf3</citedby><cites>FETCH-LOGICAL-c4211-ca0507c771151242ef3d2904e73a01b69cb0bf53c598ef6247f0cd6aea7b1ccf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcen.12041$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcen.12041$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27517210$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22963459$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Obata, Yoshinari</creatorcontrib><creatorcontrib>Yamada, Yuya</creatorcontrib><creatorcontrib>Takahi, Yasumitsu</creatorcontrib><creatorcontrib>Baden, Megu Y.</creatorcontrib><creatorcontrib>Saisho, Kenji</creatorcontrib><creatorcontrib>Tamba, Sachiko</creatorcontrib><creatorcontrib>Yamamoto, Koji</creatorcontrib><creatorcontrib>Umeda, Miyuki</creatorcontrib><creatorcontrib>Furubayashi, Aiko</creatorcontrib><creatorcontrib>Matsuzawa, Yuji</creatorcontrib><title>Relationship between serum adiponectin levels and age in healthy subjects and patients with type 2 diabetes</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol</addtitle><description>Summary
Objective
Serum adiponectin levels are affected by gender, body fat mass, several pathological factors or therapeutic interventions and it might be also affected by age. This study aimed to investigate the relationship between serum adiponectin levels and age in several physiological states.
Design, Patients and Measurements
The study was carried out in 21 100 healthy subjects (12 363 men and 8737 women) and 1833 patients with type 2 diabetes (1233 men and 600 women). Physical and demographic characteristics were recorded, and blood samples were collected to measure serum adiponectin levels. Using these data, we determined the relationships between serum adiponectin levels and various parameters, including age.
Results
Serum adiponectin levels increased with increasing age of healthy subjects and in patients with diabetes, in both men and women. Serum adiponectin levels were positively correlated with age in healthy subjects and patients with diabetes, in both men and women. In stepwise multiple regression analysis with serum adiponectin levels as the dependent variable and physiological characteristics as explanatory variables, age was significantly and independently associated with serum adiponectin levels in each of these groups of subjects.
Conclusions
Serum adiponectin levels are significantly and positively associated with age in healthy subjects and in patients with diabetes. This association is independent of renal function, body fat status, glucose metabolism and lipid profiles.</description><subject>Adiponectin - blood</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Asian Continental Ancestry Group</subject><subject>Biological and medical sciences</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10UFv0zAUB3ALgVg3OPAFkCWENA7Znu3Ybo6o2tahaUgMtKPlOC_UXepkcbLSb49ZuiEh4Ytl--f_s_wIecfghKVx6jCcMA45e0FmTCiZca7kSzIDAZCBUvkBOYxxDQByDvo1OeC8UCKXxYzcfcPGDr4NceU7WuKwRQw0Yj9uqK181wZ0gw-0wQdsIrWhovYn0rSzQtsMqx2NY7lOZjrrUhaGtNj6YUWHXYeU08rbFIzxDXlV2ybi2_18RH6cn31fLLOrrxeXi89Xmcs5Y5mzIEE7rRmTjOcca1HxAnLUwgIrVeFKKGspnCzmWCue6xpcpSxaXTLnanFEjqfcrm_vR4yD2fjosGlswHaMhomiKLjmkiX64R-6bsc-pNcZJnkhNfC5SurTpFzfxthjbbreb2y_MwzMnw6Y1AHz2IFk3-8Tx3KD1bN8-vIEPu6Bjc42dW-D8_Gv05JpziC508ltfYO7_1c0i7Prp9LZdMPHAX8937D9nVFaaGlury-Mvl3cLG_yL2YpfgOE1KuY</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Obata, Yoshinari</creator><creator>Yamada, Yuya</creator><creator>Takahi, Yasumitsu</creator><creator>Baden, Megu Y.</creator><creator>Saisho, Kenji</creator><creator>Tamba, Sachiko</creator><creator>Yamamoto, Koji</creator><creator>Umeda, Miyuki</creator><creator>Furubayashi, Aiko</creator><creator>Matsuzawa, Yuji</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201308</creationdate><title>Relationship between serum adiponectin levels and age in healthy subjects and patients with type 2 diabetes</title><author>Obata, Yoshinari ; Yamada, Yuya ; Takahi, Yasumitsu ; Baden, Megu Y. ; Saisho, Kenji ; Tamba, Sachiko ; Yamamoto, Koji ; Umeda, Miyuki ; Furubayashi, Aiko ; Matsuzawa, Yuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4211-ca0507c771151242ef3d2904e73a01b69cb0bf53c598ef6247f0cd6aea7b1ccf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adiponectin - blood</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Asian Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Obata, Yoshinari</creatorcontrib><creatorcontrib>Yamada, Yuya</creatorcontrib><creatorcontrib>Takahi, Yasumitsu</creatorcontrib><creatorcontrib>Baden, Megu Y.</creatorcontrib><creatorcontrib>Saisho, Kenji</creatorcontrib><creatorcontrib>Tamba, Sachiko</creatorcontrib><creatorcontrib>Yamamoto, Koji</creatorcontrib><creatorcontrib>Umeda, Miyuki</creatorcontrib><creatorcontrib>Furubayashi, Aiko</creatorcontrib><creatorcontrib>Matsuzawa, Yuji</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Obata, Yoshinari</au><au>Yamada, Yuya</au><au>Takahi, Yasumitsu</au><au>Baden, Megu Y.</au><au>Saisho, Kenji</au><au>Tamba, Sachiko</au><au>Yamamoto, Koji</au><au>Umeda, Miyuki</au><au>Furubayashi, Aiko</au><au>Matsuzawa, Yuji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between serum adiponectin levels and age in healthy subjects and patients with type 2 diabetes</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol</addtitle><date>2013-08</date><risdate>2013</risdate><volume>79</volume><issue>2</issue><spage>204</spage><epage>210</epage><pages>204-210</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objective
Serum adiponectin levels are affected by gender, body fat mass, several pathological factors or therapeutic interventions and it might be also affected by age. This study aimed to investigate the relationship between serum adiponectin levels and age in several physiological states.
Design, Patients and Measurements
The study was carried out in 21 100 healthy subjects (12 363 men and 8737 women) and 1833 patients with type 2 diabetes (1233 men and 600 women). Physical and demographic characteristics were recorded, and blood samples were collected to measure serum adiponectin levels. Using these data, we determined the relationships between serum adiponectin levels and various parameters, including age.
Results
Serum adiponectin levels increased with increasing age of healthy subjects and in patients with diabetes, in both men and women. Serum adiponectin levels were positively correlated with age in healthy subjects and patients with diabetes, in both men and women. In stepwise multiple regression analysis with serum adiponectin levels as the dependent variable and physiological characteristics as explanatory variables, age was significantly and independently associated with serum adiponectin levels in each of these groups of subjects.
Conclusions
Serum adiponectin levels are significantly and positively associated with age in healthy subjects and in patients with diabetes. This association is independent of renal function, body fat status, glucose metabolism and lipid profiles.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>22963459</pmid><doi>10.1111/cen.12041</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-0664 |
| ispartof | Clinical endocrinology (Oxford), 2013-08, Vol.79 (2), p.204-210 |
| issn | 0300-0664 1365-2265 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Adiponectin - blood Adult Age Factors Aged Asian Continental Ancestry Group Biological and medical sciences Diabetes Mellitus, Type 2 - blood Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Fundamental and applied biological sciences. Psychology Humans Male Medical sciences Middle Aged Vertebrates: endocrinology |
| title | Relationship between serum adiponectin levels and age in healthy subjects and patients with type 2 diabetes |
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