PON1-108 TT and PON1-192 RR genotypes are more frequently encountered in Greek PCOS than non-PCOS women, and are associated with hyperandrogenaemia
Summary Objective To investigate the frequencies of three paraoxonase (PON)1 polymorphisms in Greek polycystic ovary syndrome (PCOS) and non‐PCOS women, and their genotypes association with hyperandrogenaemia and insulin resistance. Design Case–control genetic association study. Setting University H...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2013-08, Vol.79 (2), p.259-266 |
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| creator | Paltoglou, George Tavernarakis, George Christopoulos, Panagiotis Vlassi, Margarita Gazouli, Maria Deligeoroglou, Efthimios Creatsas, George Mastorakos, George |
| description | Summary
Objective
To investigate the frequencies of three paraoxonase (PON)1 polymorphisms in Greek polycystic ovary syndrome (PCOS) and non‐PCOS women, and their genotypes association with hyperandrogenaemia and insulin resistance.
Design
Case–control genetic association study.
Setting
University Hospital Endocrine Unit.
Patients
A total of 142 PCOS cases (NIH criteria) and 112 controls.
Main Outcome Measure
Genotyping of the c.–108C>T (PON1‐108), the c.163T>A (PON1‐55) and the c.575A>G (PON1‐192) polymorphisms and measurement of baseline androgen and insulin resistance profile.
Results
The PON1‐108 TT and PON1‐192 RR genotypes were more frequently encountered in the PCOS than in the control group. The PON1‐192 R allele frequency was greater in the PCOS than in the control group. Comparing the PCOS and the control groups, statistical significances favoured a recessive and a dominant genetic model, respectively, for the single PON1‐108 T and PON1‐192 R alleles. Free Androgen Index (FAI) levels were higher in patients with PON1‐108 TT, whereas Testosterone, FAI and Dehydroepiandrosterone sulphate (DHEAS) levels were higher in patients with PON1‐192 RR than patients with the wild or the heterozygous genotype.
Conclusions
The decreased PON1 activity‐associated PON1‐108 TT and the PON1‐192 RR genotypes are more frequently found in Greek PCOS women and are associated with hyperandrogenaemia. Hyperandrogenaemia must depend also on other genetic factors because the same genotypes were not associated with hyperandrogenaemia in the control group. Through identification of the involved polymorphisms, women with PCOS could potentially have a better therapeutic screening. |
| doi_str_mv | 10.1111/cen.12139 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1399924645</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1399924645</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4219-8597677172ac4217f4ca823da39a82262f3e95f313f234e5db11cc644bc983bb3</originalsourceid><addsrcrecordid>eNp1kd9u0zAUxiMEYt3gghdAlhASSGTznzhOLlG0FaSqrUZhiBvLcU5otsQudqKuz8EL4zbdkJDwha1j_845_s4XRa8IPidhXWgw54QSlj-JJoSlPKY05U-jCWYYxzhNk5Po1PtbjDHPsHgenVBGRUZZMol-LxdzEhOcodUKKVOhMc4pur5GP8HYfrcBj5QD1Nmw1Q5-DWD6dofAaDuYHhxUqDFo6gDu0LJYfEH9WhlkrIkP0dZ2YD4ciu_LKO-tblQfsrZNv0br0MCFR2dDOwVdo15Ez2rVenh5PM-ir1eXq-JTPFtMPxcfZ7FOKMnjjOciFYIIqvYXok60CqIqxfJw0pTWDHJeM8LqIBV4VRKidZokpc4zVpbsLHo31t04G0T5XnaN19C2yoAdvAwDzXOapAkP6Jt_0Fs7OBN-JwmnOReY0TRQ70dKO-u9g1puXNMpt5MEy71TMjglD04F9vWx4lB2UD2SD9YE4O0RUF6rtg4z0o3_ywkelJMscBcjt21a2P2_oywu5w-t4zGj8T3cP2YodydTwQSXN_OpvCm-_ZhfLb_LGfsDB1O2GQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1529570326</pqid></control><display><type>article</type><title>PON1-108 TT and PON1-192 RR genotypes are more frequently encountered in Greek PCOS than non-PCOS women, and are associated with hyperandrogenaemia</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Paltoglou, George ; Tavernarakis, George ; Christopoulos, Panagiotis ; Vlassi, Margarita ; Gazouli, Maria ; Deligeoroglou, Efthimios ; Creatsas, George ; Mastorakos, George</creator><creatorcontrib>Paltoglou, George ; Tavernarakis, George ; Christopoulos, Panagiotis ; Vlassi, Margarita ; Gazouli, Maria ; Deligeoroglou, Efthimios ; Creatsas, George ; Mastorakos, George</creatorcontrib><description>Summary
Objective
To investigate the frequencies of three paraoxonase (PON)1 polymorphisms in Greek polycystic ovary syndrome (PCOS) and non‐PCOS women, and their genotypes association with hyperandrogenaemia and insulin resistance.
Design
Case–control genetic association study.
Setting
University Hospital Endocrine Unit.
Patients
A total of 142 PCOS cases (NIH criteria) and 112 controls.
Main Outcome Measure
Genotyping of the c.–108C>T (PON1‐108), the c.163T>A (PON1‐55) and the c.575A>G (PON1‐192) polymorphisms and measurement of baseline androgen and insulin resistance profile.
Results
The PON1‐108 TT and PON1‐192 RR genotypes were more frequently encountered in the PCOS than in the control group. The PON1‐192 R allele frequency was greater in the PCOS than in the control group. Comparing the PCOS and the control groups, statistical significances favoured a recessive and a dominant genetic model, respectively, for the single PON1‐108 T and PON1‐192 R alleles. Free Androgen Index (FAI) levels were higher in patients with PON1‐108 TT, whereas Testosterone, FAI and Dehydroepiandrosterone sulphate (DHEAS) levels were higher in patients with PON1‐192 RR than patients with the wild or the heterozygous genotype.
Conclusions
The decreased PON1 activity‐associated PON1‐108 TT and the PON1‐192 RR genotypes are more frequently found in Greek PCOS women and are associated with hyperandrogenaemia. Hyperandrogenaemia must depend also on other genetic factors because the same genotypes were not associated with hyperandrogenaemia in the control group. Through identification of the involved polymorphisms, women with PCOS could potentially have a better therapeutic screening.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.12139</identifier><identifier>PMID: 23278234</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Adult ; Androgens - blood ; Aryldialkylphosphatase - genetics ; Bacterial diseases ; Bacterial diseases of the nervous system. Bacterial myositis ; Biological and medical sciences ; Case-Control Studies ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Genetic Association Studies ; Genotype ; Greece ; Human bacterial diseases ; Humans ; Hyperandrogenism - genetics ; Infectious diseases ; Insulin resistance ; Insulin Resistance - genetics ; Medical sciences ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - genetics ; Polymorphism, Genetic ; Vertebrates: endocrinology ; Women</subject><ispartof>Clinical endocrinology (Oxford), 2013-08, Vol.79 (2), p.259-266</ispartof><rights>2012 John Wiley & Sons Ltd</rights><rights>2014 INIST-CNRS</rights><rights>2012 John Wiley & Sons Ltd.</rights><rights>Copyright © 2013 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4219-8597677172ac4217f4ca823da39a82262f3e95f313f234e5db11cc644bc983bb3</citedby><cites>FETCH-LOGICAL-c4219-8597677172ac4217f4ca823da39a82262f3e95f313f234e5db11cc644bc983bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcen.12139$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcen.12139$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27517218$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23278234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paltoglou, George</creatorcontrib><creatorcontrib>Tavernarakis, George</creatorcontrib><creatorcontrib>Christopoulos, Panagiotis</creatorcontrib><creatorcontrib>Vlassi, Margarita</creatorcontrib><creatorcontrib>Gazouli, Maria</creatorcontrib><creatorcontrib>Deligeoroglou, Efthimios</creatorcontrib><creatorcontrib>Creatsas, George</creatorcontrib><creatorcontrib>Mastorakos, George</creatorcontrib><title>PON1-108 TT and PON1-192 RR genotypes are more frequently encountered in Greek PCOS than non-PCOS women, and are associated with hyperandrogenaemia</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol</addtitle><description>Summary
Objective
To investigate the frequencies of three paraoxonase (PON)1 polymorphisms in Greek polycystic ovary syndrome (PCOS) and non‐PCOS women, and their genotypes association with hyperandrogenaemia and insulin resistance.
Design
Case–control genetic association study.
Setting
University Hospital Endocrine Unit.
Patients
A total of 142 PCOS cases (NIH criteria) and 112 controls.
Main Outcome Measure
Genotyping of the c.–108C>T (PON1‐108), the c.163T>A (PON1‐55) and the c.575A>G (PON1‐192) polymorphisms and measurement of baseline androgen and insulin resistance profile.
Results
The PON1‐108 TT and PON1‐192 RR genotypes were more frequently encountered in the PCOS than in the control group. The PON1‐192 R allele frequency was greater in the PCOS than in the control group. Comparing the PCOS and the control groups, statistical significances favoured a recessive and a dominant genetic model, respectively, for the single PON1‐108 T and PON1‐192 R alleles. Free Androgen Index (FAI) levels were higher in patients with PON1‐108 TT, whereas Testosterone, FAI and Dehydroepiandrosterone sulphate (DHEAS) levels were higher in patients with PON1‐192 RR than patients with the wild or the heterozygous genotype.
Conclusions
The decreased PON1 activity‐associated PON1‐108 TT and the PON1‐192 RR genotypes are more frequently found in Greek PCOS women and are associated with hyperandrogenaemia. Hyperandrogenaemia must depend also on other genetic factors because the same genotypes were not associated with hyperandrogenaemia in the control group. Through identification of the involved polymorphisms, women with PCOS could potentially have a better therapeutic screening.</description><subject>Adult</subject><subject>Androgens - blood</subject><subject>Aryldialkylphosphatase - genetics</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the nervous system. Bacterial myositis</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>Genetic Association Studies</subject><subject>Genotype</subject><subject>Greece</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Hyperandrogenism - genetics</subject><subject>Infectious diseases</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - genetics</subject><subject>Medical sciences</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Vertebrates: endocrinology</subject><subject>Women</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kd9u0zAUxiMEYt3gghdAlhASSGTznzhOLlG0FaSqrUZhiBvLcU5otsQudqKuz8EL4zbdkJDwha1j_845_s4XRa8IPidhXWgw54QSlj-JJoSlPKY05U-jCWYYxzhNk5Po1PtbjDHPsHgenVBGRUZZMol-LxdzEhOcodUKKVOhMc4pur5GP8HYfrcBj5QD1Nmw1Q5-DWD6dofAaDuYHhxUqDFo6gDu0LJYfEH9WhlkrIkP0dZ2YD4ciu_LKO-tblQfsrZNv0br0MCFR2dDOwVdo15Ez2rVenh5PM-ir1eXq-JTPFtMPxcfZ7FOKMnjjOciFYIIqvYXok60CqIqxfJw0pTWDHJeM8LqIBV4VRKidZokpc4zVpbsLHo31t04G0T5XnaN19C2yoAdvAwDzXOapAkP6Jt_0Fs7OBN-JwmnOReY0TRQ70dKO-u9g1puXNMpt5MEy71TMjglD04F9vWx4lB2UD2SD9YE4O0RUF6rtg4z0o3_ywkelJMscBcjt21a2P2_oywu5w-t4zGj8T3cP2YodydTwQSXN_OpvCm-_ZhfLb_LGfsDB1O2GQ</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Paltoglou, George</creator><creator>Tavernarakis, George</creator><creator>Christopoulos, Panagiotis</creator><creator>Vlassi, Margarita</creator><creator>Gazouli, Maria</creator><creator>Deligeoroglou, Efthimios</creator><creator>Creatsas, George</creator><creator>Mastorakos, George</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201308</creationdate><title>PON1-108 TT and PON1-192 RR genotypes are more frequently encountered in Greek PCOS than non-PCOS women, and are associated with hyperandrogenaemia</title><author>Paltoglou, George ; Tavernarakis, George ; Christopoulos, Panagiotis ; Vlassi, Margarita ; Gazouli, Maria ; Deligeoroglou, Efthimios ; Creatsas, George ; Mastorakos, George</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4219-8597677172ac4217f4ca823da39a82262f3e95f313f234e5db11cc644bc983bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Androgens - blood</topic><topic>Aryldialkylphosphatase - genetics</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the nervous system. Bacterial myositis</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Frequency</topic><topic>Genetic Association Studies</topic><topic>Genotype</topic><topic>Greece</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Hyperandrogenism - genetics</topic><topic>Infectious diseases</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - genetics</topic><topic>Medical sciences</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Vertebrates: endocrinology</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paltoglou, George</creatorcontrib><creatorcontrib>Tavernarakis, George</creatorcontrib><creatorcontrib>Christopoulos, Panagiotis</creatorcontrib><creatorcontrib>Vlassi, Margarita</creatorcontrib><creatorcontrib>Gazouli, Maria</creatorcontrib><creatorcontrib>Deligeoroglou, Efthimios</creatorcontrib><creatorcontrib>Creatsas, George</creatorcontrib><creatorcontrib>Mastorakos, George</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paltoglou, George</au><au>Tavernarakis, George</au><au>Christopoulos, Panagiotis</au><au>Vlassi, Margarita</au><au>Gazouli, Maria</au><au>Deligeoroglou, Efthimios</au><au>Creatsas, George</au><au>Mastorakos, George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PON1-108 TT and PON1-192 RR genotypes are more frequently encountered in Greek PCOS than non-PCOS women, and are associated with hyperandrogenaemia</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol</addtitle><date>2013-08</date><risdate>2013</risdate><volume>79</volume><issue>2</issue><spage>259</spage><epage>266</epage><pages>259-266</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objective
To investigate the frequencies of three paraoxonase (PON)1 polymorphisms in Greek polycystic ovary syndrome (PCOS) and non‐PCOS women, and their genotypes association with hyperandrogenaemia and insulin resistance.
Design
Case–control genetic association study.
Setting
University Hospital Endocrine Unit.
Patients
A total of 142 PCOS cases (NIH criteria) and 112 controls.
Main Outcome Measure
Genotyping of the c.–108C>T (PON1‐108), the c.163T>A (PON1‐55) and the c.575A>G (PON1‐192) polymorphisms and measurement of baseline androgen and insulin resistance profile.
Results
The PON1‐108 TT and PON1‐192 RR genotypes were more frequently encountered in the PCOS than in the control group. The PON1‐192 R allele frequency was greater in the PCOS than in the control group. Comparing the PCOS and the control groups, statistical significances favoured a recessive and a dominant genetic model, respectively, for the single PON1‐108 T and PON1‐192 R alleles. Free Androgen Index (FAI) levels were higher in patients with PON1‐108 TT, whereas Testosterone, FAI and Dehydroepiandrosterone sulphate (DHEAS) levels were higher in patients with PON1‐192 RR than patients with the wild or the heterozygous genotype.
Conclusions
The decreased PON1 activity‐associated PON1‐108 TT and the PON1‐192 RR genotypes are more frequently found in Greek PCOS women and are associated with hyperandrogenaemia. Hyperandrogenaemia must depend also on other genetic factors because the same genotypes were not associated with hyperandrogenaemia in the control group. Through identification of the involved polymorphisms, women with PCOS could potentially have a better therapeutic screening.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>23278234</pmid><doi>10.1111/cen.12139</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-0664 |
| ispartof | Clinical endocrinology (Oxford), 2013-08, Vol.79 (2), p.259-266 |
| issn | 0300-0664 1365-2265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1399924645 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Androgens - blood Aryldialkylphosphatase - genetics Bacterial diseases Bacterial diseases of the nervous system. Bacterial myositis Biological and medical sciences Case-Control Studies Endocrinopathies Female Fundamental and applied biological sciences. Psychology Gene Frequency Genetic Association Studies Genotype Greece Human bacterial diseases Humans Hyperandrogenism - genetics Infectious diseases Insulin resistance Insulin Resistance - genetics Medical sciences Polycystic ovary syndrome Polycystic Ovary Syndrome - genetics Polymorphism, Genetic Vertebrates: endocrinology Women |
| title | PON1-108 TT and PON1-192 RR genotypes are more frequently encountered in Greek PCOS than non-PCOS women, and are associated with hyperandrogenaemia |
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