Restless legs syndrome in end-stage renal disease: a multicenter study in Taiwan
Background and purpose Restless legs syndrome (RLS) is an underestimated movement disorder in patients with end‐stage renal disease (ESRD). Several clinical and laboratory factors were inconsistently reported to associate with RLS. We aim to perform a large‐scale multicenter study to investigate the...
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| Veröffentlicht in: | European journal of neurology 2013-07, Vol.20 (7), p.1025-1031 |
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| container_title | European journal of neurology |
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| creator | Lin, C.-H. Wu, V.-C. Li, W.-Y. Sy, H.-N. Wu, S.-L. Chang, C.-C. Chiu, P.-F. Lion, H.-H. Lin, C.-Y. Chang, H.-W. Lin, S.-Y. Wu, K.-D. Chen, Y.-M. Wu, R.-M. |
| description | Background and purpose
Restless legs syndrome (RLS) is an underestimated movement disorder in patients with end‐stage renal disease (ESRD). Several clinical and laboratory factors were inconsistently reported to associate with RLS. We aim to perform a large‐scale multicenter study to investigate the possible associated risk factors of RLS in patients with ESRD in Taiwan, a country with the highest incidence of uremia in the world.
Methods
From October 2009 to October 2011, we constitutively recruited 1130 patients with ESRD from 17 hemodialysis centers. Demographic, laboratory data, presence and severity of RLS were collected. Odds ratios (ORs) were estimated by logistic regression models.
Results
We found the prevalence of RLS to be 25.3% in patients with ESRD. Having type 2 diabetes [OR = 3.61 (2.27–5.77), P |
| doi_str_mv | 10.1111/ene.12095 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1399923365</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1366820426</sourcerecordid><originalsourceid>FETCH-LOGICAL-i4165-90ab050c74560f20e9c2830e807b18402c7c211776eb4a4decdbb6df37e43a2b3</originalsourceid><addsrcrecordid>eNqNkUlLxEAQhRtR3A_-AWnw4iVavSfeRMZRccft1nSSGmlNMppO0Pn39syoB0_WpQrqewWvHiFbDPZYrH1scI9xyNQCWWVSpwkTgi3GWSiWKAZshayF8AIA3HBYJitcCJ2B1Kvk-hZDV2EItMLnQMOkKdtxjdQ3FJsyCZ17Rtpi4ypa-oAu4AF1tO6rzhfYdNjS0PXlZMrfOf_hmg2yNHJVwM3vvk7ujwd3RyfJ-dXw9OjwPPGSaZVk4HJQUBipNIw4YFbwVACmYHKWSuCFKThjxmjMpZMlFmWe63IkDErheC7Wye787ls7fu-jCVv7UGBVuQbHfbBMZFk29an-gWqdcpBcR3TnD_oy7tvofkapzCijIVLb31Sf11jat9bXrp3Yn7dGYH8OfPgKJ797Bnaal4152VlednA5mA1RkcwVPnT4-atw7avVRhhlHy-HVp8NL54ebpjV4gv_SZRL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1365975760</pqid></control><display><type>article</type><title>Restless legs syndrome in end-stage renal disease: a multicenter study in Taiwan</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lin, C.-H. ; Wu, V.-C. ; Li, W.-Y. ; Sy, H.-N. ; Wu, S.-L. ; Chang, C.-C. ; Chiu, P.-F. ; Lion, H.-H. ; Lin, C.-Y. ; Chang, H.-W. ; Lin, S.-Y. ; Wu, K.-D. ; Chen, Y.-M. ; Wu, R.-M.</creator><creatorcontrib>Lin, C.-H. ; Wu, V.-C. ; Li, W.-Y. ; Sy, H.-N. ; Wu, S.-L. ; Chang, C.-C. ; Chiu, P.-F. ; Lion, H.-H. ; Lin, C.-Y. ; Chang, H.-W. ; Lin, S.-Y. ; Wu, K.-D. ; Chen, Y.-M. ; Wu, R.-M.</creatorcontrib><description><![CDATA[Background and purpose
Restless legs syndrome (RLS) is an underestimated movement disorder in patients with end‐stage renal disease (ESRD). Several clinical and laboratory factors were inconsistently reported to associate with RLS. We aim to perform a large‐scale multicenter study to investigate the possible associated risk factors of RLS in patients with ESRD in Taiwan, a country with the highest incidence of uremia in the world.
Methods
From October 2009 to October 2011, we constitutively recruited 1130 patients with ESRD from 17 hemodialysis centers. Demographic, laboratory data, presence and severity of RLS were collected. Odds ratios (ORs) were estimated by logistic regression models.
Results
We found the prevalence of RLS to be 25.3% in patients with ESRD. Having type 2 diabetes [OR = 3.61 (2.27–5.77), P < 0.01], low serum transferrin saturation [OR = 1.42 (1.01–2.03), P < 0.05] and duration of dialysis [OR = 1.09 (1.03–1.14), P < 0.01] were associated with RLS. In contrast, high serum hemoglobin level was inversely associated with RLS [OR = 0.61 (0.40–0.89), P < 0.05]. RLS has a significant impact on sleep quality in dialysis patients. Among patients with RLS, history of type 2 diabetes [OR = 4.04 (1.65–10.79), P < 0.05], low serum hemoglobin level [OR = 5.41 (2.43–13.12), P < 0.01] and duration of dialysis [OR = 1.01 (1.01–1.02), P < 0.01] were associated with increased severity of RLS.
Conclusions
Our findings demonstrated that RLS is common in Taiwanese dialysis patients. Clinicians should have a high suspicion for the presence of RLS symptoms in patients with ESRD, especially those with type 2 diabetes, anemia, low serum iron status and long duration of dialysis.]]></description><identifier>ISSN: 1351-5101</identifier><identifier>EISSN: 1468-1331</identifier><identifier>DOI: 10.1111/ene.12095</identifier><identifier>PMID: 23369046</identifier><identifier>CODEN: EJNEFL</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Diabetes ; dialysis ; end-stage renal disease ; Female ; Hemodialysis ; Humans ; Kidney diseases ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - epidemiology ; Male ; Middle Aged ; Prevalence ; Renal Dialysis - statistics & numerical data ; Restless legs syndrome ; Restless Legs Syndrome - complications ; Restless Legs Syndrome - epidemiology ; Risk Factors ; Taiwan - epidemiology</subject><ispartof>European journal of neurology, 2013-07, Vol.20 (7), p.1025-1031</ispartof><rights>2013 The Author(s) European Journal of Neurology © 2013 EFNS</rights><rights>2013 The Author(s) European Journal of Neurology © 2013 EFNS.</rights><rights>European Journal of Neurology © 2013 European Federation of Neurological Societies</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fene.12095$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fene.12095$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23369046$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, C.-H.</creatorcontrib><creatorcontrib>Wu, V.-C.</creatorcontrib><creatorcontrib>Li, W.-Y.</creatorcontrib><creatorcontrib>Sy, H.-N.</creatorcontrib><creatorcontrib>Wu, S.-L.</creatorcontrib><creatorcontrib>Chang, C.-C.</creatorcontrib><creatorcontrib>Chiu, P.-F.</creatorcontrib><creatorcontrib>Lion, H.-H.</creatorcontrib><creatorcontrib>Lin, C.-Y.</creatorcontrib><creatorcontrib>Chang, H.-W.</creatorcontrib><creatorcontrib>Lin, S.-Y.</creatorcontrib><creatorcontrib>Wu, K.-D.</creatorcontrib><creatorcontrib>Chen, Y.-M.</creatorcontrib><creatorcontrib>Wu, R.-M.</creatorcontrib><title>Restless legs syndrome in end-stage renal disease: a multicenter study in Taiwan</title><title>European journal of neurology</title><addtitle>Eur J Neurol</addtitle><description><![CDATA[Background and purpose
Restless legs syndrome (RLS) is an underestimated movement disorder in patients with end‐stage renal disease (ESRD). Several clinical and laboratory factors were inconsistently reported to associate with RLS. We aim to perform a large‐scale multicenter study to investigate the possible associated risk factors of RLS in patients with ESRD in Taiwan, a country with the highest incidence of uremia in the world.
Methods
From October 2009 to October 2011, we constitutively recruited 1130 patients with ESRD from 17 hemodialysis centers. Demographic, laboratory data, presence and severity of RLS were collected. Odds ratios (ORs) were estimated by logistic regression models.
Results
We found the prevalence of RLS to be 25.3% in patients with ESRD. Having type 2 diabetes [OR = 3.61 (2.27–5.77), P < 0.01], low serum transferrin saturation [OR = 1.42 (1.01–2.03), P < 0.05] and duration of dialysis [OR = 1.09 (1.03–1.14), P < 0.01] were associated with RLS. In contrast, high serum hemoglobin level was inversely associated with RLS [OR = 0.61 (0.40–0.89), P < 0.05]. RLS has a significant impact on sleep quality in dialysis patients. Among patients with RLS, history of type 2 diabetes [OR = 4.04 (1.65–10.79), P < 0.05], low serum hemoglobin level [OR = 5.41 (2.43–13.12), P < 0.01] and duration of dialysis [OR = 1.01 (1.01–1.02), P < 0.01] were associated with increased severity of RLS.
Conclusions
Our findings demonstrated that RLS is common in Taiwanese dialysis patients. Clinicians should have a high suspicion for the presence of RLS symptoms in patients with ESRD, especially those with type 2 diabetes, anemia, low serum iron status and long duration of dialysis.]]></description><subject>Diabetes</subject><subject>dialysis</subject><subject>end-stage renal disease</subject><subject>Female</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Renal Dialysis - statistics & numerical data</subject><subject>Restless legs syndrome</subject><subject>Restless Legs Syndrome - complications</subject><subject>Restless Legs Syndrome - epidemiology</subject><subject>Risk Factors</subject><subject>Taiwan - epidemiology</subject><issn>1351-5101</issn><issn>1468-1331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUlLxEAQhRtR3A_-AWnw4iVavSfeRMZRccft1nSSGmlNMppO0Pn39syoB0_WpQrqewWvHiFbDPZYrH1scI9xyNQCWWVSpwkTgi3GWSiWKAZshayF8AIA3HBYJitcCJ2B1Kvk-hZDV2EItMLnQMOkKdtxjdQ3FJsyCZ17Rtpi4ypa-oAu4AF1tO6rzhfYdNjS0PXlZMrfOf_hmg2yNHJVwM3vvk7ujwd3RyfJ-dXw9OjwPPGSaZVk4HJQUBipNIw4YFbwVACmYHKWSuCFKThjxmjMpZMlFmWe63IkDErheC7Wye787ls7fu-jCVv7UGBVuQbHfbBMZFk29an-gWqdcpBcR3TnD_oy7tvofkapzCijIVLb31Sf11jat9bXrp3Yn7dGYH8OfPgKJ797Bnaal4152VlednA5mA1RkcwVPnT4-atw7avVRhhlHy-HVp8NL54ebpjV4gv_SZRL</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Lin, C.-H.</creator><creator>Wu, V.-C.</creator><creator>Li, W.-Y.</creator><creator>Sy, H.-N.</creator><creator>Wu, S.-L.</creator><creator>Chang, C.-C.</creator><creator>Chiu, P.-F.</creator><creator>Lion, H.-H.</creator><creator>Lin, C.-Y.</creator><creator>Chang, H.-W.</creator><creator>Lin, S.-Y.</creator><creator>Wu, K.-D.</creator><creator>Chen, Y.-M.</creator><creator>Wu, R.-M.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201307</creationdate><title>Restless legs syndrome in end-stage renal disease: a multicenter study in Taiwan</title><author>Lin, C.-H. ; Wu, V.-C. ; Li, W.-Y. ; Sy, H.-N. ; Wu, S.-L. ; Chang, C.-C. ; Chiu, P.-F. ; Lion, H.-H. ; Lin, C.-Y. ; Chang, H.-W. ; Lin, S.-Y. ; Wu, K.-D. ; Chen, Y.-M. ; Wu, R.-M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i4165-90ab050c74560f20e9c2830e807b18402c7c211776eb4a4decdbb6df37e43a2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Diabetes</topic><topic>dialysis</topic><topic>end-stage renal disease</topic><topic>Female</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Kidney Failure, Chronic - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Renal Dialysis - statistics & numerical data</topic><topic>Restless legs syndrome</topic><topic>Restless Legs Syndrome - complications</topic><topic>Restless Legs Syndrome - epidemiology</topic><topic>Risk Factors</topic><topic>Taiwan - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, C.-H.</creatorcontrib><creatorcontrib>Wu, V.-C.</creatorcontrib><creatorcontrib>Li, W.-Y.</creatorcontrib><creatorcontrib>Sy, H.-N.</creatorcontrib><creatorcontrib>Wu, S.-L.</creatorcontrib><creatorcontrib>Chang, C.-C.</creatorcontrib><creatorcontrib>Chiu, P.-F.</creatorcontrib><creatorcontrib>Lion, H.-H.</creatorcontrib><creatorcontrib>Lin, C.-Y.</creatorcontrib><creatorcontrib>Chang, H.-W.</creatorcontrib><creatorcontrib>Lin, S.-Y.</creatorcontrib><creatorcontrib>Wu, K.-D.</creatorcontrib><creatorcontrib>Chen, Y.-M.</creatorcontrib><creatorcontrib>Wu, R.-M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, C.-H.</au><au>Wu, V.-C.</au><au>Li, W.-Y.</au><au>Sy, H.-N.</au><au>Wu, S.-L.</au><au>Chang, C.-C.</au><au>Chiu, P.-F.</au><au>Lion, H.-H.</au><au>Lin, C.-Y.</au><au>Chang, H.-W.</au><au>Lin, S.-Y.</au><au>Wu, K.-D.</au><au>Chen, Y.-M.</au><au>Wu, R.-M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Restless legs syndrome in end-stage renal disease: a multicenter study in Taiwan</atitle><jtitle>European journal of neurology</jtitle><addtitle>Eur J Neurol</addtitle><date>2013-07</date><risdate>2013</risdate><volume>20</volume><issue>7</issue><spage>1025</spage><epage>1031</epage><pages>1025-1031</pages><issn>1351-5101</issn><eissn>1468-1331</eissn><coden>EJNEFL</coden><abstract><![CDATA[Background and purpose
Restless legs syndrome (RLS) is an underestimated movement disorder in patients with end‐stage renal disease (ESRD). Several clinical and laboratory factors were inconsistently reported to associate with RLS. We aim to perform a large‐scale multicenter study to investigate the possible associated risk factors of RLS in patients with ESRD in Taiwan, a country with the highest incidence of uremia in the world.
Methods
From October 2009 to October 2011, we constitutively recruited 1130 patients with ESRD from 17 hemodialysis centers. Demographic, laboratory data, presence and severity of RLS were collected. Odds ratios (ORs) were estimated by logistic regression models.
Results
We found the prevalence of RLS to be 25.3% in patients with ESRD. Having type 2 diabetes [OR = 3.61 (2.27–5.77), P < 0.01], low serum transferrin saturation [OR = 1.42 (1.01–2.03), P < 0.05] and duration of dialysis [OR = 1.09 (1.03–1.14), P < 0.01] were associated with RLS. In contrast, high serum hemoglobin level was inversely associated with RLS [OR = 0.61 (0.40–0.89), P < 0.05]. RLS has a significant impact on sleep quality in dialysis patients. Among patients with RLS, history of type 2 diabetes [OR = 4.04 (1.65–10.79), P < 0.05], low serum hemoglobin level [OR = 5.41 (2.43–13.12), P < 0.01] and duration of dialysis [OR = 1.01 (1.01–1.02), P < 0.01] were associated with increased severity of RLS.
Conclusions
Our findings demonstrated that RLS is common in Taiwanese dialysis patients. Clinicians should have a high suspicion for the presence of RLS symptoms in patients with ESRD, especially those with type 2 diabetes, anemia, low serum iron status and long duration of dialysis.]]></abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23369046</pmid><doi>10.1111/ene.12095</doi><tpages>7</tpages></addata></record> |
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| subjects | Diabetes dialysis end-stage renal disease Female Hemodialysis Humans Kidney diseases Kidney Failure, Chronic - complications Kidney Failure, Chronic - epidemiology Male Middle Aged Prevalence Renal Dialysis - statistics & numerical data Restless legs syndrome Restless Legs Syndrome - complications Restless Legs Syndrome - epidemiology Risk Factors Taiwan - epidemiology |
| title | Restless legs syndrome in end-stage renal disease: a multicenter study in Taiwan |
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