A novel synthetic lipopeptide is allergy-protective by the induction of LPS-tolerance

Summary Background Exposure to the environment of traditional farms can protect children from some allergic disease. Due to this exposure, TLR2 expression in these children is increased. TLR2 ligands derived from gram‐positive bacteria are found in the dust of these farms. Objectives We proved wheth...

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Veröffentlicht in:	Clinical and experimental allergy 2013-07, Vol.43 (7), p.785-797
Hauptverfasser:	Stiehm, M., Peters, K., Wiesmüller, K.-H., Bufe, A., Peters, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies Animals asthma Asthma - chemically induced Asthma - drug therapy Asthma - immunology Bacillus cereus Bacillus cereus - chemistry Bacterial Proteins - chemical synthesis Bacterial Proteins - chemistry Bacterial Proteins - pharmacology Bone Marrow Cells - immunology Bone Marrow Cells - pathology Dendritic Cells - immunology Dendritic Cells - pathology Disease Models, Animal farming environment Female Gram-positive bacteria Immune Tolerance - drug effects Immune Tolerance - genetics Lipopeptides - chemical synthesis Lipopeptides - chemistry Lipopeptides - pharmacology Lipopolysaccharides - toxicity Medical research Mice Mice, Inbred BALB C Mice, Knockout murine models Rodents Toll-Like Receptor 1 - agonists Toll-Like Receptor 1 - genetics Toll-Like Receptor 1 - immunology Toll-Like Receptor 2 - agonists Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - immunology
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