CRISPR-mediated adaptive immune systems in bacteria and archaea

Effective clearance of an infection requires that the immune system rapidly detects and neutralizes invading parasites while strictly avoiding self-antigens that would result in autoimmunity. The cellular machinery and complex signaling pathways that coordinate an effective immune response have gene...

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Veröffentlicht in:	Annual review of biochemistry 2013-01, Vol.82 (1), p.237-266
Hauptverfasser:	Sorek, Rotem, Lawrence, C Martin, Wiedenheft, Blake
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - genetics Antigens Archaea Archaea - genetics Archaea - immunology Bacteria Bacteria - genetics Bacteria - immunology Biochemistry Eukaryotes Immune response Immune system Inverted Repeat Sequences - genetics Inverted Repeat Sequences - immunology Microorganisms Nucleic acids Parasites Prokaryotes Ribonucleic acid RNA RNA, Archaeal - genetics RNA, Archaeal - immunology RNA, Bacterial - genetics RNA, Bacterial - immunology Signal Transduction - genetics Signal Transduction - immunology
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