Spontaneous assembly of DNA–amorphous calcium phosphate nanocomposite spheres for surface-mediated gene transfer

Spontaneous assembly of DNA–amorphous calcium phosphate nanocomposite spheres for surface-mediated gene transfer

Submicrospheres composed of amorphous calcium phosphate (ACP) and DNA spontaneously assembled on a substrate viahomogeneous calcium phosphate (CaP) nucleation followed by deposition in a highly supersaturated labile CaP solution. The nanocomposite layer of sphere assembly showed higher gene transfer...

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Veröffentlicht in:CrystEngComm 2013-01, Vol.15 (25), p.4994-4997
Hauptverfasser: Oyane, Ayako, Araki, Hiroko, Sogo, Yu, Ito, Atsuo, Tsurushima, Hideo
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Araki, Hiroko
Sogo, Yu
Ito, Atsuo
Tsurushima, Hideo
description Submicrospheres composed of amorphous calcium phosphate (ACP) and DNA spontaneously assembled on a substrate viahomogeneous calcium phosphate (CaP) nucleation followed by deposition in a highly supersaturated labile CaP solution. The nanocomposite layer of sphere assembly showed higher gene transfer efficiency than a continuous film nanocomposite layer previously fabricated viaheterogeneous nucleation in a metastable supersaturated solution.
doi_str_mv 10.1039/c3ce40264a
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title Spontaneous assembly of DNA–amorphous calcium phosphate nanocomposite spheres for surface-mediated gene transfer
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