Correlation between super(99m)Tc-HYNIC-octreotide SPECT/CT somatostatin receptor scintigraphy and pathological grading of meningioma

Correlation between super(99m)Tc-HYNIC-octreotide SPECT/CT somatostatin receptor scintigraphy and pathological grading of meningioma

The aim of this study was to explore the association of super(99m)Tc-HYNIC-octreotide SPECT/CT somatostatin receptor scintigraphy (SRS) with the pathological grading and expression of somatostatin receptor 2 (SSTR2) for meningioma, and to define possible roles of SRS in the pathological grading of m...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of neuro-oncology 2013-07, Vol.113 (3), p.519-526
Hauptverfasser: Wang, Shengjun, Yang, Weidong, Deng, Jinglan, Zhang, Jianning, Ma, Fucheng, Wang, Jing
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 526
container_issue 3
container_start_page 519
container_title Journal of neuro-oncology
container_volume 113
creator Wang, Shengjun
Yang, Weidong
Deng, Jinglan
Zhang, Jianning
Ma, Fucheng
Wang, Jing
description The aim of this study was to explore the association of super(99m)Tc-HYNIC-octreotide SPECT/CT somatostatin receptor scintigraphy (SRS) with the pathological grading and expression of somatostatin receptor 2 (SSTR2) for meningioma, and to define possible roles of SRS in the pathological grading of meningioma. Thirty patients with meningiomas diagnosed by MRI and treated with super(99m)Tc-HYNIC-octreotide SPECT/CT SRS. Meningioma tissues were obtained from analyzing pathological grading and measuring the expression of SSTR2 with immunohistochemical staining. The meningioma side (T) to the contralateral side (NT) ratios (T/TN) of radioactive counts were calculated to investigate their association with the pathological grading of meningioma and the expression of SSTR2. All 30 cases showed high meningioma radioactivity accumulation using SRS with a sensitivity of 100 %, while CT scans only detected 25 cases with a sensitivity of 83 %. Twenty cases with grade I meningioma had a T/NT ratio of 3.80 plus or minus 1.67, which was significantly lower than the other 10 cases (9.57 plus or minus 3.78) with a grade II meningioma (P < 0.01). All meningiomas expressed SSTR2 as detected by immunohistochemical staining, and the T/NT ratio was positively associated with the pathological grading of meningioma and the expression of SSTR2 (with r of 0.784 and 0.805, respectively). super(99m)Tc-HYNIC-octreotide SPECT/CT SRS is a sensitive technique for detecting meningioma, and the T/NT ratio of the SRS data closely correlates with the pathological grade of meningioma and the expression of SSTR2.
doi_str_mv 10.1007/s11060-013-1146-y
format Article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_1399915567</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1399915567</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_13999155673</originalsourceid><addsrcrecordid>eNqVjL1OwzAUhS0EEuHnAdg8lsHUV05ieY6KyoKQyABTZZzb1MjxDbYr1J0HJwMvwHSOPp3vMHYH8gGk1OsMIFspJCgBULfidMYqaLQSWml1zioJrRaNqd8u2VXOn1LKWiuo2E9HKWGwxVPkH1i-ESPPxxnTypjpvndi-_781AlyJSEVPyB_fdl0_brreabJFsplkSNP6HAulHh2PhY_JjsfTtzGgc-2HCjQ6J0NfOGDjyOnPZ8wLs0vJzfsYm9Dxtu_vGarx03fbcWc6OuIuewmnx2GYCPSMe9AGWOgaVqt_jH9BVHWXS4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1399915567</pqid></control><display><type>article</type><title>Correlation between super(99m)Tc-HYNIC-octreotide SPECT/CT somatostatin receptor scintigraphy and pathological grading of meningioma</title><source>Springer Nature - Complete Springer Journals</source><creator>Wang, Shengjun ; Yang, Weidong ; Deng, Jinglan ; Zhang, Jianning ; Ma, Fucheng ; Wang, Jing</creator><creatorcontrib>Wang, Shengjun ; Yang, Weidong ; Deng, Jinglan ; Zhang, Jianning ; Ma, Fucheng ; Wang, Jing</creatorcontrib><description>The aim of this study was to explore the association of super(99m)Tc-HYNIC-octreotide SPECT/CT somatostatin receptor scintigraphy (SRS) with the pathological grading and expression of somatostatin receptor 2 (SSTR2) for meningioma, and to define possible roles of SRS in the pathological grading of meningioma. Thirty patients with meningiomas diagnosed by MRI and treated with super(99m)Tc-HYNIC-octreotide SPECT/CT SRS. Meningioma tissues were obtained from analyzing pathological grading and measuring the expression of SSTR2 with immunohistochemical staining. The meningioma side (T) to the contralateral side (NT) ratios (T/TN) of radioactive counts were calculated to investigate their association with the pathological grading of meningioma and the expression of SSTR2. All 30 cases showed high meningioma radioactivity accumulation using SRS with a sensitivity of 100 %, while CT scans only detected 25 cases with a sensitivity of 83 %. Twenty cases with grade I meningioma had a T/NT ratio of 3.80 plus or minus 1.67, which was significantly lower than the other 10 cases (9.57 plus or minus 3.78) with a grade II meningioma (P &lt; 0.01). All meningiomas expressed SSTR2 as detected by immunohistochemical staining, and the T/NT ratio was positively associated with the pathological grading of meningioma and the expression of SSTR2 (with r of 0.784 and 0.805, respectively). super(99m)Tc-HYNIC-octreotide SPECT/CT SRS is a sensitive technique for detecting meningioma, and the T/NT ratio of the SRS data closely correlates with the pathological grade of meningioma and the expression of SSTR2.</description><identifier>ISSN: 0167-594X</identifier><identifier>EISSN: 1573-7373</identifier><identifier>DOI: 10.1007/s11060-013-1146-y</identifier><language>eng</language><ispartof>Journal of neuro-oncology, 2013-07, Vol.113 (3), p.519-526</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Wang, Shengjun</creatorcontrib><creatorcontrib>Yang, Weidong</creatorcontrib><creatorcontrib>Deng, Jinglan</creatorcontrib><creatorcontrib>Zhang, Jianning</creatorcontrib><creatorcontrib>Ma, Fucheng</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><title>Correlation between super(99m)Tc-HYNIC-octreotide SPECT/CT somatostatin receptor scintigraphy and pathological grading of meningioma</title><title>Journal of neuro-oncology</title><description>The aim of this study was to explore the association of super(99m)Tc-HYNIC-octreotide SPECT/CT somatostatin receptor scintigraphy (SRS) with the pathological grading and expression of somatostatin receptor 2 (SSTR2) for meningioma, and to define possible roles of SRS in the pathological grading of meningioma. Thirty patients with meningiomas diagnosed by MRI and treated with super(99m)Tc-HYNIC-octreotide SPECT/CT SRS. Meningioma tissues were obtained from analyzing pathological grading and measuring the expression of SSTR2 with immunohistochemical staining. The meningioma side (T) to the contralateral side (NT) ratios (T/TN) of radioactive counts were calculated to investigate their association with the pathological grading of meningioma and the expression of SSTR2. All 30 cases showed high meningioma radioactivity accumulation using SRS with a sensitivity of 100 %, while CT scans only detected 25 cases with a sensitivity of 83 %. Twenty cases with grade I meningioma had a T/NT ratio of 3.80 plus or minus 1.67, which was significantly lower than the other 10 cases (9.57 plus or minus 3.78) with a grade II meningioma (P &lt; 0.01). All meningiomas expressed SSTR2 as detected by immunohistochemical staining, and the T/NT ratio was positively associated with the pathological grading of meningioma and the expression of SSTR2 (with r of 0.784 and 0.805, respectively). super(99m)Tc-HYNIC-octreotide SPECT/CT SRS is a sensitive technique for detecting meningioma, and the T/NT ratio of the SRS data closely correlates with the pathological grade of meningioma and the expression of SSTR2.</description><issn>0167-594X</issn><issn>1573-7373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqVjL1OwzAUhS0EEuHnAdg8lsHUV05ieY6KyoKQyABTZZzb1MjxDbYr1J0HJwMvwHSOPp3vMHYH8gGk1OsMIFspJCgBULfidMYqaLQSWml1zioJrRaNqd8u2VXOn1LKWiuo2E9HKWGwxVPkH1i-ESPPxxnTypjpvndi-_781AlyJSEVPyB_fdl0_brreabJFsplkSNP6HAulHh2PhY_JjsfTtzGgc-2HCjQ6J0NfOGDjyOnPZ8wLs0vJzfsYm9Dxtu_vGarx03fbcWc6OuIuewmnx2GYCPSMe9AGWOgaVqt_jH9BVHWXS4</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Wang, Shengjun</creator><creator>Yang, Weidong</creator><creator>Deng, Jinglan</creator><creator>Zhang, Jianning</creator><creator>Ma, Fucheng</creator><creator>Wang, Jing</creator><scope>7TK</scope></search><sort><creationdate>20130701</creationdate><title>Correlation between super(99m)Tc-HYNIC-octreotide SPECT/CT somatostatin receptor scintigraphy and pathological grading of meningioma</title><author>Wang, Shengjun ; Yang, Weidong ; Deng, Jinglan ; Zhang, Jianning ; Ma, Fucheng ; Wang, Jing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_13999155673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Shengjun</creatorcontrib><creatorcontrib>Yang, Weidong</creatorcontrib><creatorcontrib>Deng, Jinglan</creatorcontrib><creatorcontrib>Zhang, Jianning</creatorcontrib><creatorcontrib>Ma, Fucheng</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><collection>Neurosciences Abstracts</collection><jtitle>Journal of neuro-oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Shengjun</au><au>Yang, Weidong</au><au>Deng, Jinglan</au><au>Zhang, Jianning</au><au>Ma, Fucheng</au><au>Wang, Jing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between super(99m)Tc-HYNIC-octreotide SPECT/CT somatostatin receptor scintigraphy and pathological grading of meningioma</atitle><jtitle>Journal of neuro-oncology</jtitle><date>2013-07-01</date><risdate>2013</risdate><volume>113</volume><issue>3</issue><spage>519</spage><epage>526</epage><pages>519-526</pages><issn>0167-594X</issn><eissn>1573-7373</eissn><abstract>The aim of this study was to explore the association of super(99m)Tc-HYNIC-octreotide SPECT/CT somatostatin receptor scintigraphy (SRS) with the pathological grading and expression of somatostatin receptor 2 (SSTR2) for meningioma, and to define possible roles of SRS in the pathological grading of meningioma. Thirty patients with meningiomas diagnosed by MRI and treated with super(99m)Tc-HYNIC-octreotide SPECT/CT SRS. Meningioma tissues were obtained from analyzing pathological grading and measuring the expression of SSTR2 with immunohistochemical staining. The meningioma side (T) to the contralateral side (NT) ratios (T/TN) of radioactive counts were calculated to investigate their association with the pathological grading of meningioma and the expression of SSTR2. All 30 cases showed high meningioma radioactivity accumulation using SRS with a sensitivity of 100 %, while CT scans only detected 25 cases with a sensitivity of 83 %. Twenty cases with grade I meningioma had a T/NT ratio of 3.80 plus or minus 1.67, which was significantly lower than the other 10 cases (9.57 plus or minus 3.78) with a grade II meningioma (P &lt; 0.01). All meningiomas expressed SSTR2 as detected by immunohistochemical staining, and the T/NT ratio was positively associated with the pathological grading of meningioma and the expression of SSTR2 (with r of 0.784 and 0.805, respectively). super(99m)Tc-HYNIC-octreotide SPECT/CT SRS is a sensitive technique for detecting meningioma, and the T/NT ratio of the SRS data closely correlates with the pathological grade of meningioma and the expression of SSTR2.</abstract><doi>10.1007/s11060-013-1146-y</doi></addata></record>
fulltext fulltext
identifier ISSN: 0167-594X
ispartof Journal of neuro-oncology, 2013-07, Vol.113 (3), p.519-526
issn 0167-594X
1573-7373
language eng
recordid cdi_proquest_miscellaneous_1399915567
source Springer Nature - Complete Springer Journals
title Correlation between super(99m)Tc-HYNIC-octreotide SPECT/CT somatostatin receptor scintigraphy and pathological grading of meningioma
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T16%3A58%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlation%20between%20super(99m)Tc-HYNIC-octreotide%20SPECT/CT%20somatostatin%20receptor%20scintigraphy%20and%20pathological%20grading%20of%20meningioma&rft.jtitle=Journal%20of%20neuro-oncology&rft.au=Wang,%20Shengjun&rft.date=2013-07-01&rft.volume=113&rft.issue=3&rft.spage=519&rft.epage=526&rft.pages=519-526&rft.issn=0167-594X&rft.eissn=1573-7373&rft_id=info:doi/10.1007/s11060-013-1146-y&rft_dat=%3Cproquest%3E1399915567%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1399915567&rft_id=info:pmid/&rfr_iscdi=true