HLA-DRB1 Genotypes and the Risk of Developing Anti Citrullinated Protein Antibody (ACPA) Positive Rheumatoid Arthritis. e64108
Objective To provide a table indicating the risk for developing anti citrullinated protein antibody (ACPA) positive rheumatoid arthritis (RA) according to one's HLA-DRB1 genotype. Methods We HLA-DRB1 genotyped 857 patients with ACPA positive RA and 2178 controls from South Eastern and Eastern F...
Gespeichert in:
| Veröffentlicht in: | PloS one 2013-05, Vol.8 (5) |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 5 |
| container_start_page | |
| container_title | PloS one |
| container_volume | 8 |
| creator | Balandraud, Nathalie Picard, Christophe Reviron, Denis Landais, Cyril Toussirot, Eric Lambert, Nathalie Telle, Emmanuel Charpin, Caroline Wendling, Daniel Pardoux, Etienne |
| description | Objective To provide a table indicating the risk for developing anti citrullinated protein antibody (ACPA) positive rheumatoid arthritis (RA) according to one's HLA-DRB1 genotype. Methods We HLA-DRB1 genotyped 857 patients with ACPA positive RA and 2178 controls from South Eastern and Eastern France and calculated Odds Ratios (OR) for developing RA for 106 of 132 possible genotypes accounting for 97% of subjects. Results HLA-DRB1 genotypic ORs for developing ACPA positive RA range from 28 to 0.19. HLA-DRB1 genotypes with HLA-DRB1*04SE (HLA-DRB1*0404, HLA-DRB1*0405, HLA-DRB1*0408), HLA-DRB1*04:01, HLA-DRB1*01 are usually associated with high risk for developing RA. The second HLA-DRB1 allele in genotype somewhat modulates shared epitope associated risk. We did not identify any absolutely protective allele. Neither the Reviron, nor the du Montcel models accurately explains our data which are compatible with the shared epitope hypothesis and suggest a dosage effect among shared epitope positive HLA-DRB1 alleles, double dose genotypes carrying higher ORs than single dose genotypes. Conclusion HLA-DRB1 genotypic risk for developing ACPA positive RA is influenced by both HLA-DRB1 alleles in genotype. We provide an HLA-DRB1 genotypic risk table for ACPA positive RA. |
| doi_str_mv | 10.1371/journal.pone.0064108 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_1399914780</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1399914780</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_13999147803</originalsourceid><addsrcrecordid>eNqVjrFOwzAURS0kJAr0DxjeWIYEuy5pMoYU6MAQVd0rQ16Ji-sX_OxKXfh2qoofYLrSPVdHV4g7JXOl5-phRyl44_KBPOZSFjMlywsxUpWeZsVU6itxzbyT8lGXRTESP8u3OlusnhS8oqd4HJDB-A5ij7Cy_AW0hQUe0NFg_SfUPlpobAzJOetNxA7aQBGtP6N36o4wqZu2voeW2EZ7OGl6THsTyXZQh9iHU8s54PnZrbjcGsc4_ssbMXl5XjfLbAj0nZDjZm_5A50zHinxRumqqtRsXkr9j-kv3phYqw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1399914780</pqid></control><display><type>article</type><title>HLA-DRB1 Genotypes and the Risk of Developing Anti Citrullinated Protein Antibody (ACPA) Positive Rheumatoid Arthritis. e64108</title><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Balandraud, Nathalie ; Picard, Christophe ; Reviron, Denis ; Landais, Cyril ; Toussirot, Eric ; Lambert, Nathalie ; Telle, Emmanuel ; Charpin, Caroline ; Wendling, Daniel ; Pardoux, Etienne</creator><creatorcontrib>Balandraud, Nathalie ; Picard, Christophe ; Reviron, Denis ; Landais, Cyril ; Toussirot, Eric ; Lambert, Nathalie ; Telle, Emmanuel ; Charpin, Caroline ; Wendling, Daniel ; Pardoux, Etienne</creatorcontrib><description>Objective To provide a table indicating the risk for developing anti citrullinated protein antibody (ACPA) positive rheumatoid arthritis (RA) according to one's HLA-DRB1 genotype. Methods We HLA-DRB1 genotyped 857 patients with ACPA positive RA and 2178 controls from South Eastern and Eastern France and calculated Odds Ratios (OR) for developing RA for 106 of 132 possible genotypes accounting for 97% of subjects. Results HLA-DRB1 genotypic ORs for developing ACPA positive RA range from 28 to 0.19. HLA-DRB1 genotypes with HLA-DRB1*04SE (HLA-DRB1*0404, HLA-DRB1*0405, HLA-DRB1*0408), HLA-DRB1*04:01, HLA-DRB1*01 are usually associated with high risk for developing RA. The second HLA-DRB1 allele in genotype somewhat modulates shared epitope associated risk. We did not identify any absolutely protective allele. Neither the Reviron, nor the du Montcel models accurately explains our data which are compatible with the shared epitope hypothesis and suggest a dosage effect among shared epitope positive HLA-DRB1 alleles, double dose genotypes carrying higher ORs than single dose genotypes. Conclusion HLA-DRB1 genotypic risk for developing ACPA positive RA is influenced by both HLA-DRB1 alleles in genotype. We provide an HLA-DRB1 genotypic risk table for ACPA positive RA.</description><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0064108</identifier><language>eng</language><subject>Antibodies</subject><ispartof>PloS one, 2013-05, Vol.8 (5)</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27923,27924</link.rule.ids></links><search><creatorcontrib>Balandraud, Nathalie</creatorcontrib><creatorcontrib>Picard, Christophe</creatorcontrib><creatorcontrib>Reviron, Denis</creatorcontrib><creatorcontrib>Landais, Cyril</creatorcontrib><creatorcontrib>Toussirot, Eric</creatorcontrib><creatorcontrib>Lambert, Nathalie</creatorcontrib><creatorcontrib>Telle, Emmanuel</creatorcontrib><creatorcontrib>Charpin, Caroline</creatorcontrib><creatorcontrib>Wendling, Daniel</creatorcontrib><creatorcontrib>Pardoux, Etienne</creatorcontrib><title>HLA-DRB1 Genotypes and the Risk of Developing Anti Citrullinated Protein Antibody (ACPA) Positive Rheumatoid Arthritis. e64108</title><title>PloS one</title><description>Objective To provide a table indicating the risk for developing anti citrullinated protein antibody (ACPA) positive rheumatoid arthritis (RA) according to one's HLA-DRB1 genotype. Methods We HLA-DRB1 genotyped 857 patients with ACPA positive RA and 2178 controls from South Eastern and Eastern France and calculated Odds Ratios (OR) for developing RA for 106 of 132 possible genotypes accounting for 97% of subjects. Results HLA-DRB1 genotypic ORs for developing ACPA positive RA range from 28 to 0.19. HLA-DRB1 genotypes with HLA-DRB1*04SE (HLA-DRB1*0404, HLA-DRB1*0405, HLA-DRB1*0408), HLA-DRB1*04:01, HLA-DRB1*01 are usually associated with high risk for developing RA. The second HLA-DRB1 allele in genotype somewhat modulates shared epitope associated risk. We did not identify any absolutely protective allele. Neither the Reviron, nor the du Montcel models accurately explains our data which are compatible with the shared epitope hypothesis and suggest a dosage effect among shared epitope positive HLA-DRB1 alleles, double dose genotypes carrying higher ORs than single dose genotypes. Conclusion HLA-DRB1 genotypic risk for developing ACPA positive RA is influenced by both HLA-DRB1 alleles in genotype. We provide an HLA-DRB1 genotypic risk table for ACPA positive RA.</description><subject>Antibodies</subject><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqVjrFOwzAURS0kJAr0DxjeWIYEuy5pMoYU6MAQVd0rQ16Ji-sX_OxKXfh2qoofYLrSPVdHV4g7JXOl5-phRyl44_KBPOZSFjMlywsxUpWeZsVU6itxzbyT8lGXRTESP8u3OlusnhS8oqd4HJDB-A5ij7Cy_AW0hQUe0NFg_SfUPlpobAzJOetNxA7aQBGtP6N36o4wqZu2voeW2EZ7OGl6THsTyXZQh9iHU8s54PnZrbjcGsc4_ssbMXl5XjfLbAj0nZDjZm_5A50zHinxRumqqtRsXkr9j-kv3phYqw</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Balandraud, Nathalie</creator><creator>Picard, Christophe</creator><creator>Reviron, Denis</creator><creator>Landais, Cyril</creator><creator>Toussirot, Eric</creator><creator>Lambert, Nathalie</creator><creator>Telle, Emmanuel</creator><creator>Charpin, Caroline</creator><creator>Wendling, Daniel</creator><creator>Pardoux, Etienne</creator><scope>7ST</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>SOI</scope></search><sort><creationdate>20130501</creationdate><title>HLA-DRB1 Genotypes and the Risk of Developing Anti Citrullinated Protein Antibody (ACPA) Positive Rheumatoid Arthritis. e64108</title><author>Balandraud, Nathalie ; Picard, Christophe ; Reviron, Denis ; Landais, Cyril ; Toussirot, Eric ; Lambert, Nathalie ; Telle, Emmanuel ; Charpin, Caroline ; Wendling, Daniel ; Pardoux, Etienne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_13999147803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Antibodies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balandraud, Nathalie</creatorcontrib><creatorcontrib>Picard, Christophe</creatorcontrib><creatorcontrib>Reviron, Denis</creatorcontrib><creatorcontrib>Landais, Cyril</creatorcontrib><creatorcontrib>Toussirot, Eric</creatorcontrib><creatorcontrib>Lambert, Nathalie</creatorcontrib><creatorcontrib>Telle, Emmanuel</creatorcontrib><creatorcontrib>Charpin, Caroline</creatorcontrib><creatorcontrib>Wendling, Daniel</creatorcontrib><creatorcontrib>Pardoux, Etienne</creatorcontrib><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Environment Abstracts</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balandraud, Nathalie</au><au>Picard, Christophe</au><au>Reviron, Denis</au><au>Landais, Cyril</au><au>Toussirot, Eric</au><au>Lambert, Nathalie</au><au>Telle, Emmanuel</au><au>Charpin, Caroline</au><au>Wendling, Daniel</au><au>Pardoux, Etienne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA-DRB1 Genotypes and the Risk of Developing Anti Citrullinated Protein Antibody (ACPA) Positive Rheumatoid Arthritis. e64108</atitle><jtitle>PloS one</jtitle><date>2013-05-01</date><risdate>2013</risdate><volume>8</volume><issue>5</issue><eissn>1932-6203</eissn><abstract>Objective To provide a table indicating the risk for developing anti citrullinated protein antibody (ACPA) positive rheumatoid arthritis (RA) according to one's HLA-DRB1 genotype. Methods We HLA-DRB1 genotyped 857 patients with ACPA positive RA and 2178 controls from South Eastern and Eastern France and calculated Odds Ratios (OR) for developing RA for 106 of 132 possible genotypes accounting for 97% of subjects. Results HLA-DRB1 genotypic ORs for developing ACPA positive RA range from 28 to 0.19. HLA-DRB1 genotypes with HLA-DRB1*04SE (HLA-DRB1*0404, HLA-DRB1*0405, HLA-DRB1*0408), HLA-DRB1*04:01, HLA-DRB1*01 are usually associated with high risk for developing RA. The second HLA-DRB1 allele in genotype somewhat modulates shared epitope associated risk. We did not identify any absolutely protective allele. Neither the Reviron, nor the du Montcel models accurately explains our data which are compatible with the shared epitope hypothesis and suggest a dosage effect among shared epitope positive HLA-DRB1 alleles, double dose genotypes carrying higher ORs than single dose genotypes. Conclusion HLA-DRB1 genotypic risk for developing ACPA positive RA is influenced by both HLA-DRB1 alleles in genotype. We provide an HLA-DRB1 genotypic risk table for ACPA positive RA.</abstract><doi>10.1371/journal.pone.0064108</doi></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1932-6203 |
| ispartof | PloS one, 2013-05, Vol.8 (5) |
| issn | 1932-6203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1399914780 |
| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Antibodies |
| title | HLA-DRB1 Genotypes and the Risk of Developing Anti Citrullinated Protein Antibody (ACPA) Positive Rheumatoid Arthritis. e64108 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T00%3A56%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HLA-DRB1%20Genotypes%20and%20the%20Risk%20of%20Developing%20Anti%20Citrullinated%20Protein%20Antibody%20(ACPA)%20Positive%20Rheumatoid%20Arthritis.%20e64108&rft.jtitle=PloS%20one&rft.au=Balandraud,%20Nathalie&rft.date=2013-05-01&rft.volume=8&rft.issue=5&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0064108&rft_dat=%3Cproquest%3E1399914780%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1399914780&rft_id=info:pmid/&rfr_iscdi=true |