ANTIMICROBIAL ACTIVITY OF 2, 2-BIPYRIDINEDICHLOROPLATINUM (II), C sub( 10)H sub( 8)CL sub( 2)N sub( 2)Pt

Antimicrobial activity of compound (2) was investigated against pathogenic microorganisms: Staphylococcus aureus (Gram (+), Escherichia coli (Gram (-) and fungal strain, Candida albicans using the Well Diffusion and the Poison plate methods. Compound (2) was shown to inhibit pathogenic growth, and judging from the area of the zone of inhibition, the susceptibility of the microorganism against compound (2) follows the sequence: Staphylococcus aureus > Candida albicans > Escherichia coli. The area of zone of inhibition ranging from (4.64 mm super( 2) to 6.47 mm super( 2)) and (4.64mm super( 2) to 5.72 mm super( 2)) for the Well Diffusion and Poison plates respectively. Both methods indicate that the area of the zone of inhibition for compound (2) is more potent than reference antibiotics: Nystatin and Ampicillin.