Prevention of Femoral Head Deformity after Ischemic Necrosis Using Ibandronate Acid and Growth Factor in Imature Pigs

The objective of this study is to determine if a highly potent antiabsorptive agent, ibandronate, would inhibit bone resorption during necrotic femoral head repair to avoid subsequent flattening and deformity, to determine if the use of platelet-rich plasma stimulates bone repair and neovascularizat...

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Veröffentlicht in:Surgical science 2012-04, Vol.3 (4), p.194-194
Hauptverfasser: Russo, Bibiana Dello, Baroni, Eduardo Luis, Saravia, Nicolas, Amelong, Valeria, Lubiniecky, Fabiana, Asprea, Marcelo, Williams, Gustavo, Rodriguez, Susana
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Sprache:eng
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Zusammenfassung:The objective of this study is to determine if a highly potent antiabsorptive agent, ibandronate, would inhibit bone resorption during necrotic femoral head repair to avoid subsequent flattening and deformity, to determine if the use of platelet-rich plasma stimulates bone repair and neovascularization of the damaged femoral head, and to evaluate if the combination of both therapies can preserve the femoral head while stimulating new bone formation in an animal model of ischemic necrosis. Ischemic necrosis of the femoral head was induced by surgical ligature of the circumflex vessels in 10 Landrace pigs. The animals were divided into four different groups and were administered ibandronate acid, platelet-rich plasma, or both. The contralateral, untreated femoral heads with surgical ligature of the circumflex vessels served as the control group. The femur length was measured on radiographs and compared among the groups. Radiographic and histological studies showed that a combination of both therapies (platelet-rich plasma and ibandronate acid) preserved the trabecular architecture and prevented femoral head deformity in the early phase of ischemic necrosis repair in immature pigs, coinciding with reports by other authors.
ISSN:2157-9407
2157-9415