Screening of bioactive compounds in Radix Salviae Miltiorrhizae with liposomes and cell membranes using HPLC

A new method employing HPLC, LC–MS, liposomes and cell membranes for the screening of bioactive compounds in traditional Chinese medicines (TCMs) has been proposed. We hypothesized that exposure of the TCM extracts to liposome membranes or cell membranes should decrease the concentration of membrane...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2012-11, Vol.70, p.194-201
Hauptverfasser:	Chen, Xiaoping, Deng, Yachen, Xue, Ying, Liang, Jianying
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Animals bioactive properties Biological and medical sciences Biological Assay - methods Biological Assay - standards Calibration Cardiac myocyte membrane cardiomyocytes Cell Membrane - metabolism Cell Membrane Permeability cell membranes Centrifugation Chromatography, High Pressure Liquid - standards Drugs, Chinese Herbal - analysis Drugs, Chinese Herbal - metabolism Erythrocyte membrane Erythrocyte Membrane - metabolism erythrocytes Fundamental and applied biological sciences. Psychology General pharmacology high performance liquid chromatography HPLC LC–MS Liposome Liposomes Mass Spectrometry Medical sciences Myocytes, Cardiac - metabolism Oriental traditional medicine permeability Pharmacology. Drug treatments Plants, Medicinal Radix Salviae Miltiorrhizae Rats Reproducibility of Results Salvia miltiorrhiza - chemistry screening vanillic acid
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