Hypotensive and heart rate-lowering effects in rats receiving milk fermented by specific Lactococcus lactis strains
Previous studies have demonstrated that milk fermented by specific Lactococcus lactis strains significantly inhibits the activity of angiotensin I-converting enzyme (ACE). However, the relationship between the ACE inhibitor and its in vivo action has revealed discrepancies. Therefore, the aim of the...
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| Veröffentlicht in: | British journal of nutrition 2013-03, Vol.109 (5), p.827-833 |
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| container_title | British journal of nutrition |
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| creator | Rodríguez-Figueroa, J. C. González-Córdova, A. F. Astiazaran-García, H. Vallejo-Cordoba, B. |
| description | Previous studies have demonstrated that milk fermented by specific Lactococcus lactis strains significantly inhibits the activity of angiotensin I-converting enzyme (ACE). However, the relationship between the ACE inhibitor and its in vivo action has revealed discrepancies. Therefore, the aim of the present study was to investigate the antihypertensive and heart rate (HR)-lowering effect of milk fermented by specific L. lactis in a murine model. Spontaneously hypertensive male rats (271 (SD14) g) were randomised into four treatment groups that were orally administered with milk fermented by L. lactis NRRL B-50 571 or L. lactis NRRL B-50 572 at 35 or 50 mg protein/kg body weight (BW), respectively. Further, two more groups were fed with different solutions as controls: a saline solution as the negative control and Captopril™ (40 mg/kg BW), a proven ACE inhibitor, as the positive control. Blood pressure and HR were monitored by the tail-cuff method before the treatments and at 2, 4, 6 and 24 h post-oral administration. The results demonstrated that milk fermented by L. lactis NRRL B-50 571 as well as by L. lactis NRRL B-50 572 presented an important systolic and diastolic blood pressure- and HR-lowering effect. Thus, milk fermented by specific L. lactis strains may present potential benefits in the prevention and treatment of CVD associated with hypertension in humans. |
| doi_str_mv | 10.1017/S0007114512002115 |
| format | Article |
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C. ; González-Córdova, A. F. ; Astiazaran-García, H. ; Vallejo-Cordoba, B.</creator><creatorcontrib>Rodríguez-Figueroa, J. C. ; González-Córdova, A. F. ; Astiazaran-García, H. ; Vallejo-Cordoba, B.</creatorcontrib><description>Previous studies have demonstrated that milk fermented by specific Lactococcus lactis strains significantly inhibits the activity of angiotensin I-converting enzyme (ACE). However, the relationship between the ACE inhibitor and its in vivo action has revealed discrepancies. Therefore, the aim of the present study was to investigate the antihypertensive and heart rate (HR)-lowering effect of milk fermented by specific L. lactis in a murine model. Spontaneously hypertensive male rats (271 (SD14) g) were randomised into four treatment groups that were orally administered with milk fermented by L. lactis NRRL B-50 571 or L. lactis NRRL B-50 572 at 35 or 50 mg protein/kg body weight (BW), respectively. Further, two more groups were fed with different solutions as controls: a saline solution as the negative control and Captopril™ (40 mg/kg BW), a proven ACE inhibitor, as the positive control. Blood pressure and HR were monitored by the tail-cuff method before the treatments and at 2, 4, 6 and 24 h post-oral administration. The results demonstrated that milk fermented by L. lactis NRRL B-50 571 as well as by L. lactis NRRL B-50 572 presented an important systolic and diastolic blood pressure- and HR-lowering effect. Thus, milk fermented by specific L. lactis strains may present potential benefits in the prevention and treatment of CVD associated with hypertension in humans.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114512002115</identifier><identifier>PMID: 23168230</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Animals ; Arterial hypertension. Arterial hypotension ; Bacteria ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure ; Body weight ; Cardiology. Vascular system ; Cardiovascular Diseases - diet therapy ; Cardiovascular Diseases - prevention & control ; Cultured Milk Products ; Diet ; Experimental diseases ; Feeding. Feeding behavior ; Fermentation ; Fundamental and applied biological sciences. Psychology ; Heart Rate ; Hypertension ; Hypertension - diet therapy ; Lactococcus lactis ; Lactococcus lactis - metabolism ; Male ; Medical sciences ; Metabolism and Metabolic Studies ; Milk ; Milk - microbiology ; Rats ; Rats, Inbred SHR ; Rodents ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>British journal of nutrition, 2013-03, Vol.109 (5), p.827-833</ispartof><rights>Copyright © The Authors 2012</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-92b1e47caf0181688ad5ca1f27c7f38300840487e513ded94f7e444eac242c2c3</citedby><cites>FETCH-LOGICAL-c502t-92b1e47caf0181688ad5ca1f27c7f38300840487e513ded94f7e444eac242c2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114512002115/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27104885$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23168230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodríguez-Figueroa, J. C.</creatorcontrib><creatorcontrib>González-Córdova, A. F.</creatorcontrib><creatorcontrib>Astiazaran-García, H.</creatorcontrib><creatorcontrib>Vallejo-Cordoba, B.</creatorcontrib><title>Hypotensive and heart rate-lowering effects in rats receiving milk fermented by specific Lactococcus lactis strains</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Previous studies have demonstrated that milk fermented by specific Lactococcus lactis strains significantly inhibits the activity of angiotensin I-converting enzyme (ACE). However, the relationship between the ACE inhibitor and its in vivo action has revealed discrepancies. Therefore, the aim of the present study was to investigate the antihypertensive and heart rate (HR)-lowering effect of milk fermented by specific L. lactis in a murine model. Spontaneously hypertensive male rats (271 (SD14) g) were randomised into four treatment groups that were orally administered with milk fermented by L. lactis NRRL B-50 571 or L. lactis NRRL B-50 572 at 35 or 50 mg protein/kg body weight (BW), respectively. Further, two more groups were fed with different solutions as controls: a saline solution as the negative control and Captopril™ (40 mg/kg BW), a proven ACE inhibitor, as the positive control. Blood pressure and HR were monitored by the tail-cuff method before the treatments and at 2, 4, 6 and 24 h post-oral administration. The results demonstrated that milk fermented by L. lactis NRRL B-50 571 as well as by L. lactis NRRL B-50 572 presented an important systolic and diastolic blood pressure- and HR-lowering effect. Thus, milk fermented by specific L. lactis strains may present potential benefits in the prevention and treatment of CVD associated with hypertension in humans.</description><subject>Animals</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Bacteria</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure</subject><subject>Body weight</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - diet therapy</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Cultured Milk Products</subject><subject>Diet</subject><subject>Experimental diseases</subject><subject>Feeding. Feeding behavior</subject><subject>Fermentation</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Heart Rate</topic><topic>Hypertension</topic><topic>Hypertension - diet therapy</topic><topic>Lactococcus lactis</topic><topic>Lactococcus lactis - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolism and Metabolic Studies</topic><topic>Milk</topic><topic>Milk - microbiology</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rodents</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodríguez-Figueroa, J. C.</creatorcontrib><creatorcontrib>González-Córdova, A. 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C.</au><au>González-Córdova, A. F.</au><au>Astiazaran-García, H.</au><au>Vallejo-Cordoba, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypotensive and heart rate-lowering effects in rats receiving milk fermented by specific Lactococcus lactis strains</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2013-03-14</date><risdate>2013</risdate><volume>109</volume><issue>5</issue><spage>827</spage><epage>833</epage><pages>827-833</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Previous studies have demonstrated that milk fermented by specific Lactococcus lactis strains significantly inhibits the activity of angiotensin I-converting enzyme (ACE). However, the relationship between the ACE inhibitor and its in vivo action has revealed discrepancies. Therefore, the aim of the present study was to investigate the antihypertensive and heart rate (HR)-lowering effect of milk fermented by specific L. lactis in a murine model. Spontaneously hypertensive male rats (271 (SD14) g) were randomised into four treatment groups that were orally administered with milk fermented by L. lactis NRRL B-50 571 or L. lactis NRRL B-50 572 at 35 or 50 mg protein/kg body weight (BW), respectively. Further, two more groups were fed with different solutions as controls: a saline solution as the negative control and Captopril™ (40 mg/kg BW), a proven ACE inhibitor, as the positive control. Blood pressure and HR were monitored by the tail-cuff method before the treatments and at 2, 4, 6 and 24 h post-oral administration. The results demonstrated that milk fermented by L. lactis NRRL B-50 571 as well as by L. lactis NRRL B-50 572 presented an important systolic and diastolic blood pressure- and HR-lowering effect. Thus, milk fermented by specific L. lactis strains may present potential benefits in the prevention and treatment of CVD associated with hypertension in humans.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>23168230</pmid><doi>10.1017/S0007114512002115</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Arterial hypertension. Arterial hypotension Bacteria Biological and medical sciences Blood and lymphatic vessels Blood Pressure Body weight Cardiology. Vascular system Cardiovascular Diseases - diet therapy Cardiovascular Diseases - prevention & control Cultured Milk Products Diet Experimental diseases Feeding. Feeding behavior Fermentation Fundamental and applied biological sciences. Psychology Heart Rate Hypertension Hypertension - diet therapy Lactococcus lactis Lactococcus lactis - metabolism Male Medical sciences Metabolism and Metabolic Studies Milk Milk - microbiology Rats Rats, Inbred SHR Rodents Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Hypotensive and heart rate-lowering effects in rats receiving milk fermented by specific Lactococcus lactis strains |
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