Controlled Drug Delivery System Based on Ordered Mesoporous Silica Matrices of Captopril as Angiotensin-Converting Enzyme Inhibitor Drug
In the present study, captopril-loaded ordered mesoporous SBA-15 silica matrix were produced, functionalized, and characterized to obtain an efficient formulation of controlled drug delivery system. First, the starting SBA-15 materials are examined to verify that their synthesis has been successful...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 2011-02, Vol.100 (2), p.704-714 |
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| creator | Popovici, R.F. Seftel, E.M. Mihai, G.D. Popovici, E. Voicu, V.A. |
| description | In the present study, captopril-loaded ordered mesoporous SBA-15 silica matrix were produced, functionalized, and characterized to obtain an efficient formulation of controlled drug delivery system. First, the starting SBA-15 materials are examined to verify that their synthesis has been successful considering the structural properties, using XRD, FTIR, and BET methods. Second, the influence of processing parameters of ordered mesoporous matrices for the loading and release of captopril was investigated. The release of captopril was controlled by tailoring the surface properties of the mesoporous silica via functionalization. The loading and release kinetics (in vitro in simulated gastric and intestinal fluids) showed that both of them were affected by the surface properties of the mesoporous silica materials. Such a formulation shows potential as an efficient controlled drug delivery system. |
| doi_str_mv | 10.1002/jps.22308 |
| format | Article |
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First, the starting SBA-15 materials are examined to verify that their synthesis has been successful considering the structural properties, using XRD, FTIR, and BET methods. Second, the influence of processing parameters of ordered mesoporous matrices for the loading and release of captopril was investigated. The release of captopril was controlled by tailoring the surface properties of the mesoporous silica via functionalization. The loading and release kinetics (in vitro in simulated gastric and intestinal fluids) showed that both of them were affected by the surface properties of the mesoporous silica materials. Such a formulation shows potential as an efficient controlled drug delivery system.</description><identifier>ISSN: 0022-3549</identifier><identifier>ISSN: 1520-6017</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.22308</identifier><identifier>PMID: 20740675</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Hoboken: Elsevier Inc</publisher><subject>Angiotensin-Converting Enzyme Inhibitors - administration & dosage ; Biological and medical sciences ; captopril ; Captopril - administration & dosage ; controlled release ; Delayed-Action Preparations - chemistry ; diffusion ; drug design ; drug transport ; FTIR ; General pharmacology ; Medical sciences ; mesoporous materials ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Porosity ; Powder Diffraction ; Silicon Dioxide - chemistry ; Spectroscopy, Fourier Transform Infrared ; surface functionalization ; X-Ray Diffraction ; X-ray powder diffractometry</subject><ispartof>Journal of pharmaceutical sciences, 2011-02, Vol.100 (2), p.704-714</ispartof><rights>2011 Wiley-Liss, Inc. and the American Pharmacists Association</rights><rights>Copyright © 2010 Wiley‐Liss, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5328-893fc7866bf67c86e1a487120ee3357dd2c80f94e142037525d96e534e0cbfeb3</citedby><cites>FETCH-LOGICAL-c5328-893fc7866bf67c86e1a487120ee3357dd2c80f94e142037525d96e534e0cbfeb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.22308$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.22308$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23916912$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20740675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Popovici, R.F.</creatorcontrib><creatorcontrib>Seftel, E.M.</creatorcontrib><creatorcontrib>Mihai, G.D.</creatorcontrib><creatorcontrib>Popovici, E.</creatorcontrib><creatorcontrib>Voicu, V.A.</creatorcontrib><title>Controlled Drug Delivery System Based on Ordered Mesoporous Silica Matrices of Captopril as Angiotensin-Converting Enzyme Inhibitor Drug</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>In the present study, captopril-loaded ordered mesoporous SBA-15 silica matrix were produced, functionalized, and characterized to obtain an efficient formulation of controlled drug delivery system. First, the starting SBA-15 materials are examined to verify that their synthesis has been successful considering the structural properties, using XRD, FTIR, and BET methods. Second, the influence of processing parameters of ordered mesoporous matrices for the loading and release of captopril was investigated. The release of captopril was controlled by tailoring the surface properties of the mesoporous silica via functionalization. The loading and release kinetics (in vitro in simulated gastric and intestinal fluids) showed that both of them were affected by the surface properties of the mesoporous silica materials. Such a formulation shows potential as an efficient controlled drug delivery system.</description><subject>Angiotensin-Converting Enzyme Inhibitors - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>captopril</subject><subject>Captopril - administration & dosage</subject><subject>controlled release</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>diffusion</subject><subject>drug design</subject><subject>drug transport</subject><subject>FTIR</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>mesoporous materials</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Porosity</subject><subject>Powder Diffraction</subject><subject>Silicon Dioxide - chemistry</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>surface functionalization</subject><subject>X-Ray Diffraction</subject><subject>X-ray powder diffractometry</subject><issn>0022-3549</issn><issn>1520-6017</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kd1uEzEQhS0EoiFwwQsgSwgJLrb1z9revSxJKUUNRQqI3lmOdzY47NrB3hTCE_DYuE1aJAQ3tqX5Zs4cH4SeUnJICWFHq3U6ZIyT6h4aUcFIIQlV99Eo11jBRVkfoEcprQghkgjxEB0wokoilRihX5Pghxi6Dho8jZslnkLnriBu8XybBujxa5NyKXh8ERuI-TmDFNYhhk3Cc9c5a_DMDNFZSDi0eGLWQ1hH12GT8LFfujCAT84XWSePHZxf4hP_c9sDPvNf3MINId4IP0YPWtMleLK_x-jTm5OPk7fF-cXp2eT4vLCCs6qoat5aVUm5aKWylQRqykpRRgA4F6ppmK1IW5dAS0a4Ekw0tQTBSyB20cKCj9HL3dx1DN82kAbdu2Sh64yH7ElTXtc1KWXJMvr8L3QVNtHn7TQVVPFKqnyO0asdZWNIKUKrs_3exK2mRF_Ho3M8-iaezD7bT9wsemjuyNs8MvBiD5hkTddG461LfzheU1nT69WOdtx318H2_4r63Yf5rXSx63A51h93HSZ-1VLlj9Kf35_q2eW0LKvJVF9mnu94yGFcOYg6WQfeQuMi2EE3wf3D4G9iL8eO</recordid><startdate>201102</startdate><enddate>201102</enddate><creator>Popovici, R.F.</creator><creator>Seftel, E.M.</creator><creator>Mihai, G.D.</creator><creator>Popovici, E.</creator><creator>Voicu, V.A.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><general>Elsevier Limited</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201102</creationdate><title>Controlled Drug Delivery System Based on Ordered Mesoporous Silica Matrices of Captopril as Angiotensin-Converting Enzyme Inhibitor Drug</title><author>Popovici, R.F. ; Seftel, E.M. ; Mihai, G.D. ; Popovici, E. ; Voicu, V.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5328-893fc7866bf67c86e1a487120ee3357dd2c80f94e142037525d96e534e0cbfeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Angiotensin-Converting Enzyme Inhibitors - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>captopril</topic><topic>Captopril - administration & dosage</topic><topic>controlled release</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>diffusion</topic><topic>drug design</topic><topic>drug transport</topic><topic>FTIR</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>mesoporous materials</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. 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| ispartof | Journal of pharmaceutical sciences, 2011-02, Vol.100 (2), p.704-714 |
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| subjects | Angiotensin-Converting Enzyme Inhibitors - administration & dosage Biological and medical sciences captopril Captopril - administration & dosage controlled release Delayed-Action Preparations - chemistry diffusion drug design drug transport FTIR General pharmacology Medical sciences mesoporous materials Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Porosity Powder Diffraction Silicon Dioxide - chemistry Spectroscopy, Fourier Transform Infrared surface functionalization X-Ray Diffraction X-ray powder diffractometry |
| title | Controlled Drug Delivery System Based on Ordered Mesoporous Silica Matrices of Captopril as Angiotensin-Converting Enzyme Inhibitor Drug |
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