Shear-stress sensitive lenticular vesicles for targeted drug delivery

Atherosclerosis results in the narrowing of arterial blood vessels and this causes significant changes in the endogenous shear stress between healthy and constricted arteries. Nanocontainers that can release drugs locally with such rheological changes can be very useful. Here, we show that vesicles...

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Veröffentlicht in:	Nature nanotechnology 2012-08, Vol.7 (8), p.536-543
Hauptverfasser:	Holme, Margaret N., Fedotenko, Illya A., Abegg, Daniel, Althaus, Jasmin, Babel, Lucille, Favarger, France, Reiter, Renate, Tanasescu, Radu, Zaffalon, Pierre-Léonard, Ziegler, André, Müller, Bert, Saxer, Till, Zumbuehl, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/592/75/593/2100 639/925/352/152 Arteries - drug effects Arteries - pathology Blood vessels Cardiovascular system Cardiovascular System - drug effects Chemistry and Materials Science Drug Delivery Systems Drugs Ethanolamines - chemical synthesis Ethanolamines - chemistry Ethanolamines - pharmacology Humans Hydrogen bonds Lipids Lipids - chemistry Materials Science Morphology Nanostructures - chemistry Nanotechnology Nanotechnology and Microengineering Phosphate esters Phospholipids - chemistry Polymers Rheology Shear stress Stress, Mechanical
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