Shear-stress sensitive lenticular vesicles for targeted drug delivery
Atherosclerosis results in the narrowing of arterial blood vessels and this causes significant changes in the endogenous shear stress between healthy and constricted arteries. Nanocontainers that can release drugs locally with such rheological changes can be very useful. Here, we show that vesicles...
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| Veröffentlicht in: | Nature nanotechnology 2012-08, Vol.7 (8), p.536-543 |
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| creator | Holme, Margaret N. Fedotenko, Illya A. Abegg, Daniel Althaus, Jasmin Babel, Lucille Favarger, France Reiter, Renate Tanasescu, Radu Zaffalon, Pierre-Léonard Ziegler, André Müller, Bert Saxer, Till Zumbuehl, Andreas |
| description | Atherosclerosis results in the narrowing of arterial blood vessels and this causes significant changes in the endogenous shear stress between healthy and constricted arteries. Nanocontainers that can release drugs locally with such rheological changes can be very useful. Here, we show that vesicles made from an artificial 1,3-diaminophospholipid are stable under static conditions but release their contents at elevated shear stress. These vesicles have a lenticular morphology, which potentially leads to instabilities along their equator. Using a model cardiovascular system based on polymer tubes and an external pump to represent shear stress in healthy and constricted vessels of the heart, we show that drugs preferentially release from the vesicles in constricted vessels that have high shear stress.
Lentil-shaped phospholipid vesicles are sensitive to shear stress, offering a new class of materials that can deliver drugs in response to rheological changes in the body. |
| doi_str_mv | 10.1038/nnano.2012.84 |
| format | Article |
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Lentil-shaped phospholipid vesicles are sensitive to shear stress, offering a new class of materials that can deliver drugs in response to rheological changes in the body.</description><identifier>ISSN: 1748-3387</identifier><identifier>EISSN: 1748-3395</identifier><identifier>DOI: 10.1038/nnano.2012.84</identifier><identifier>PMID: 22683843</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/443/592/75/593/2100 ; 639/925/352/152 ; Arteries - drug effects ; Arteries - pathology ; Blood vessels ; Cardiovascular system ; Cardiovascular System - drug effects ; Chemistry and Materials Science ; Drug Delivery Systems ; Drugs ; Ethanolamines - chemical synthesis ; Ethanolamines - chemistry ; Ethanolamines - pharmacology ; Humans ; Hydrogen bonds ; Lipids ; Lipids - chemistry ; Materials Science ; Morphology ; Nanostructures - chemistry ; Nanotechnology ; Nanotechnology and Microengineering ; Phosphate esters ; Phospholipids - chemistry ; Polymers ; Rheology ; Shear stress ; Stress, Mechanical</subject><ispartof>Nature nanotechnology, 2012-08, Vol.7 (8), p.536-543</ispartof><rights>Springer Nature Limited 2012</rights><rights>Copyright Nature Publishing Group Aug 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p208t-665142af93d42f27972ef9efd0b488bc7608a7fabeed075f6b2a603e4a68caf33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nnano.2012.84$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nnano.2012.84$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22683843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holme, Margaret N.</creatorcontrib><creatorcontrib>Fedotenko, Illya A.</creatorcontrib><creatorcontrib>Abegg, Daniel</creatorcontrib><creatorcontrib>Althaus, Jasmin</creatorcontrib><creatorcontrib>Babel, Lucille</creatorcontrib><creatorcontrib>Favarger, France</creatorcontrib><creatorcontrib>Reiter, Renate</creatorcontrib><creatorcontrib>Tanasescu, Radu</creatorcontrib><creatorcontrib>Zaffalon, Pierre-Léonard</creatorcontrib><creatorcontrib>Ziegler, André</creatorcontrib><creatorcontrib>Müller, Bert</creatorcontrib><creatorcontrib>Saxer, Till</creatorcontrib><creatorcontrib>Zumbuehl, Andreas</creatorcontrib><title>Shear-stress sensitive lenticular vesicles for targeted drug delivery</title><title>Nature nanotechnology</title><addtitle>Nature Nanotech</addtitle><addtitle>Nat Nanotechnol</addtitle><description>Atherosclerosis results in the narrowing of arterial blood vessels and this causes significant changes in the endogenous shear stress between healthy and constricted arteries. Nanocontainers that can release drugs locally with such rheological changes can be very useful. Here, we show that vesicles made from an artificial 1,3-diaminophospholipid are stable under static conditions but release their contents at elevated shear stress. These vesicles have a lenticular morphology, which potentially leads to instabilities along their equator. Using a model cardiovascular system based on polymer tubes and an external pump to represent shear stress in healthy and constricted vessels of the heart, we show that drugs preferentially release from the vesicles in constricted vessels that have high shear stress.
Lentil-shaped phospholipid vesicles are sensitive to shear stress, offering a new class of materials that can deliver drugs in response to rheological changes in the body.</description><subject>631/443/592/75/593/2100</subject><subject>639/925/352/152</subject><subject>Arteries - drug effects</subject><subject>Arteries - pathology</subject><subject>Blood vessels</subject><subject>Cardiovascular system</subject><subject>Cardiovascular System - drug effects</subject><subject>Chemistry and Materials Science</subject><subject>Drug Delivery Systems</subject><subject>Drugs</subject><subject>Ethanolamines - chemical synthesis</subject><subject>Ethanolamines - chemistry</subject><subject>Ethanolamines - pharmacology</subject><subject>Humans</subject><subject>Hydrogen bonds</subject><subject>Lipids</subject><subject>Lipids - chemistry</subject><subject>Materials Science</subject><subject>Morphology</subject><subject>Nanostructures - chemistry</subject><subject>Nanotechnology</subject><subject>Nanotechnology and Microengineering</subject><subject>Phosphate esters</subject><subject>Phospholipids - chemistry</subject><subject>Polymers</subject><subject>Rheology</subject><subject>Shear stress</subject><subject>Stress, 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Nanocontainers that can release drugs locally with such rheological changes can be very useful. Here, we show that vesicles made from an artificial 1,3-diaminophospholipid are stable under static conditions but release their contents at elevated shear stress. These vesicles have a lenticular morphology, which potentially leads to instabilities along their equator. Using a model cardiovascular system based on polymer tubes and an external pump to represent shear stress in healthy and constricted vessels of the heart, we show that drugs preferentially release from the vesicles in constricted vessels that have high shear stress.
Lentil-shaped phospholipid vesicles are sensitive to shear stress, offering a new class of materials that can deliver drugs in response to rheological changes in the body.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>22683843</pmid><doi>10.1038/nnano.2012.84</doi><tpages>8</tpages></addata></record> |
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| subjects | 631/443/592/75/593/2100 639/925/352/152 Arteries - drug effects Arteries - pathology Blood vessels Cardiovascular system Cardiovascular System - drug effects Chemistry and Materials Science Drug Delivery Systems Drugs Ethanolamines - chemical synthesis Ethanolamines - chemistry Ethanolamines - pharmacology Humans Hydrogen bonds Lipids Lipids - chemistry Materials Science Morphology Nanostructures - chemistry Nanotechnology Nanotechnology and Microengineering Phosphate esters Phospholipids - chemistry Polymers Rheology Shear stress Stress, Mechanical |
| title | Shear-stress sensitive lenticular vesicles for targeted drug delivery |
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