A novel hybrid delivery system: Polymer-oil nanostructured carrier for controlled delivery of highly lipophilic drug all-trans-retinoic acid (ATRA)

Many recently developed drugs encounter delivery issues due to their high lipophilicity and poor aqueous solubility. This study reports the development of a novel hybrid nanocarrier known as polymer-oil nanostructured carrier (PONC), in which highly lipophilic drugs such as all-trans-retinoic acid (...

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Veröffentlicht in:	International journal of pharmaceutics 2012-10, Vol.436 (1-2), p.721-731
Hauptverfasser:	Narvekar, Mayuri, Xue, Hui Yi, Wong, Ho Lun
Format:	Artikel
Sprache:	eng
Schlagworte:	All-trans retinoic acid anticarcinogenic activity antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Cell Line Cell Line, Tumor Cell Survival - drug effects Controlled drug delivery differential scanning calorimetry Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Stability encapsulation Humans Hydrophobic and Hydrophilic Interactions hydrophobicity indomethacin Lactic Acid - administration & dosage Lactic Acid - chemistry Lipophilic drug nanocarriers Nanomedicine nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry oils Oils - administration & dosage Oils - chemistry PLGA Polyglycolic Acid - administration & dosage Polyglycolic Acid - chemistry solubility temperature toxicity Tretinoin - administration & dosage Tretinoin - chemistry
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