Estrogen-regulated synaptogenesis in the hippocampus: Sexual dimorphism in vivo but not in vitro

Hippocampal neurons are capable of synthesizing estradiol de novo. Estradiol synthesis can be suppressed by aromatase inhibitors and by knock-down of steroid acute regulatory protein (StAR), whereas elevated levels of substrates of steroidogenesis enhance estradiol synthesis. In rat hippocampal cult...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2012-08, Vol.131 (1-2), p.24-29
Hauptverfasser:	Fester, Lars, Prange-Kiel, Janine, Zhou, Lepu, Blittersdorf, Breda v., Böhm, Julia, Jarry, Hubertus, Schumacher, Michael, Rune, Gabriele M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aromatase Aromatase - metabolism Aromatase Inhibitors - pharmacology Cells, Cultured Cerebral Cortex - metabolism Dendritic Spines - drug effects Dendritic Spines - physiology Estradiol - biosynthesis Estradiol - physiology Estrus - physiology Female GnRH Hippocampus Hippocampus - drug effects Hippocampus - physiology Hypothalamus - metabolism Letrozole Male Nitriles - pharmacology Rats Receptors, Estrogen - biosynthesis Sex Factors Spine synapses Synapses - drug effects Synapses - physiology Triazoles - pharmacology
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